A5103158371- Lipid metabolism and biosynthesis
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Genetic and phenotypic traits in livestock
- Ovarian function and disorders
- Adipose Tissue and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Nanoplatforms for cancer theranostics
- Inflammatory mediators and NSAID effects
- Reproductive System and Pregnancy
- COVID-19 diagnosis using AI
- Peroxisome Proliferator-Activated Receptors
- Composting and Vermicomposting Techniques
- Advanced Sensor Technologies Research
- Influenza Virus Research Studies
- Plant tissue culture and regeneration
- Cholesterol and Lipid Metabolism
- Education and Work Dynamics
- Ear Surgery and Otitis Media
- Photodynamic Therapy Research Studies
- Algal biology and biofuel production
- Prosthetics and Rehabilitation Robotics
- Multisensory perception and integration
- Neonatal and fetal brain pathology
- Bone Metabolism and Diseases
First Affiliated Hospital of Jiangxi Medical College
2025
Nanchang University
2023-2025
Shandong University
2024-2025
Beijing Forestry University
2025
Guiyang Medical University
2024
Anhui University
2023
Hefei University of Technology
2023
ZheJiang Academy of Agricultural Sciences
2022
Northwest A&F University
2014-2022
Tsinghua University
2022
Acetaminophen (APAP) is the most common cause of drug-induced liver injury (DILI); however, treatment options are limited. Mas a G protein-coupled receptor whose role in APAP-induced hepatotoxicity has not yet been examined.Intrahepatic expression was determined both human and mouse DILI models. Mas1-/-, AlbcreMas1f/f, Ppara-/-, Mas1-/-Ppara-/- wild-type mice were challenged with APAP for vivo analyses Mas-AKT-FOXO1 axis-dependent lipophagy fatty acid oxidation (FAO), using pharmacological...
Abstract Premature ovarian failure (POF) caused by chemotherapy is a growing concern for female reproductive health. The use of metformin (MET), which has anti-oxidative and anti-inflammatory effects, in the treatment POF damaged drugs remains unclear. In this study, we investigated impact MET on cyclophosphamide (CTX) combined with busulfan (BUS) M1 macrophages using model mice primary granule cells (GCs). Our findings demonstrate that intragastric administration ameliorates damage...
The application of additives to regulate the microbial functional composition during composting has attracted much research attention. However, little is known about succession and role fungal community in laboratory-scale vegetable waste supplemented with pig manure agents. purpose this study was identify effective for improving performance product quality, analyze composting. results showed that combined addition agents (T2 treatment) accelerated pile temperature increase, enhanced total...
The aim of this study was to investigate the effects progesterone (PROG) on blood-brain barrier (BBB) permeability, cerebral edema and expression matrix metalloproteinase-9 (MMP-9) aquaporin-4 (AQP-4) in neonatal rats with hypoxic-ischemic brain damage (HIBD) explore mechanism its neuroprotective effect. Sixty 7-day-old Wistar were divided into sham surgery, hypoxic ischemia (HI) drug prophylaxis groups. HIBD animal models established. All animals sacrificed after 24 h. BBB assessed using...
Osteoarthritis (OA) is an age-related joint disease in which inflammation and extracellular matrix (ECM) degradation play a crucial role the destruction of articular cartilage. Secoisolariciresinol diglucoside (SDG), main lignan wholegrain flaxseed, has been reported to remarkably suppress oxidative stress, may have potential therapeutic value OA. In this study, effect mechanism SDG against cartilage degeneration were verified destabilization medial meniscus (DMM) collagen-induced (CIA)...
As one of the essential lignan derivative found in traditional Chinese medicinal herbs, secoisolariciresinol diglucoside (SDG) was proved to promote women's health through its phytoestrogenic properties. Increasingly studies indicated that this compound could be a potential drug capable preventing estrogen-related diseases. Here, we aimed investigate whether SDG can counteract cyclophosphamide (CTX) induced premature ovarian insufficiency (POI) and further explore specific molecular...
