A5039638614- Cancer-related molecular mechanisms research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Navier-Stokes equation solutions
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Supramolecular Chemistry and Complexes
- Geometric Analysis and Curvature Flows
- Wnt/β-catenin signaling in development and cancer
- Phonocardiography and Auscultation Techniques
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Molecular Sensors and Ion Detection
- Genetic factors in colorectal cancer
- Peptidase Inhibition and Analysis
- Music and Audio Processing
- Electrospun Nanofibers in Biomedical Applications
- Porphyrin and Phthalocyanine Chemistry
- MicroRNA in disease regulation
- Advances in Cucurbitaceae Research
- Wound Healing and Treatments
- Gas Dynamics and Kinetic Theory
Shanxi Medical University
2015-2024
Northwestern Polytechnical University
2018-2024
Shaanxi Provincial People's Hospital
2015-2024
Xi'an Jiaotong University
2013-2024
Shaanxi Provincial People's Hospital
2020-2023
Second Affiliated Hospital of Xi'an Jiaotong University
2021-2023
Chengdu University
2023
Capital Normal University
2023
Xizang Minzu University
2019-2022
Northwest University
2013-2022
With the increasing prevalence of drug-resistant bacterial infections and slow healing chronically infected wounds, development new antibacterial accelerated wound dressings has become a serious challenge. In order to solve this problem, we developed photo-crosslinked multifunctional adhesive anti-oxidant hemostatic hydrogel based on polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan (CSG-PEG), methacrylamide dopamine (DMA) zinc ion for disinfection...
The elastomers with the combination of high strength and toughness have always been intensively pursued due to their diverse applications. Biomedical applications frequently require biodegradability biocompatibility properties. It remains a great challenge prepare biodegradable extremely robust mechanical properties for in vivo use. In this report, we present polyurethane elastomer unprecedented application as hernia patches, which was obtained by solvent-free reaction polycaprolactone (PCL)...
Poor cell uptake of drugs is one the major challenges for anticancer therapy. Moreover, inability to release adequate drug at tumor sites and inherent multidrug resistance (MDR) may further limit therapeutic effect. Herein, a delivery nanosystem with charge-reversal capability self-amplifiable pattern constructed by encapsulating β-lapachone in pH/ROS cascade-responsive polymeric prodrug micelle. The surface charge this micellar system would be converted from negative positive enhanced...
The development of supramolecular hosts which can efficiently encapsulate photosensitizers to improve the photodynamic efficacy holds great promise for cancer therapy. Here, we report two perylene diimide-based metallacages that form stable host-guest complexes with planar conjugated molecules including polycyclic aromatic hydrocarbons and (hypocrellin A). Such complexation not only prevents aggregation in aqueous environments, but also offers fluorescence resonance energy transfer (FRET)...
The stomach is the main digestive organ in humans. Patients with gastric cancer often develop problems, which result poor nutrition. Nutritional status closely related to postoperative complications and quality of life (QoL) patients cancer. controlling nutritional (CONUT) score a novel tool evaluate patients. However, relationship CONUT complications, QoL, psychological has not been investigated. present follow-up study was conducted 106 who underwent radical gastrectomy our hospital...
Abstract Chirality in confined nanospaces has brought some new insights into chirality transfer, amplification, and chiroptical properties. However, switching, which is a common phenomenon biological systems, never been realized environments. Herein, we report type of hexagonal metallacages that shows good host–guest interactions with ethoxy pillar[5]arene pillar[6]arene, as confirmed by single‐crystal X‐ray analysis. Importantly, when chiral pillar[5]arene‐based molecular universal joint...
Bowel sounds (BSs), typically generated by the intestinal peristalses, are a significant physiological indicator of digestive system's health condition. In this study, wearable BS monitoring system is presented for long-term monitoring. The features sensor that can record BSs days long and transmit them wirelessly in real-time. With system, total 20 subjects' data under hospital environment were collected. Each subject recorded 24 hours. Through manual screening annotation, from every...
Abstract Background Solute carrier family 7 member 2 (SLC7A2), a cationic amino acid transporter, is lowly expressed in ovarian and hepatocellular cancers, which associated with their worse prognosis. However, its roles the prognosis, drug resistance immune infiltration non-small-cell lung cancer (NSCLC) are unclear. Methods We chose SLC7A2 from RNA-Seq of paclitaxel/cisplatin-resistant A549 cells, then bioinformatics, cell lines construction, RT-qPCR, CCK8 were performed to investigate...
