A5084707099- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- Drug Transport and Resistance Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Cancer, Lipids, and Metabolism
- 14-3-3 protein interactions
- Flavonoids in Medical Research
- Childhood Cancer Survivors' Quality of Life
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
Shaanxi Provincial People's Hospital
2020-2024
Shanxi Medical University
2020-2024
Northwestern Polytechnical University
2021-2022
Shaanxi Provincial People's Hospital
2021-2022
Xizang Minzu University
2021
Huazhong University of Science and Technology
2014
Union Hospital
2014
The involvement of M2-like tumor-associated macrophages (TAMs) in the advancement and treatment cancer has been widely documented. This study aimed to develop a new signature associated with TAMs predict prognosis response individuals diagnosed breast (BC). Weighted gene co-expression network analysis (WGCNA) was used identity for TAM-related modular genes. subtype identified using unsupervised clustering. WGCNA 722 TAM genes, 204 which were recurrence-free survival (RFS). Patients cluster 1...
This study intends to conquer the mystery of microRNA-16-5p/erythropoietin-producing hepatocellular A1/nuclear factor-κB signaling (miR-16-5p/EPHA1/NF-κB signaling) in breast cancer.Expression miR-16-5p, EPHA1 and NF-κB signaling-related proteins were detected. Gene overexpression or silencing was used examine biological roles bone marrow mesenchymal stem cells (BMSCs)-derived exo-miR-16-5p cancer. The effect on tumorigenesis cancer confirmed by xenograft nude mouse model.Low miR-16-5p high...
Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an important pathway in cancers. Long non-coding RNAs (lncRNAs) are key regulators breast cancer development. Nevertheless, few studies reporting the effect lncRNAs necroptosis processes and role necroptosis-related (NRLs). The present study aimed to construct prognostic model based on NRLs cancer. were identified by combining expression profiling data from Cancer Genome Atlas (TCGA) with genes....
Ferroptosis is associated with the development of many cancers; molecular features colorectal carcinoma (CRC) based on ferroptosis-related genes (FRGs) remain unknown. Herein, we aimed to identify ferroptosis-associated subtypes CRC expression profiles FRGs.To explore CRC, gene data and clinical information 682 patients were extracted from The Cancer Genome Atlas Gene Expression Omnibus databases. We performed consensus clustering robust clusters patients. Then distribution in terms...
Abstract Gastric cancer (GC) is a highly heterogeneous malignancy, characterized by high mortality and poor prognosis. Ferroptosis newly defined nonapoptotic programmed cell death mechanism that has been implicated in the development of various pathological conditions. We aimed to identify ferroptosis‐related long noncoding RNA (lncRNAs) might be used predict GC The data were obtained from Cancer Genome Atlas (TCGA) Gene Expression Omnibus database. Two subtypes, C1 C2, identified, which had...
Cumulative studies have suggested that dysregulation of m6A regulators and immunity is highly linked to the prognosis patients with cancer. However, potential contribution modification patterns tumor microenvironment (TME) therapeutic efficacy immunotherapy for colorectal cancer (CRC) remain elusive. A comprehensive analysis profiles 458 CRC was performed by clustering 21 genes encoding methylation linking pattern TME characteristics. Using principal component (PCA), a risk model constructed...
Biphenotypic acute leukemia (BAL) is an uncommon type of cancer, which accounts for <5% all adult ALs. Based upon a previously described scoring system, the European Group Immunological Classification Leukemias (EGIL) proposed set diagnostic criteria BAL. This system based number and degree specificity several markers myeloid or T/B-lymphoid blasts. The present study describes case T-cell lymphoblastic (T-ALL) with Burkitt-like cytology, according to French-American-British classification,...
Noncoding ribonucleic acids (ncRNAs) are involved in various functions the formation and progression of different tumors. However, association between N6-methyladenosine-related ncRNAs (m6A-related ncRNAs) gastric cancer (GC) prognosis remains elusive. As such, this research was aimed at identifying m6A-related (lncRNAs miRNAs) GC developing prognostic models relevant potential biomarkers regulated by m6A. In study, m6A2Target database, Starbase The Cancer Genome Atlas (TCGA) were used to...
Endometrial cancer (UCEC) is very common in gynecological diseases and ranks second the death cause of developed countries. The connection between overall survival UCEC patients immune invasion tumor microenvironment positive. PARVG gene has not been given notice cancer, its mechanism unknown. research utilized TCGA data to test function UCEC. manifestation was studied by GEPIA. By assessing module, authors learned impact on people with then obtained information from TCGA. This study uses...
Abstract Background : Ferroptosis is an iron-dependent form of programmed cell death, involves in the development many cancers. However, systematic analysis ferroptosis related-genes colorectal carcinoma (CRC) remains to be clarified. We herein analyzed public databases identify molecular features CRC by a classification based on gene expression profile ferroptosis-related genes. Methods: collected data and clinical information from The Cancer Atlas Gene Expression Omnibus explore...
Abstract Background: Breast invasive carcinoma (BRCA) is the primary cause of cancer-associated mortality worldwide. Platelet endothelial cell adhesion molecule 1 (PECAM-1) has been implicated in a number important biological processes. However, interrelation between PECAM-1 gene expression, tumor immunity, and prognosis patients with BRCA unclear. The current study aimed to analyze expression clinical significance breast cancer correlation immune infiltrations. Methods: differential...