A5101423139- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Phytochemistry and biological activity of medicinal plants
- Extracellular vesicles in disease
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Genetic and phenotypic traits in livestock
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Data Mining Algorithms and Applications
- Cancer-related Molecular Pathways
- Bioactive Compounds and Antitumor Agents
- Chemokine receptors and signaling
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
- Osteoarthritis Treatment and Mechanisms
- Kruppel-like factors research
- Peroxisome Proliferator-Activated Receptors
- Genomics, phytochemicals, and oxidative stress
- Angiogenesis and VEGF in Cancer
Yancheng Institute of Technology
2024-2025
Northwestern Polytechnical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Institute of Hematology & Blood Diseases Hospital
2024
Xiamen University
2024
Nanjing University
2021-2024
Guangzhou Medical University
2014-2023
China University of Political Science and Law
2023
University of Manchester
2023
First Affiliated Hospital of Guangzhou Medical University
2016-2023
Background: Ovarian cancer is the most lethal female genital malignancy. Although cisplatin first-line chemotherapy to treat ovarian patients along with debulking surgeries, its efficacy limited due high incidence of resistance. ATP citrate lyase (ACLY) has been shown be a key metabolic enzyme and associated poor prognosis in various cancers, including cancer. Nevertheless, no studies have probed mechanistic relationship between ACLY Methods: Survival analysis was mainly carried out online....
Carbon emissions are critical to climate change, and land-use change is an essential source of growth in carbon emissions. Research on has become one the hotspots academic research. To explore research development trends last 20 years, CiteSpace software was used conduct a quantitative analysis relevant literature. This paper based China National Knowledge Infrastructure (CNKI) Web Science (WoS) database literature from 2001 2020. The scientific cooperation network software, with keyword...
Bromodomain and extra-terminal domain inhibitors like JQ1 have proved to be promising epigenetic agents for the treatment of malignant ovarian carcinoma. However, resistance cancer cells BET has not been elucidated. In this study, we investigated potential mechanisms underlying cell lines inhibitor JQ1.We evaluated apoptotic proliferative response four JQ1. The were designated as resistant (A2780 HO-8910) sensitive groups (SKOV-3 HEY). Further experiments detected different levels...
Although our previous studies have confirmed that 1, 3, 8-trihydroxy-6-methylant hraquinone (emodin) inhibits migration and invasion in epithelial ovarian cancer (EOC) cells, the underlying molecular mechanism remains unknown. Here, aim was to investigate effects of emodin on EOC cells study further this process, both vitro vivo.Cell proliferation evaluated by methylthiazolyl tetrazolium assay. Cell abilities were tested using transwell The expression integrin-linked kinase (ILK)...
Slow-cycling cancer cells (SCCs) with a quiescence-like phenotype are believed to perpetrate relapse and progression. However, the mechanisms that mediate SCC-derived tumor recurrence poorly understood. Here, we investigated underlying after chemotherapy, focusing on interplay between SCCs microenvironment. We established preclinical model of by exposing non-small-cell lung (NSCLC) either proliferation-dependent dye carboxyfluorescein diacetate succinimidyl ester (CFSE) or chemotherapeutic...
Tumor necrosis factor-alpha inhibitors, including infliximab and adalimumab, are effective medical treatments for perianal fistulising Crohn's disease (CD), but not all patients achieve fistula healing.To determine the correlation between healing closure with adalimumab trough levels.In this multicentre retrospective study conducted across four tertiary inflammatory bowel centres in Australia, we identified CD fistulae on maintenance or who had a level within twelve weeks of clinical...
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Despite anticancer capabilities of emodin observed in many cancers, including EOC, underlying molecular mechanism remains to be elucidated. A crucial link has been discovered between acquisition metastatic traits and epithelial-mesenchymal transition (EMT). The present study aimed determine whether could inhibit EMT EOC cells explore mechanism. CCK-8 assay transwell showed that effectively repressed abilities...
Abstract Liver cancer is now one of the most lethal and commonest cancers in world, among which over 90% hepatocellular carcinoma (HCC). Recent studies have confirmed long non-coding RNAs (lncRNAs) are implicated carcinogenesis. It has been reported lncRNA LINC00668 serves as an oncogene several cancers. However, mechanism where regulates HCC still unclear. qRT-PCR analysis was adopted to detect expression relative RNAs. Cytoplasmic nuclear RNA fraction conducted verify underlying molecular...
The combination of closed bipolar electrodes (cBPE) with electrochemiluminescence (ECL) imaging has demonstrated remarkable capabilities in the field bioanalysis. Here, we established a cBPE-ECL platform for ultrasensitive detection alkaline phosphatase (ALP) and two-dimensional epidermal growth factor receptor (EGFR). This system consists high-density gold nanowire array anodic aluminum oxide (AAO) membrane as cBPE coupled ECL highly luminescent cadmium selenide quantum dots (CdSe QDs)...
Almqvist C, Garden F, Kemp AS, Li Q, Crisafulli D, Tovey ER, Xuan W, Marks GB for the CAPS investigators. Effects of early cat or dog ownership on sensitisation and asthma in a high-risk cohort without disease-related modification exposure. Paediatric Perinatal Epidemiology 2010; 24: 171–178. Variation observed association between pet allergic disease may be attributable to selection bias confounding. The aim this study was suggest method assess exposure second examine how acquisition life...
Epithelial ovarian cancer (EOC) is the most lethal in female genital tumors. New disease markers and novel therapeutic strategies are urgent to identify considering current status of treatment. Receptor tyrosine kinases family plays critical roles embryo development progression. However, ambivalent research conclusions ROR2 make its role tumor confused underlying mechanism far from being understood. In this study, we sought clarify effects on high-grade serous carcinoma (HGSOC) cells reveal...