A5072667881- Virus-based gene therapy research
- Biochemical Acid Research Studies
- Metabolism and Genetic Disorders
- CRISPR and Genetic Engineering
- Biochemical and Molecular Research
- RNA Interference and Gene Delivery
- Viral Infectious Diseases and Gene Expression in Insects
- Glycogen Storage Diseases and Myoclonus
- Geochemistry and Geologic Mapping
- HIV Research and Treatment
- Herpesvirus Infections and Treatments
- SARS-CoV-2 detection and testing
- CAR-T cell therapy research
- Geological and Geochemical Analysis
- Computational Drug Discovery Methods
- Respiratory viral infections research
- Geomagnetism and Paleomagnetism Studies
- Protein purification and stability
- Innovative Microfluidic and Catalytic Techniques Innovation
- Immunotherapy and Immune Responses
- Viral Infections and Immunology Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cytomegalovirus and herpesvirus research
Max Biopharma (United States)
2023-2024
Lanzhou University
2024
China Geological Survey
2024
Bayer (United States)
2015-2018
Kansas State University
1995-2001
Micromolar Ca2+ facilitates ∼10-fold enhancement of pyruvate dehydrogenase phosphatase (PDP) activity by aiding the association PDP with dihydrolipoyl acetyltransferase (E2) component. Connected linker regions, E2 consists two lipoyl domains, NH2-lipoyl domain (L1) and interior (L2), a component binding surrounding 60-mer inner core. Using recombinant constructs L1 or L2, E2-enhanced was markedly decreased L2 but not L1, effectively competing intact in Ca2+-dependent (half-maximal reduction...
Introduction Recombinant adeno-associated virus (rAAV) vectors provide a safe and efficient means for in vivo gene delivery, although its large-scale production remains challenging. Featuring high manufacturing speed, flexible product design, inherent safety scalability, the baculovirus/Sf9 cell system offers practical solution to of rAAV large quantities purity. Nonetheless, removal inactivation recombinant baculoviruses during downstream purification remain critical prior clinical...
Introduction Angiotensin converting-enzyme 2 (ACE2) is an enzyme catalyzing the conversion of angiotensin into 1-7. ACE2 also serves as receptor several coronaviruses, including SARS-CoV-1 and SARS-CoV-2. Therefore, could be utilized a therapeutic target for treating these ideally lacking enzymatic function. Methods Based on structural analysis, specific mutations were introduced to generate mutants ACE2-Fc (fusion protein Fc region IgG1). The activity, binding affinity, neutralization...
Iron isotope ratios in magnetite have been widely used to reveal critical geological and biological processes. Laser ablation multi‐collector inductively coupled plasma‐mass spectrometry (LA‐MC‐ICP‐MS) is ideally suited for measurement of Fe ratios, however the lack suitable reference materials poses a significant challenge situ isotopic measurements magnetites. In this study, five high‐quality natural crystals were characterised using solution nebulisation (SN)‐MC‐ICP‐MS LA‐MC‐ICP‐MS. The...