A5101505596- Phosphodiesterase function and regulation
- Cholinesterase and Neurodegenerative Diseases
- Receptor Mechanisms and Signaling
- Advanced Image and Video Retrieval Techniques
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Image Enhancement Techniques
- Alzheimer's disease research and treatments
- Pain Mechanisms and Treatments
- Advanced Vision and Imaging
- Advanced Data Compression Techniques
- Neuroendocrine regulation and behavior
- Image Retrieval and Classification Techniques
- RNA and protein synthesis mechanisms
- Chemical synthesis and alkaloids
- Neurological Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Image Processing Techniques and Applications
- Machine Learning in Bioinformatics
- Image and Object Detection Techniques
- Memory and Neural Mechanisms
- Phytochemistry and Biological Activities
- Computational Drug Discovery Methods
- Video Surveillance and Tracking Methods
University of Electronic Science and Technology of China
2012-2025
Sun Yat-sen University
2022
Fifth Affiliated Hospital of Sun Yat-sen University
2022
University of California, Irvine
2000-2022
Tsinghua University
2004-2021
Tongji University
2021
First Affiliated Hospital Zhejiang University
2020
Fudan University
2020
Harbin Medical University
2017
Fourth Affiliated Hospital of Harbin Medical University
2017
Phosphodiesterase-4 (PDE4) plays an important role in mediating memory via the control of intracellular cAMP signaling; inhibition PDE4 enhances memory. However, development inhibitors as enhancers has been hampered by their major side effect emesis. four subtypes (PDE4A–D) consisting 25 splice variants. Mice deficient PDE4D displayed enhancement radial arm maze, water and object recognition tests. These effects were mimicked repeated treatment with rolipram wild-type mice. In addition,...
Phosphodiesterase (PDE)-2 is a component of the nitric-oxide synthase (NOS)/guanylyl cyclase signaling pathway in brain. Given recent evidence that pharmacologically induced changes NO-cGMP can affect anxiety-related behaviors, effects PDE2 inhibitors (2-(3,4-dimethoxybenzyl)-7-det-5-methylimidazo-[5,1-<i>f</i>][1,2,4]triazin-4(3<i>H</i>)-one) (Bay 60-7550) and 3-(8-methoxy-1-methyl-2-oxo-7-phenyl-2,3-dihydro-1<i>H</i>-benzo[<i>e</i>][1,4]diazepin-5-yl)benzamide (ND7001), as well modulators...
Nitrogen dioxide (NO2) is one of the most important atmospheric pollutants and precursors acid rain, tropospheric ozone, aerosols. However, due to poor quality source data computing power models, current ground-level NO2 concentration lack either high-resolution coverage or full nation-wide coverage. This study estimates in China with national at relatively high spatiotemporal resolution (0.25°; daily intervals) over newest past 6 years (2013–2018). We developed an advanced model, named...
In recent years, numerous advanced lightweight models have been proposed for salient object detection (SOD) in optical remote sensing images (ORSI). However, most methods still face challenges such as performance limitations and imbalances between accuracy computational cost. To address these issues, we propose SggNet, a novel semantic- graph-guided network ORSI-SOD. The SggNet adopts classical encoder-decoder structure with MobileNet-V2 the backbone, ensuring optimal parameter utilization....
Summary Background Environmental enrichment ( EE ) has been shown to enhance cognitive function in mouse models of Alzheimer's disease AD ). Magnesium‐L‐threonate (MgT) is a compound with newly discovered effect rescue learning and memory aging mice. Aim To study the additive therapeutic combined MgT EM potential mechanism underlying effects. Materials Methods APP / PS 1 mice were treated , MgT, or combination compared for restored function. Results was more effective improving cognition...
Abstract Background Certain endogenous metabolites can influence the rate of cancer cell growth. For example, diacylglycerol, ceramides and sphingosine, NAD + arginine exert this effect by acting as signaling molecules, while carrying out other important cellular functions. Metabolites also be involved in control proliferation directly regulating gene expression ways that are pathway-independent, e.g. direct activation transcription factors or inducing epigenetic processes. The fact affect...
Shadow detection is an essential research topic in the remote-sensing domain, as presence of shadow causes loss ground-object information real areas. It hard to define specific threshold values for identification areas with existing unsupervised approaches due complexity scenes. In this study, adaptive unsupervised-shadow-detection method based on multichannel features proposed, which can adaptively distinguish different First, new were designed hue, saturation, and intensity color space,...
Abstract Alternative translation is an important cellular mechanism contributing to the generation of proteins and diversity protein functions. Instead studying individual cases, we systematically analyzed alteration subcellular location domain formation by alternative translational initiation in eukaryotes. The results revealed that 85.7% events generated biological diversity, attributed different localizations distinct contents isoforms. Analysis isoelectric point values most N‐terminal...