A5010756701- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Acute Lymphoblastic Leukemia research
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Long-Term Effects of COVID-19
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- T-cell and Retrovirus Studies
- Multiple and Secondary Primary Cancers
- Hormonal and reproductive studies
- Chronic Myeloid Leukemia Treatments
- vaccines and immunoinformatics approaches
University of Copenhagen
2008-2025
Copenhagen University Hospital
2016-2025
Rigshospitalet
2021-2025
Herlev Hospital
2015-2024
Institute of Hematology & Blood Diseases Hospital
2015-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2022
Gentofte Hospital
2017-2021
Aarhus University Hospital
2015
Roskilde Sygehus
2014
Gesundheitsamt
2014
T cells are important for effective viral clearance, elimination of virus-infected and long-term disease protection. To examine the full-spectrum CD8
Patients with multiple myeloma (MM) suffer from a general impaired immunity comprising deficiencies in humoral responses, T-cell responses as well dendritic cell (DC) function. Thus, to achieve control of tumour growth through immune therapy constitutes challenge. Careful evaluation the status patients MM seems crucial prior active therapy. We evaluated proportion both, DC, Treg cells and myeloid-derived suppressor (MDSC) peripheral blood at diagnosis remission monoclonal gammopathy...
In large B-cell lymphoma (LBCL) MYC- and MYC/BCL2 double-hit (DH) translocations have been associated with inferior survival. We hypothesised that the negative prognostic impact of MYC translocation was determined by an immunoglobulin partner gene (IG-MYC), as opposed to a non-immunoglobulin (nonIG-MYC). prospective, unselected cohort 237 LBCL patients BCL2 were identified fluorescent in situ hybridisation (FISH) split probes. IGH/MYC fusion probes and/or kappa/lambda Clinical data collected...
Abstract Human endogenous retroviruses (HERV) form a substantial part of the human genome, but mostly remain transcriptionally silent under strict epigenetic regulation, yet can potentially be reactivated by malignant transformation or therapies. Here, we evaluate potential for T cell recognition HERV elements in myeloid malignancies mapping transcribed genes and generating library 1169 antigenic HERV-derived peptides predicted presentation 4 HLA class I molecules. Using DNA barcode-labeled...
Concurrent BCL2 and MYC translocations, so called double hit (DH), are a rare finding in large B-cell lymphoma (LBCL). Based on data from retrospective series, DH has been correlated with aggressive clinical behaviour poor outcome. We conducted consecutive study of incidence correlation pathologic characteristics, including response to Rituximab-containing chemotherapy survival, an unselected cohort patients LBCL. Translocations involving loci were examined fluorescent situ hybridization...
Treatment with the demethylating agent 5-Azacytidine leads to prolonged survival for patients myelodysplastic syndrome, and demethylation induces upregulation of cancer-testis antigens. Cancer-testis antigens are well-known targets immune recognition in cancer, system may have a role this treatment regimen. We show here that increased T-cell tumor cells. responses against large panel were detected before treatment, these further induced upon initiation treatment. These characteristics point...
Patients with hematological malignancies are prioritized for COVID-19 vaccine due to their high risk severe SARS-CoV-2 infection-related disease and mortality. To understand T cell immunity, its long-term persistence, correlation antibody response, we evaluated the BNT162b2 mRNA vaccine-specific immune response in chronic lymphocytic leukemia (CLL) myeloid dysplastic syndrome (MDS) patients. Longitudinal analysis of CD8 + cells using DNA-barcoded peptide-MHC multimers covering full...
ABSTRACT Despite advances in treatment, approximately 15% of patients with diffuse large B‐cell lymphoma (DLBCL) who achieve complete remission (CR) after first‐line therapy will experience a relapse. However, there is no consensus on the optimal follow‐up strategies for detecting relapse achieving CR. This population‐based study, based Danish Lymphoma Registry (LYFO), identified total 1634 diagnosed DLBCL between 2010 and 2017, including 105 achieved CR following R‐CHOP‐like subsequently...
