A5044104772- Phosphodiesterase function and regulation
- Receptor Mechanisms and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Pharmacological Effects and Assays
- Neuropeptides and Animal Physiology
- Pharmaceutical Practices and Patient Outcomes
- Alzheimer's disease research and treatments
- Chemical synthesis and alkaloids
- Innovations in Medical Education
- Tryptophan and brain disorders
- Nitric Oxide and Endothelin Effects
- Health and Medical Research Impacts
- Education Systems and Policy
- Medicine and Dermatology Studies History
- Neurogenesis and neuroplasticity mechanisms
- Bipolar Disorder and Treatment
- Synthesis and Catalytic Reactions
- Pain Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Health Sciences Research and Education
- Patient Safety and Medication Errors
University at Buffalo, State University of New York
2014-2022
West Virginia University
2006-2019
Tetra Therapeutics (United States)
2019
Peking University
2019
Blanchette Rockefeller Neurosciences Institute
2019
Buffalo State University
2017
Johns Hopkins University
2017
Croydon University Hospital
2014
University of Iowa
2012-2013
Caesars Entertainment (United States)
2012
N6-methyladenosine (m6A) modification of RNA influences fundamental aspects metabolism and m6A dysregulation is implicated in various human diseases. In this study, we explored the potential role pathogenesis Alzheimer disease (AD).We investigated expression regulators brain tissues AD patients determined impact underlying mechanism manipulated levels on AD-related deficits both vitro vivo.We found decreased neuronal along with significantly reduced methyltransferase like 3 (METTL3) brains....
Phosphodiesterase-4 (PDE4) plays an important role in mediating memory via the control of intracellular cAMP signaling; inhibition PDE4 enhances memory. However, development inhibitors as enhancers has been hampered by their major side effect emesis. four subtypes (PDE4A–D) consisting 25 splice variants. Mice deficient PDE4D displayed enhancement radial arm maze, water and object recognition tests. These effects were mimicked repeated treatment with rolipram wild-type mice. In addition,...
The pathogenesis of several neuropsychiatric disorders, including anxiety and depression, has been linked to oxidative stress, in part via alterations cyclic nucleotide signaling. Phosphodiesterase-2 (PDE2), which regulates cGMP cAMP signaling, may affect anxiety-related behavior through reduction stress. present study evaluated the effects stress on assessed anxiolytic PDE2 inhibitor Bay 60-7550 [(2-(3,4-dimethoxybenzyl)-7-{(1R)-1-[(1R)-1-hydroxyethyl]-4-phenylbutyl}-5-methyl...
Chronic musculoskeletal pain is a significant health problem and associated with increases in during acute physical activity. Regular activity protective against many chronic diseases; however, it unknown if plays role development of pain. The current study induced by placing running wheels home cages mice for 5 days or 8 wk compared these to sedentary without their cages. muscle was repeated intramuscular injection pH 4.0 saline, exercise-enhanced combining 2-h fatiguing exercise task...
Resveratrol, a natural polyphenol found in red wine, has wide spectrum of pharmacological properties including antioxidative and antiaging activities. Beta amyloid peptides (Aβ) are known to involve cognitive impairment, neuroinflammatory apoptotic processes Alzheimer's disease (AD). Activation cAMP and/or cGMP activities can improve memory performance decrease the neuroinflammation apoptosis. However, it remains unknown whether enhancing effect resveratrol on AD associated disorders is...
The effects of antidepressant drugs in rats responding under a differential-reinforcement-of-low-rate 72-sec schedule were assessed. Seven clinically used tricyclic (imipramine, desipramine, chlorimipramine, protriptyline, nortriptyline, amitriptyline and doxepin), two atypical antidepressants (iprindole mianserin) monoamine oxidase inhibitor (tranylcypromine) dose-dependently reduced response rate increased reinforcement rate. Nomifensine, an which has been reported to have psychomotor...
Carefully designed animal models of genetic risk factors are likely to aid our understanding the pathogenesis schizophrenia. Here, we study a mouse strain with truncating lesion in endogenous Disc1 ortholog model effects schizophrenia-predisposing mutation and offer detailed account consequences that this has on development function hippocampal circuit. We uncover widespread cumulative cytoarchitectural alterations dentate gyrus during neonatal adult neurogenesis, which include errors axonal...
Abstract Single‐housed stress elicits a range of social isolation‐related behavioral and neurobiological abnormalities. To investigate single housing‐induced changes sex differences on outcomes, we examined single‐housed stress‐induced learning memory impairment, depression‐like behaviors, neuroplasticity abnormalities underlying mechanism. The results showed that male female mice socially isolated for 8 weeks had significantly decreased acquisition, as demonstrated in the curve Morris water...
Inhibitors of phosphodiesterase-4 (PDE4) have beneficial effects on memory in preclinical and clinical studies. Development these drugs has stalled due to dose-limiting side nausea emesis. While use subtype-selective inhibitors (i.e., for PDE4A, B, or D) could overcome this issue, conservation the catalytic region, which classical bind, limits approach. The present study examined BPN14770, an allosteric inhibitor PDE4D, binds a primate-specific, N-terminal region. In mice engineered express...
Using a genetic mouse model that faithfully recapitulates DISC1 alteration strongly associated with schizophrenia and other psychiatric disorders, we examined the impact of this mutation within prefrontal cortex. Although cortical layering, cytoarchitecture, proteome were found to be largely unaffected, electrophysiological examination mPFC revealed both neuronal hyperexcitability alterations in short-term synaptic plasticity consistent enhanced neurotransmitter release. Increased...
Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on key regulatory domain, known as UCR2, opens closes over the catalytic site for cAMP hydrolysis. The design optimization lead compounds was based iterative analysis X-ray crystal structures combined with metabolite identification. Selectivity activated, dimeric form provided potent memory enhancing effects in mouse model novel...
Preface by Henry Giroux Rearticulating a Racial Identity: Creating Oppositional Spaces to Fight for Equality and Social Justice Christine Clark James O'Donnell Unthinking Whiteness, Rethinking Democracy: Critical Citizenship in Gringolandia Peter McLaren Lighting Candles the Dark: One Black Woman's Response White Anti-Racist Narratives Beverly Deniel Tatum Subverting Racism from Within: Linking Identity Activism Becky Thompson Transforming Received Categories: Discovering Cross-Border...