Shawn Levy
A5034381224- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Genomics and Rare Diseases
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Metabolomics and Mass Spectrometry Studies
- Genetics and Neurodevelopmental Disorders
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Genomic variations and chromosomal abnormalities
- Pancreatic function and diabetes
- Molecular Biology Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Mitochondrial Function and Pathology
- Indoor Air Quality and Microbial Exposure
- RNA Research and Splicing
- Genetic Syndromes and Imprinting
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- T-cell and Retrovirus Studies
- Disaster Response and Management
- Air Quality and Health Impacts
Elements Biosciences (United States)
2023-2025
HudsonAlpha Institute for Biotechnology
2015-2024
Discovery Institute
2021
Juno Therapeutics (Germany)
2018
Pfizer (United Kingdom)
2018
Gilead Sciences (Germany)
2018
Medtronic (United States)
2018
Cytokinetics (United States)
2018
St. Jude Children's Research Hospital
2018
Incyte (United States)
2018
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment. We report the results of moderate-scale sequencing study aimed at increasing number genes known to contribute predisposition for ALS. performed whole-exome 2869 ALS patients and 6405 controls. Several were found be associated, TBK1 (the gene encoding TANK-binding kinase 1) was identified as an gene. bind phosphorylate proteins involved in innate immunity autophagy, including optineurin...
Abstract Motivation: Cancer diagnosis is one of the most important emerging clinical applications gene expression microarray technology. We are seeking to develop a computer system for powerful and reliable cancer diagnostic model creation based on data. To keep realistic perspective we focus multicategory diagnosis. equip with optimum combination classifier, selection cross-validation methods, performed systematic comprehensive evaluation several major algorithms classification, multiple...
Microglia are resident immune cells of the CNS that activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry deep RNA sequencing acutely isolated spinal cord microglia to define their activation in vivo. Analysis resting identified 29 genes distinguish from other peripheral macrophages/monocytes. We then analyzed molecular changes during neurodegenerative disease using SOD1G93A mouse model amyotrophic lateral sclerosis (ALS). found not derived infiltrating...
High epidermal growth factor receptor (EGFR) gene copy number is associated with poor prognosis in lung cancer, but such findings have not been reported for HNSCC. A better understanding of the EGFR pathway may improve use inhibitors HNSCC.EGFR status was analyzed 86 tumor samples from 82 HNSCC patients by fluorescent situ hybridization (FISH) to determine number, polymerase chain reaction and direct sequencing activating mutations, DNA microarray immunohistochemistry RNA protein expression....
Diffuse large B-cell lymphoma (DLBCL) is the most common form of in adults. The disease exhibits a striking heterogeneity gene expression profiles and clinical outcomes, but its genetic causes remain to be fully defined. Through whole genome exome sequencing, we characterized diversity DLBCL. In all, sequenced 73 DLBCL primary tumors (34 with matched normal DNA). Separately, exomes 21 cell lines. We identified 322 cancer genes that were recurrently mutated DLBCLs. recurrent mutations...
Abstract Two‐dimensional difference gel electrophoresis (2‐D DIGE) coupled with mass spectrometry (MS) was used to investigate tumor‐specific changes in the proteome of human colorectal cancers and adjacent normal mucosa. For each six patients different stages colon cancer, Cy5‐labeled proteins isolated from tumor tissue were combined Cy3‐labeled neighboring mucosa separated on same 2‐D along a Cy2‐labeled mixture all 12 normal/tumor samples as an internal standard. Over 1500 protein...
Abstract Background The expression of carcino-embryonic antigen by colorectal cancer is an example oncogenic activation embryonic gene expression. Hypothesizing that oncogenesis-recapitulating-ontogenesis may represent a broad programmatic commitment, we compared patterns human cancers (CRCs) and mouse colon tumor models to those development days 13.5-18.5. Results We report here 39 tumors from four independent 100 CRCs encompassing all clinical stages shared striking recapitulation Compared...
Mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. To test whether exosomal RNAs also contribute to changes in gene expression recipient cells, and mutant might regulate composition of secreted microRNAs (miRNAs), we compared small matched from isogenic CRC cell lines differing only status. We show profiles are distinct cellular profiles, cluster separately wild-type exosomes. miR-10b was selectively increased exosomes, while...