A5086497534- Neonatal Respiratory Health Research
- Antioxidant Activity and Oxidative Stress
- Congenital Diaphragmatic Hernia Studies
- Retinoids in leukemia and cellular processes
- Birth, Development, and Health
- Cancer, Lipids, and Metabolism
- Pregnancy and preeclampsia studies
- Cancer, Hypoxia, and Metabolism
- Prenatal Screening and Diagnostics
- Infant Nutrition and Health
- Retinal Diseases and Treatments
- Neuroscience of respiration and sleep
- Fibroblast Growth Factor Research
- Respiratory Support and Mechanisms
- Retinopathy of Prematurity Studies
- Mitochondrial Function and Pathology
- Neonatal Health and Biochemistry
- Parathyroid Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Bone health and treatments
- Congenital Heart Disease Studies
- Hemoglobinopathies and Related Disorders
- solar cell performance optimization
- Ethics and Legal Issues in Pediatric Healthcare
- Infant Development and Preterm Care
Texas Tech University
2013-2023
Texas Tech University Health Sciences Center
2013-2023
Cleveland Clinic Lerner College of Medicine
2023
Children’s Institute
2023
Georgetown University
2019-2023
MedStar Georgetown University Hospital
2022-2023
Georgetown University Medical Center
2019-2022
El Paso Children's Hospital
2016
Cleveland Clinic
2006-2015
Brookdale University Hospital and Medical Center
2015
Increasing evidence suggests that dietary carotenoids may reduce the risk of breast cancer. However, anti-breast cancer effects have been controversial, albeit understudied. Here, we investigated specific on a wide range cell lines, and found among several (including β-carotene, lutein, astaxanthin), lutein significantly inhibits growth by inducing cell-cycle arrest caspase-independent death, but it has little effect primary mammary epithelial cells (PmECs). Moreover, lutein-mediated...
Most studies of circulating PTH levels using traditional RIAs have supported the concept physiological hyperparathyroidism pregnancy, with pregnant women having serum immunoreactive significantly higher than those in nonpregnant subjects. However, such are insensitive and often detect inactive fragments, so that correlation between immunoreactivity bioactivity is poor. Employing a new intact immunoradiometric assay (Allegro-Nichols), we reassessed effects pregnancy on parathyroid function....
Functional maturation of pulmonary alveolar epithelial cells is crucial for extrauterine survival. Mechanical distension and mesenchymal-epithelial interactions play important roles in this process. We hypothesized that mechanical stretch simulating fetal breathing movements an regulator cell differentiation. Using a Flexercell Strain Unit, we analyzed effects on primary cultures type II cocultures mesenchymal isolated from rat lungs during late development. Cyclic increased surfactant...
Retinal pigment epithelial (RPE) cells are central to retinal health and homoeostasis. Oxidative stress-induced damage the RPE occurs as part of pathogenesis age-related macular degeneration neovascular retinopathies (e.g., retinopathy prematurity, diabetic retinopathy). The xanthophyll carotenoids, lutein zeaxanthin, selectively taken up by RPE, preferentially accumulated in human macula, transferred photoreceptors. These xanthophylls protect macula (and broader retina) via their...
Despite numerous inquiries into protective roles of lycopene in prostate cancer prevention or therapy, little is known about mechanisms by which its metabolites inhibit cancer. The enzyme β-carotene 9',10'-oxygenase (BCO2), catalyzes asymmetric cleavage several carotenoids, the principal regulator metabolism, but range BCO2 biological functions incompletely understood. This study investigated expression and functional human Expression bco2 gene dramatically decreased tissue a cell lines as...
The placenta expresses high levels of 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) that converts cortisol into inactive 11-keto metabolites and effectively protects the developing fetus from maternal during pregnancy. Impairment this glucocorticoid barrier has adverse effects on fetal outcomes. A similar spectrum is induced by antenatal stress To examine hypothesis physiological may regulate placental 11βHSD2 gene expression, we examined catecholamines norepinephrine (NE) epinephrine...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Abstract Parathyroid hormone‐related protein (PTHrP) and PTH/PTHrP receptor expression are developmentally regulated in lung epithelium adepithelial mesenchyme, respectively. To test the hypothesis that PTHrP is a developmental regulator of terminal airway development, we investigated vivo vitro models alveolar cytodifferentiation using mice which gene encoding was ablated by homologous recombination. We have determined fetal newborn PTHrP(−/−) lungs showed delayed mesenchymal–epithelial...
Development of the pulmonary air sacs is crucial for extrauterine survival. Late fetal lung development characterized by a thinning mesenchyme, which brings pneumocytes and endothelial cells into apposition. We hypothesized that mechanical stretch, simulating breathing movements, plays an important role in this remodeling process. Using Flexercell Strain Unit, we analyzed effects intermittent stretch on cell proliferation apoptosis activation fibroblasts isolated from rat lungs during late...
Carotenoids are a class of phytochemical compounds found in variety fruits and vegetables (F/V) and, therefore, commonly used as biomarker for F/V intake. The Veggie Meter
Alpha-thalassemia is one of the most common genetic disorders in world and becoming more United States with increase immigration susceptible populations. This disease has been stated previously to be incompatible extrauterine life.A Filipino woman a prior loss due hemoglobin Bart's underwent prenatal diagnosis that confirmed recurrence index pregnancy. Intravascular intrauterine exchange transfusions maintained appropriate fetal growth. A cesarean delivery yielded 2190-g male infant minor...
<h3>Objectives</h3> To compare rates of narcotic administration for medically treated neonates in different neonatal intensive care units (NICUs) and to untreated assess whether narcotics provided advantages or disadvantages short-term outcomes, such as cardiovascular stability (ie, blood pressure heart rate), hyperbilirubinemia, duration respiratory support, growth, the incidence intraventricular hemorrhage. <h3>Study Design</h3> The medical charts weighing less than 1500 g, admitted 6...