A5101982961- Congenital heart defects research
- Genomic variations and chromosomal abnormalities
- MicroRNA in disease regulation
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- RNA Research and Splicing
- Genomics and Rare Diseases
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Circular RNAs in diseases
- Cardiac Fibrosis and Remodeling
- Receptor Mechanisms and Signaling
- Genomics and Chromatin Dynamics
- Photosynthetic Processes and Mechanisms
- RNA regulation and disease
- Algal biology and biofuel production
- Gene expression and cancer classification
- Pluripotent Stem Cells Research
- Autism Spectrum Disorder Research
- Sarcoma Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Venomous Animal Envenomation and Studies
- Cancer, Lipids, and Metabolism
Columbia University
2015-2025
Beijing University of Chemical Technology
2025
Columbia College
2024-2025
Royal College of Physicians
2024-2025
Stavros Niarchos Foundation
2025
First Affiliated Hospital of Anhui Medical University
2017-2024
Anhui Medical University
2017-2024
Columbia University Irving Medical Center
2011-2024
New York Psychoanalytic Society and Institute
2019-2024
New York State Psychiatric Institute
2017-2024
Individuals with 22q11.2 microdeletions have cognitive and behavioral impairments the highest known genetic risk for developing schizophrenia. One gene disrupted by microdeletion is DGCR8 , a component of “microprocessor” complex that essential microRNA production, resulting in abnormal processing specific brain miRNAs working memory deficits. Here, we determine effect Dgcr8 deficiency on structure function cortical circuits assessing their laminar organization, as well neuronal morphology,...
To elucidate the genetic architecture of familial schizophrenia we combine linkage analysis with studies fine-level chromosomal variation in families recruited from Afrikaner population South Africa. We demonstrate that individually rare inherited copy number variants (CNVs) are more frequent cases as compared to unaffected controls and affect almost exclusively genic regions. Interestingly, find while prevalence structural is similar sporadic cases, type markedly different. In addition,...
Dysregulation of microRNAs has been implicated in many cardiovascular diseases including fibrosis.Here we report that miR-433 was consistently elevated three models heart disease with prominent cardiac fibrosis, and enriched fibroblasts compared to cardiomyocytes.Forced expression neonatal rat increased proliferation their differentiation into myofibroblasts as determined by EdU incorporation, α-SMA staining, levels fibrosis-associated genes.Conversely, inhibition exhibited opposite...
We used a mouse model of the schizophrenia-predisposing 22q11.2 microdeletion to evaluate how this genetic lesion affects cortical neural circuits at synaptic, cellular, and molecular levels. Guided by cognitive deficits, we demonstrated that mutant mice display robust deficits in high-frequency synaptic transmission short-term plasticity (synaptic depression potentiation), as well alterations long-term dendritic spine stability. Apart from previously reported reduction complexity layer 5...
Abstract We utilized forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form Autism Spectrum Disorder (ASD) homozygous protein-truncating mutation in CNTNAP2 , to study its effects on embryonic cortical development. Patients this present clinical characteristics brain overgrowth. Patient-derived displayed an increase volume and total cell number that is driven by increased neural progenitor proliferation. Single-cell RNA sequencing revealed...
Abstract The present study was designed to explore the biological role of resveratrol (RES) in rheumatoid arthritis (RA) and underlying mechanism. adjuvant‐induced arthritic rats were administered RES on 12th day after model establishment, then assessment, oxidative stress measurement, histological examination, immunohistochemical staining performed. primary rat fibroblast‐like synoviocytes (FLS) isolated treated with vitro cell proliferation apoptosis assay examined. Chromatin...
There is accumulating evidence that AKT signaling plays a role in the pathogenesis of schizophrenia. We asked whether Akt1 deficiency mice results structural and functional abnormalities prefrontal cortex (PFC). Exploratory transcriptional profiling revealed concerted alterations expression PFC genes controlling synaptic function, neuronal development, myelination, actin polymerization, follow-up ultrastructural analysis identified consistent changes dendritic architecture pyramidal neurons....
We used a family-based cluster detection approach designed to localize significant rare disease-risk variants clusters within region of interest systematically search for schizophrenia (SCZ) susceptibility genes 49 genomic loci previously implicated by de novo copy number variants. Using two independent whole-exome sequencing family datasets and follow-up autism spectrum disorder (ASD) case/control dataset, we identified in one gene, Fanconi-associated nuclease 1 (FAN1), as being associated...
Using a genetic mouse model that faithfully recapitulates DISC1 alteration strongly associated with schizophrenia and other psychiatric disorders, we examined the impact of this mutation within prefrontal cortex. Although cortical layering, cytoarchitecture, proteome were found to be largely unaffected, electrophysiological examination mPFC revealed both neuronal hyperexcitability alterations in short-term synaptic plasticity consistent enhanced neurotransmitter release. Increased...
// Wenkang Luan 1, * , Rubo Li 2, Liang Liu 3, Xin Ni 4, Yan Shi 3 Yun Xia 1 Jinlong Wang Feng Lu and Bin Xu Department of Plastic Surgery, Affiliated People's Hospital Jiangsu University, Zhenjiang, China 2 Neurosurgery, Nanjing First Hospital, Medical Nanjing, 4 Gastroenterology, These authors have contributed equally to this work Correspondence to: Luan, email: luanwenkang@126.com Xu, xubinfen@126.com Keywords: malignant melanoma, ceRNA, HOTAIR, miR-152-3p, c-MET Received: April 15,...