A5086704736- Spaceflight effects on biology
- Biosensors and Analytical Detection
- Nanoplatforms for cancer theranostics
- Gut microbiota and health
- Immune Cell Function and Interaction
- Immune cells in cancer
- Fungal Biology and Applications
- High Altitude and Hypoxia
- Hematopoietic Stem Cell Transplantation
- Advanced biosensing and bioanalysis techniques
- Hepatitis B Virus Studies
- Nanoparticle-Based Drug Delivery
- Viral gastroenteritis research and epidemiology
- Antimicrobial Peptides and Activities
- Probiotics and Fermented Foods
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cellular Mechanics and Interactions
- CRISPR and Genetic Engineering
- Cancer Cells and Metastasis
- Aquaculture disease management and microbiota
- 3D Printing in Biomedical Research
- Plant Disease Resistance and Genetics
- Advanced Sensor and Energy Harvesting Materials
- Phagocytosis and Immune Regulation
Ministry of Education of the People's Republic of China
2023-2025
Northwestern Polytechnical University
2016-2025
Northwest A&F University
2025
Jilin University
2025
Northwest University
2025
First Hospital of Jilin University
2025
Hainan Normal University
2024
Fudan University
2024
Huashan Hospital
2024
Xi'an Jiaotong University
2024
Abstract Artificially improving traits of cultivated alfalfa ( Medicago sativa L.), one the most important forage crops, is challenging due to lack a reference genome and an efficient editing protocol, which mainly result from its autotetraploidy self-incompatibility. Here, we generate allele-aware chromosome-level assembly for consisting 32 allelic chromosomes by integrating high-fidelity single-molecule sequencing Hi-C data. We further establish CRISPR/Cas9-based protocol on basis this...
A fully disposable and integrated paper-based device by integrating nucleic acid extraction, amplification LFA could achieve testing.
Phylogeny and characteristics of ruminants Ruminants are a diverse group mammals that includes families containing well-known taxa such as deer, cows, goats. However, their evolutionary relationships have been contentious, the origins distinctive digestive systems headgear, including antlers horns (see Perspective by Ker Yang). To understand among ruminants, L. Chen et al. sequenced 44 species representing 6 performed phylogenetic analysis. From this analysis, they were able to resolve...
Abstract Inhibited immune response and low levels of delivery restrict starvation cancer therapy efficacy. Here, we report on the co-delivery glucose oxidase (GOx) indoleamine 2,3-dioxygenase (IDO) inhibitor 1-methyltryptophan using a metal-organic framework (MOF)-based nanoreactor, showing an amplified release for tumor starvation/oxidation immunotherapy. The nanosystem significantly overcomes biobarriers associated with penetration improves cargo bioavailability owing to weakly acidic...
A substantial amount of emerging research is indicating that the gut microbiota has a significant impact on human health. Alterations have clear consequences intestinal homeostasis, physiology, microbiome, immune system and host metabolic pathways. Diet composition plays an important role in control microbial populations and, thus, prevention, management treatment certain diseases such as cancer, diabetes. comprehensive analysis previously reported results revealed can be modulated by diet...
Paper has recently attracted increasing attention as a substrate for various biomedical applications. By modifying its physical and chemical properties, paper can be used an alternative to conventional cell culture substrates. Because it stacked into three-dimensional (3D) structure, which better mimic the in vivo microenvironment. shown great potential 3D platform developing normal diseased models. This gives precise control over extracellular matrix (ECM) composition well distribution...
New strategies for biofilm inhibition are becoming highly necessary because of the concerns to synthetic additives. As gallic acid (GA) is a hydrolysated natural product tannin in Chinese gall, this research studied effects GA on growth and formation bacteria (Escherichia coli [Gram-negative] Streptococcus mutans [Gram-positive]) under different conditions, such as nutrient levels, temperatures (25 37 °C) incubation times (24 48 h). The minimum antimicrobial concentration against two...
Poor cell uptake of drugs is one the major challenges for anticancer therapy. Moreover, inability to release adequate drug at tumor sites and inherent multidrug resistance (MDR) may further limit therapeutic effect. Herein, a delivery nanosystem with charge-reversal capability self-amplifiable pattern constructed by encapsulating β-lapachone in pH/ROS cascade-responsive polymeric prodrug micelle. The surface charge this micellar system would be converted from negative positive enhanced...
In nucleic acid testing (NAT), gold nanoparticle (AuNP)-based lateral flow assays (LFAs) have received significant attention due to their cost-effectiveness, rapidity, and the ability produce a simple colorimetric readout. However, poor sensitivity of AuNP-based LFAs limits its widespread applications. Even though various efforts been made improve assay sensitivity, most methods are inappropriate for integration into LFA sample-to-answer NAT at point-of-care (POC), usually complicated...
Paper-based devices have been broadly used for the point-of-care detection of dengue viral nucleic acids due to their simplicity, cost-effectiveness, and readily observable colorimetric readout. However, moderate sensitivity functionality limited applications. Despite above-mentioned advantages, paper substrates are lacking in ability control fluid flow, contrast flow enabled by polymer (e.g., agarose) with tunable pore size porosity. Herein, taking benefits from both materials, authors...
Hepatitis B virus (HBV) infection is a serious public health problem, which can be transmitted through various routes (e.g., blood donation) and cause hepatitis, liver cirrhosis cancer. Hence, it necessary to do diagnostic screening for high-risk HBV patients in these transmission routes. Nowadays, protein-based technologies have been used testing, however involve the issues of large sample volume, antibody instability poor specificity. Nucleic acid hybridization-based lateral flow assay...