CD8+ T-cells are essential for controlling and resolving SARS-CoV-2 infection, yet their antigen-specific resolution in relation to disease severity, functional dynamics during acute long-term memory formation remain incompletely understood. Using comprehensive longitudinal profiling of 553 immunogenic antigens across globally prevalent HLAs, we identified T-cell responses that were either critical early viral clearance or associated with severe outcomes. During patients COVID-19 exhibited a...
The role of c-myc in multiple myeloma (MM) is controversial. We conducted a retrospective study 117 patients with MM diagnosed between 2004 and 2010 at Herlev Hospital. Immunohistochemistry (IHC) fluorescent situ hybridization (FISH) were performed on tissue microarrays (TMAs) made from diagnostic bone marrow aspirates. Clinical data obtained the Danish Multiple Myeloma Database (DMMD). Overexpression was found 40% patients. MYC translocation 10% not associated translocation. hypercalcemia...
Summary Watch and wait ( WAW ) is a common approach for asymptomatic, advanced stage follicular lymphoma FL ), but single‐agent rituximab an alternative these patients. In this nationwide study we describe the outcome of patients selected . A cohort 286 out 849 (34%) III ‐ IVA seen between 2000 2011, were managed expectantly included. The 5‐year progression‐free survival PFS was 35% [95% confidence interval CI 29–42]. 10‐year overall OS 65% (95% 54–78), cumulative risk dying from within 10...
With improved survival in patients with lymphoma, long-term toxicity and quality of life (QoL), including sexual health, have become increasingly important.We aimed to (1) determine the prevalence erectile dysfunction (ED) adult male lymphoma survivors; (2) whether testosterone deficiency, comorbidities, or lifestyle factors were associated; (3) evaluate their impact on QoL.A cross-sectional study 172 survivors Hodgkin diffuse large B cell diagnosed adulthood between 2008 2018 was performed....
The introduction of rituximab and generally improved health among elderly patients have increased the survival with diffuse large B-cell lymphoma (DLBCL). International Prognostic Index (IPI) from 1992 is based on pre-rituximab data clinical trials including several subtypes. We applied IPI factors to a population-based rituximab-treated cohort 1990 diagnosed 2000-2010 explored new optimal prognostic age cut-off for DLBCL. Multivariate-analyses (MVA) confirmed value all except presence > 1...
Multicolor flow cytometry is an essential tool for studying the immune system in health and disease, allowing users to extract longitudinal multiparametric data from patient samples. The process complicated by substantial variation performance between each instrument, analytical errors are therefore common. Here, we present approach overcome such limitations applying a systematic workflow pairing colors markers optimized equipment intended run experiments. exemplified design of four...
The immune pathogenesis underlying the diverse clinical course of COVID-19 is poorly understood. Currently, there an unmet need in daily practice for early biomarkers and improved risk stratification tools to help identify monitor patients at severe disease.We performed longitudinal assessment stimulated responses 30 hospitalized with COVID-19. We used TruCulture whole-blood ligand-stimulation assay applying standardized stimuli activate distinct pathways, allowing quantification cytokine...
Abstract Background Several clinical prognostic models for diffuse large B‐cell lymphoma (DLBCL) have been proposed, including the most commonly used International Prognostic Index (IPI), National Comprehensive Cancer Network IPI (NCCN‐IPI), and incorporating beta‐2 microglobulin (β2M). However, role of β2M in DLBCL patients is not fully understood. Methods We identified 6075 with newly diagnosed treated immunochemotherapy registered Danish Lymphoma Registry. Results A total 3232 had data...
Background Double expression of MYC and BCL2 proteins (DE) double-hit MYC+BCL2/BCL6 translocations (DH) were established as important biomarkers in patients with diffuse large B-cell lymphoma (DLBCL) by the 2016 revision World Health Organization classification lymphoid neoplasms. Whether this applies to subgroup young high risk DLBCL is not known. We previously found that a uniform retrospective population-based cohort aged 18–60 years high-risk DLBCL, addition etoposide R-CHOP chemotherapy...