A5018256607- RNA and protein synthesis mechanisms
- DNA and Nucleic Acid Chemistry
- RNA modifications and cancer
- RNA Research and Splicing
- Nuclear physics research studies
- Advanced biosensing and bioanalysis techniques
- Nuclear Physics and Applications
- Bacteriophages and microbial interactions
- RNA Interference and Gene Delivery
- Gamma-ray bursts and supernovae
- Protein Structure and Dynamics
- COVID-19 Clinical Research Studies
- Astro and Planetary Science
- Esophageal and GI Pathology
- Genomics and Phylogenetic Studies
- Complex Network Analysis Techniques
- X-ray Spectroscopy and Fluorescence Analysis
- Astrophysical Phenomena and Observations
- SARS-CoV-2 and COVID-19 Research
- Mass Spectrometry Techniques and Applications
- Robotics and Sensor-Based Localization
- Bacterial Genetics and Biotechnology
- Particle physics theoretical and experimental studies
- Kruppel-like factors research
- Advanced Photocatalysis Techniques
University at Albany, State University of New York
2016-2025
Albany State University
2016-2025
Duke Medical Center
2024
NYU Langone Health
2023-2024
University of Massachusetts Amherst
2024
New York University
2021-2024
Columbia University
2023
McMaster University
2006-2023
Max Biopharma (United States)
2023
University of California, Berkeley
2023
Covid-19 in Immune-Mediated Inflammatory Diseases The authors describe patients New York City with known immune-mediated inflammatory disease whom developed while they were receiving...
The monovalent ion parameters used by the AMBER-99 forcefield are shown to exhibit physically inaccurate behavior in molecular dynamics simulations of strong 1:1 electrolytes. These errors arise from an ad hoc adaptation Åqvist's cation parameters. result is rapid formation large, unphysical clusters at concentrations that well below solubility limits. observed poses a serious challenge for simulating ions around highly charged polymers such as nucleic acids. In this communication, we...
Objective To characterize the hospitalization and death rates among patients with inflammatory arthritis (IA) affected by coronavirus disease 2019 (COVID-19) to analyze associations of comorbidities immunomodulatory medications infection outcomes. Methods Data on clinical demographic features, maintenance treatment, course, outcomes in individuals IA (rheumatoid spondyloarthritis) symptomatic COVID-19 were prospectively assessed via web-based questionnaire followed individual phone calls...
Aqueous solutions of 1:1 strong electrolytes are considered to be the prototype for complete ionic dissociation. Nonetheless, clustering has been widely reported in all atom molecular dynamics simulations, and their presence is indirectly implicated a diverse range experimental results. Is there physical basis nonidealities such as ion pairing cluster formation aqueous electrolytes? We attempt answer this question by direct comparison results from detailed simulations experimentally observed...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganometallic Electrochemistry. II. Carbanion StabilitiesRaymond E. Dessy, William Kitching, Theodore Psarras, Rudolf Salinger, Alan Chen, and Tristram ChiversCite this: J. Am. Chem. Soc. 1966, 88, 3, 460–467Publication Date (Print):February 1, 1966Publication History Published online1 May 2002Published inissue 1 February 1966https://pubs.acs.org/doi/10.1021/ja00955a014https://doi.org/10.1021/ja00955a014research-articleACS PublicationsRequest...
RNA folds cotranscriptionally to traverse out-of-equilibrium intermediate structures that are important for function in the context of gene regulation. To investigate this process, here we study structure and Bacillus subtilis yxjA purine riboswitch, a transcriptional riboswitch downregulates nucleoside transporter response binding guanine. Although aptamer expression platform domain sequences do not completely overlap, hypothesized strand exchange process triggers its structural switching...
Base stacking interactions between adjacent bases in DNA and RNA are important for many biological processes biotechnology applications. Previous work has estimated energies pairs of bases, but contributions individual remained unknown. Here, we use a Centrifuge Force Microscope high-throughput single molecule experiments to measure bases. We found strongest purines (G|A at -2.3 ± 0.2 kcal/mol) weakest pyrimidines (C|T -0.5 0.1 kcal/mol). Hybrid with phosphorylated, methylated, nucleotides...
In just over a decade since its discovery, research on graphene has exploded due to number of potential applications in electronics, materials, and medicine. water-soluble form oxide, the material shown promise as biosensor preferential absorption single-stranded polynucleotides fluorescence quenching properties. The rational design these biosensors, however, requires an improved understanding binding thermodynamics ultimately predictive model sequence-specific binding. Toward goals, here we...
Significance We report a multistate folding free-energy landscape for hyperstable RNA tetraloop obtained from high-performance molecular dynamic simulations under multiple temperature and pressure conditions. These studies advance previous successes of de novo tetraloops our understanding the folded basic motifs. In addition to canonical A-RNA conformation, analysis describes left-handed Z-RNA conformation formation purine Triplet, each showing differential stabilization as function...
DNA nanotechnology uses the programmable assembly of to create nanoscale objects. Recent work from our laboratory suggested that terminal stacking interactions between adjacent strands could be a design parameter for nanotechnology. Here, we explore idea by creating tetrahedra with sticky ends containing identical base pairing but different interactions. Testing all 16 combinations, found melting temperature varied up 10 °C altering single stack in design. We also show 4 bp end weak does not...
The ideal aeronautical solid-state fuel should possess a high density (more thrust per Newton’s Third Law), gravimetric heat of combustion energy for less weight), and volumetric room mission-critical items). In this work, manganese diboride (MnB2) demonstrates 5.3 g/cm3, 38.30 kJ/g, the highest any known 202.99 kJ /cm3. When compared to currently used in Space Shuttle rocket boosters Launch System, aluminum metal, MnB2 represents 100% increase density, 23% combustion, 141% combustion....
A central question in biology is how RNA sequence changes influence dynamic conformational during cotranscriptional folding. Here we investigated this through the study of transcriptional fluoride riboswitches, non-coding RNAs that sense anion coordinated folding and rearrangement a pseudoknotted aptamer domain downstream intrinsic terminator expression platform. Using combination Escherichia coli polymerase vitro transcription cellular gene assays, characterized function mesophilic...