Aberrant hypermethylation of Wnt antagonists has been observed in gastric cancer.A number studies have focused on the a single antagonist and its role regulating activation signaling.However, how interacted to regulate signaling pathway not reported.In present study, we systematically investigated methylation some genes (SFRP2, SFRP4, SFRP5, DKK1, DKK2, APC) their regulatory carcinogenesis.We found that aberrant promoter SFRP2, DKK2 was significantly increased cancer.Moreover, concurrent...
Naringin (Nar) is one of the natural glycosides extracted from pomelo and other citrus fruits. It has various pharmacological activities, including anti‑inflammatory, antioxidant, anti‑proliferative anti‑cancer. However, underlying mechanisms by which Nar regulates apoptosis autophagy in gastric cancer remain unclear. Thus, present study aimed to assess therapeutic effect mechanisms. SNU‑1 cell proliferation was determined using Cell Counting Kit‑8 assay. morphological changes were observed...
Background Postoperative abdominal adhesion is one of most common complications after operations. 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR) an adenosine 5’-monophosphate activated protein kinase (AMPK) pathway agonist that inhibits inflammation, reduces cell fibrosis and cellular reactive oxygen species (ROS) injury, promotes autophagy mitochondrial function. This study aimed to explore the mechanism AICAR in inhibiting formation. Materials methods Forty rats were randomly...
Abstract Atherosclerosis is one of the leading causes morbidity and mortality, mainly due to immune response triggered by recruitment monocytes/macrophages in artery wall. Accumulating evidence have shown that matrix stiffness oxidized low‐density lipoproteins (ox‐LDL) play important roles atherosclerosis through modulating cellular behaviors. However, whether there a synergistic effect for ox‐LDL on macrophages behavior has not been explored yet. In this study, we developed model system...
Objective: Costunolide (Cos) is a sesquiterpene lactone extracted from chicory. Although it possesses anti-tumor effects, the underlying molecular mechanism against gastric cancer cells remains unclear. This study aimed to explore effect and potential of Cos on cancer. Methods: The HGC-27 SNU-1 proliferation was detected by CCK-8 clone formation assay. changes in cell apoptosis were determined using Hoechst 33258 tunel staining. morphology autophagy analyzed autophagosomes with electron...
<p style='text-indent:20px;'>In this paper, we present sharp decay estimates for small data solutions to the following two systems: Vlasov-Poisson (V-P) system in dimension 3 or higher and Vlasov-Yukawa (V-Y) 2 higher. We rely on a modification of vector field method transport equation as developed by Smulevici 2016 system. Using Green's function particular estimate bilinear terms, improve Smulevici's result removing requirement some <inline-formula><tex-math...
Acquired resistance to 5-fluorouracil (5-FU) frequently occurs in patients with hepatocellular carcinoma (HCC), the underlying molecular mechanisms of which are poorly understood. The aim this study was identify candidate genes and associated signalling pathways that may play a role developing drug following repeated 5-FU treatments. In work, we established 5-FU-resistant cells (HepG2/5-FU) using stepwise increasing concentrations parental HepG2 cells. Using transcriptome sequencing, found...
Colorectal cancer (CRC) is a common malignant tumor that influenced by an interaction between genetic and environmental factors. Currently, the inherited factors of CRC are unclear. Our study selected 19 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with in Han population. In this Chinese case–control study, we genotyped 203 cases 296 controls using Sequenom MassARRAY technology analyzed their associations χ2 tests, SNPStats software, SHEsis...
Ferroptosis is associated with the development of many cancers; molecular features colorectal carcinoma (CRC) based on ferroptosis-related genes (FRGs) remain unknown. Herein, we aimed to identify ferroptosis-associated subtypes CRC expression profiles FRGs.To explore CRC, gene data and clinical information 682 patients were extracted from The Cancer Genome Atlas Gene Expression Omnibus databases. We performed consensus clustering robust clusters patients. Then distribution in terms...
Urea injection has been used in hemangioma treatment as sclerotherapy. It shrinks vascular endothelial cells and induces degeneration, necrosis, fibrosis. However, this still disadvantages, such lacking targeting difficulty controlling the urea dosage. Thus, we designed a immunoliposome to improve efficiency of treatment.The liposome was prepared by reverse phase evaporation. Furthermore, generated coupling with growth factor receptor (VEGFR) monoclonal antibody using glutaraldehyde...
The Au( i )–NHC complex 1 with strong electron-withdrawing nitro groups exhibited superior peroxidase-like activity, which catalyzed TMB + H 2 O system is designed for sensitive detection of GSH a low limit 0.14 μM.