GOx-mediated glucose depletion offers an alternative noninvasive strategy for tumor therapy, but its lower catalytic activity in vivo limits clinical application. Herein, we designed a temperature-sensitive nano-GOx (NG) that was constructed by gold nanorods chemically modified with GOx (AuNRs-GOx) and coated lipids. The chemical linkage could maintain the natural conformation of GOx, ensuring NG exerted powerful within initiated antitumor immune response through moderate starvation mild...
Osteoarthritis (OA) is a chronic degenerative disease characterized by articular cartilage destruction and subchondral bone reconstruction in the early stages. Bergenin (Ber) cytoprotective polyphenol found many medicinal plants. It has been proven to have anti-inflammatory, antioxidant, other biological activities, which may reveal its potential role treatment of OA. This study aimed determine efficacy Ber treating OA explore possible underlying mechanism through network pharmacology...
The objective of this study was to investigate proliferator-activated receptor (PPARγ), fatty acid synthase (FAS) and hormone-sensitive lipase (HSL) mRNA protein expression in fat tails Tan sheep. Rams from different developmental stages (aged 3, 6, 9, 12, 15 18 months) were selected, their tail measurements including length (L), width (W) girth (G) recorded. expressions PPARγ, FAS HSL examined by quantitative real-time polymerase chain reaction (PCR) Western blot. increased with age. We...
Prosthetic knee is very important for the lower limb disabled people who want to walk normally. Based on instantaneous center rotation (ICR) of human knee, this paper presents an optimal design six-bar mechanism joint using genetic algorithm. The gait data normal are collected perform dynamic inverse calculation optimized prosthesis. simulation results demonstrate that proposed prosthesis has good performance gait. In future work, we will further develop models achieve balance and stability...
The effects of dietary nutrition on tail fat deposition and the correlation between production performance Hh signaling pathway OXCT1 were investigated in fat-tailed sheep. Tan sheep fed different nutritional diets variances length, width, thickness weight as well mRNA expression fat-related genes (C/EBPα, FAS, LPL, HSL) determined at three growth stages based their body weight. Furthermore, correlations phenotypes Hedgehog (Hh) components (IHH, PTCH1, SMO, GLI1) investigated. C/EBPα, HSL...
Cytopharmaceutical based on macrophages is a breakthrough in the field of targeted drug delivery. However, it remains challenge to localize and control release while retaining macrophage activity exerting its immunotherapeutic effect. Herein, localized light-triggered cytopharmaceutical (USIP@M) was proposed, which could utilize tumor targeting immunotherapy effects reverse immune suppression microenvironment (TME). Amphiphilic block copolymers with ultraviolet (UV)-responsive
Lipid droplets have attracted much attention due to their unique structure and key connections with various organelles in cells. Here, we constructed reactive oxygen species (ROS) platform, viz, TT2CN-anchored lipid droplets, by carefully designing photosensitizers (TT2CN) proper lipophilicity, excellent light stability cell imaging ability. Confocal fluorescence revealed the contact behavior of this ROS platform other its outstanding capability mediate multiple subcellular organelle damage....
Abstract Tungsten is an important material constituting the first wall of Experimental Advanced Superconducting Tokamak due to its excellent corrosion resistance. The temperature distribution during discharge process are key ensuring safe and stable operation EAST. Therefore, it necessary explore dependence emissivity on wavelength for improving measurement accuracy. This work quantitatively explores normal spectral tungsten within 3 μm 5 in range between 100°C 500°C based Fourier transform...
Abstract The incidence of premature ovarian failure (POF) is progressively escalating, with chemotherapy drugs identified as a significant contributing factor. Our study demonstrates that can induce abnormal inflammation and oxidative stress within the ovary, resulting in damage to granulosa cells (GCs), which may be cause POF. Furthermore, numerous studies have reported Metformin (MET) has various beneficial effects, including anti-aging, anti-oxidative stress, anti-inflammatory. Hence,...
the experiments, analyzed data, and wrote first draft.RD, YW, SG SL supported sampling genotyping of animals.XW, WH, XC