A5026088300- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- Protein Degradation and Inhibitors
- Autophagy in Disease and Therapy
- Genomics and Phylogenetic Studies
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Microbial Community Ecology and Physiology
- Endoplasmic Reticulum Stress and Disease
- Phagocytosis and Immune Regulation
- Fibroblast Growth Factor Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver physiology and pathology
- Pancreatic and Hepatic Oncology Research
- Connective Tissue Growth Factor Research
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Diabetes, Cardiovascular Risks, and Lipoproteins
Tongji Hospital
2022-2025
Tongji University
2022-2025
First Affiliated Hospital of Zhengzhou University
2019-2020
South China Normal University
2016
Bromodomain and extra-terminal domain inhibitors like JQ1 have proved to be promising epigenetic agents for the treatment of malignant ovarian carcinoma. However, resistance cancer cells BET has not been elucidated. In this study, we investigated potential mechanisms underlying cell lines inhibitor JQ1.We evaluated apoptotic proliferative response four JQ1. The were designated as resistant (A2780 HO-8910) sensitive groups (SKOV-3 HEY). Further experiments detected different levels...
A high diversity of pleurostomatid ciliates has been discovered in the last decade, and their systematics needs to be improved light new findings concerning morphology molecular phylogeny. In this work, a genus, Protolitonotus gen. n., two species, magnus sp. n. longus were studied. Furthermore, 19 novel nucleotide sequences SSU rDNA , LSU ITS 1‐5.8S‐ 2 collected determine phylogenetic relationships systematic positions study. Based on both morphological data, results demonstrated that: (i)...
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with high prevalence worldwide and poor prognosis. It has been verified that elongation very-long-chain fatty acids gene family (ELOVLs), group genes responsible for saturated polyunsaturated acids, participate in pathogenesis development multiplex disease including cancers. However, functions prognosis ELOVLs HCC are still indistinguishable. First, we searched mRNA expression survival data patients via The Cancer Genome...
Abstract The biological function and underlying mechanism of microRNA‐628‐5p (miR‐628‐5p) remains to be clarified in the growth progression pancreatic ductal adenocarcinoma (PDAC). Here, expression levels miR‐628‐5p PDAC tissues cells were detected by quantitative reverse transcriptase polymerase chain reaction situ hybridization. relationship between clinicopathologic characteristics was examined human tissue samples. Gain‐ loss‐of‐function putative targets evaluated cell lines. upstream...
Aim: The effects of different types gastric neuroendocrine tumors (G-NETs) on treatment strategy formulation and prognostic evaluation still remain controversial due to their rarity. Methods: 187 patients diagnosed with G-NETs were subdivided into four based the pathophysiology, etiology presentation. Results: Type I, II >1.0 cm type III, IV >2.0 are proved aggressive behavior (p < 0.05). III higher Ki-67 index tumor stage showed more invasive potential than I Endoscopic resection is primary...
The effect of non-jaundice stage at diagnosis on clinicopathological features and prognosis patients with periampullary carcinomas (PACs) remains uncertain.The 504 who were pathologically diagnosed PACs between 2012 2017 retrospective analyzed. Kaplan-Meier method was used to estimate survival log-rank tests for comparisons groups.Patients divided into the group jaundice according serum total bilirubin (3 mg/dL) diagnosis. By comparison group, more manifested abdominal pain longer duration....
Diabetes is a metabolic disease which has been confirmed to be involved with abnormal or excessive body fat accumulation. There still lack of nationwide research in China discuss the relationship between adiposity indicators included mass index (BMI), waist circumference (WC), visceral index, waist-height ratio, waist-to-hip ratio (WHR) and diabetes. The question one best indicator obesity predict diabetes remains unclear.Data were collected from Health Nutrition Survey (CHNS) 2009,...
Although the close relationship between nonalcoholic fatty liver disease (NAFLD) and insulin resistance has been clarified there is a five-fold higher prevalence of NAFLD in patients with diabetes compared to that without diabetes, this not reason focus only on incidence people because who are resistant necessarily diagnosed which leads overlook non-diabetic population. Actually, we obligated pay more attention population for early detection intervention NAFLD. There lack convenient tool...
Background Nonalcoholic fatty liver disease (NAFLD) is the most common worldwide that endangers human health. Transcription factors (TFs) have gradually become hot spots for drug development in NAFLD their impacts on metabolism. However, specific TFs regulate immune response of not clear. This study aimed to investigate involved and provide novel targets development. Methods Microarray data were obtained from samples 26 normal volunteers 109 patients using Gene Expression Omnibus (GEO)...
Objective To explore the clinicopathological characteristics of primary hepatic neuroendocrine neoplasm (HNEN) and metastatic HNEN from digestive tract, to screen risk factors metastasis gastroenteropancreatic (GEP-NEN) analyze differences between in clinical features, diagnosis, treatment prognosis. Methods From January 2010 June 2017, data 182 patients with admitted at The First Affiliated Hospital Zhengzhou University were retrospectively analyzed, including 39 cases HNEN, 129 14...
Hepatic neuroendocrine tumors (HNETs) are uncommon neoplasms that can be subdivided into 2 types: primary and metastatic HNETs. Due to its rarity, heterogeneity complexity, the diagnosis, treatment modalities prognosis still controversial.This retrospective study reviewed effects of tumor origins therapeutic options on gastroenteropancreatic with liver metastasis (GEP-NETLM) hepatic (PHNETs), providing additional evidence for clinicians evaluating patients.HNETs consisted PHNETs GEP-NETLM....