A5057383804- COVID-19 Clinical Research Studies
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- COVID-19 diagnosis using AI
- Viral-associated cancers and disorders
- Renal cell carcinoma treatment
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Immunotherapy and Immune Responses
- Mycobacterium research and diagnosis
- Phytochemicals and Antioxidant Activities
- Computational Drug Discovery Methods
- Sinusitis and nasal conditions
- Inflammasome and immune disorders
- Luminescence and Fluorescent Materials
- Chromatography in Natural Products
- CAR-T cell therapy research
- vaccines and immunoinformatics approaches
- Cardiac tumors and thrombi
- Pharmacological Effects of Natural Compounds
- Transplantation: Methods and Outcomes
- Cancer Mechanisms and Therapy
- Carbon and Quantum Dots Applications
- COVID-19 Impact on Reproduction
Zhongnan Hospital of Wuhan University
2019-2024
Wuhan University
2019-2024
Weatherford College
2024
Xianning Central Hospital
2020-2024
Hubei University of Science and Technology
2021-2024
Max Biopharma (United States)
2024
Shanghai Jiao Tong University
2020
Harbin Medical University
2020
Renji Hospital
2020
The Fourth People's Hospital
2020
Abstract Background Suanzaoren Decoction (SZRD), a well-known formula from traditional Chinese medicine, has been shown to have reasonable cognitive effects while relaxing and alleviating insomnia. Several studies demonstrated significant therapeutic of SZRD on diabetes Alzheimer’s disease (AD). However, the active ingredients probable processes in treating with are unknown. This study aims preliminarily elucidate potential mechanisms treatment diabetes. Methods The main components...
Objective To investigate the computed tomography (CT) characteristics and diagnostic value of novel coronavirus pneumonia (NCP or COVID-19) in pregnancy. Methods This study included ten pregnant women infected with COVID-19, treated Zhongnan Hospital Wuhan University from January 20, 2020 to February 6, 2020. Clinical chest CT data were collected clinical symptoms, laboratory indicators, images analyzed explore for COVID-19 during Results Laboratory examination showed that white blood cell...
Background. Vacuolar protein sorting 16 (VPS16) overexpression was recently considered related to cancer growth and drug resistance; however, little is known about whether VPS16 plays a vital role in liver hepatocellular carcinoma (LIHC). Methods. The TIMER2 online database used analyze the expression of pancancer, Xena Browser explore correlation between level survival time. R language test data 374 LIHC cases TCGA database. DESeq2 for differentially expressed gene (DEG) analysis. HPA...
The purpose of this study was to investigate the expression pyroptosis-related factors (NLRP3, IL-18, NF-κB, HMGB-1, and GSDMD) in patients who died COVID-19. levels NLRP3, GSDMD lung spleen tissues COVID-19 group control were detected by tissue immunofluorescence. includes two unexpectedly without SARS-CoV-2 infection, three virus infection. positive rates from 9.8% vs 73.4% ( p = 0.000), 5.5% 63.6% 24.4% 76.2% 17.5% 46.8% 0.000) respectively. 20.6% 71.2% 18.9% 72.0% 15.2% 64.8% 27.6% 69.2%...
The report states a case of pituitary fossa aspergillus abscess without invasion in AIDS patient. A 50-year-old patient was admitted with headache, vomiting, dizziness and weakness. sellar mass found to be simulated tumor after imaging examination, operated on via an endoscopic trans-sphenoidal approach. After the necrotic material removed, intact found. Histopathology revealed numerous hyphae. Aspergillus should considered differential diagnosis mass.
Kidney renal papillary cell carcinoma (KIRP) is a common urinary tumor that causes lymph node invasion. Once metastatic, the prognosis poor and there lack of effective early diagnostic markers for this tumor. The expression CCNB1 in KIRP tissues was significantly higher than normal Cancer Genome Atlas database with or without genotype-tissue database, consistent result obtained 32 paired tissues. In addition, increased remarkably progression T M stages. Moreover, using online HPA we verified...
Introduction Angiotensin converting-enzyme 2 (ACE2) is an enzyme catalyzing the conversion of angiotensin into 1-7. ACE2 also serves as receptor several coronaviruses, including SARS-CoV-1 and SARS-CoV-2. Therefore, could be utilized a therapeutic target for treating these ideally lacking enzymatic function. Methods Based on structural analysis, specific mutations were introduced to generate mutants ACE2-Fc (fusion protein Fc region IgG1). The activity, binding affinity, neutralization...
Abstract Kidney renal papillary cell carcinoma (KIRP) is a common tumor in the urinary system, which easy to cause lymph node invasion. Once metastatic, prognosis poor, and there lack of effective early diagnostic markers for this tumor. We used R language process data from TCGA GTEx combined with multiple online databases. Sensitive drugs targeting CCNB1 were screened out by ‘pRRophetic’ package molecular docking technology. Our indicated that expression level KIRP was significantly higher...
BACKGROUND: Non-Hodgkin’s lymphoma (NHL) has a poor prognosis and serious risk of mortality. Furthermore, the clinical imaging characteristics differ between human immunodeficiency virus (HIV)-positive HIV-negative NHL. We aimed to create nomogram based on imaging, clinical, laboratory indicators predict mortality patients with HIV-positive MATERIALS AND METHODS: A total 306 were enrolled. The training cohort comprised 194 NHL treated at four Chinese medical centers April 2012 October 2020....
Background Hypoxic‐ischemic (HI) brain injury is a leading cause of neonatal mortality and, in survivors, severe neurological disability and it major source developmental cognitive impairments children adults. In HI, pathways include excitotoxicity, inflammation, oxidative stress. The carotenoid lutein (and its isomer zeaxanthin) are selectively taken up accumulated the brain. Based on effects improving later life cognition, we postulated may have neuroprotective HI. Methods We used...
Objective To summarize the computed tomographic (CT) manifestations of pulmonary aspergillosis after organ transplantation and compare different signs between bacterial pneumonia. Methods CT images (n=62) pneumonia (n=68) in post-transplantation patients were reviewed. The categorized with consolidation, mass, large nodule (≥1cm), small bud-in-tree pattern. Some detailed useful differentiating such as halo sign, air bronchogram reversed hypodensity sign cavitation also...
Abstract Background: In December 2019, a cluster of patients with pneumonia unknown cause was linked to seafood wholesale market in Wuhan, China. A novel coronavirus detected, capable infecting humans, on 6 January 2020 and termed COVID-19. By 16 February 2020, there were 51857 confirmed cases 2019-nCoV (COVID-19) 25 countries. COVID-19 can also lead acute respiratory distress syndrome (ARDS). Methods: 149 2019 Novel Coronavirus (COVID-19)pneumonia(68 males, 81 females, ages 1-89)from...
OBJECTIVE: To analyze the clinical characteristics, pathological and prognostic factors of AIDS-related lymphoma (ARL). MATERIALS AND METHODS: This was a retrospective study diagnosis treatment process, survival status 32 patients with ARL. The were divided into group nonsurvival according to their prognosis, affecting analyzed. patients' characteristics analyzed symptoms, sex, age, laboratory indicators such as lactate dehydrogenase (LDH) concentration, number CD4+ T cells, Ann Arbor stage,...