A5005343652- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Multiple Myeloma Research and Treatments
- Renal Diseases and Glomerulopathies
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chronic Kidney Disease and Diabetes
- RNA Research and Splicing
- Retinoids in leukemia and cellular processes
- Kruppel-like factors research
- Systemic Lupus Erythematosus Research
- Toxin Mechanisms and Immunotoxins
- Glioma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Protein Degradation and Inhibitors
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Tumors and Oncological Cases
Henan Agricultural University
2024-2025
Shanghai University of Sport
2025
Second Military Medical University
2024
Lanzhou University
2022-2024
Lanzhou University Second Hospital
2022-2024
China Agricultural University
2024
Weifang Medical University
2020-2024
Gansu University of Traditional Chinese Medicine
2023
Shanxi Medical University
2022
Shaanxi Provincial People's Hospital
2022
Introduction The microbial genome-wide association studies (mbGWAS) have highlighted significant host-microbiome interactions based on microbiome heritability. However, establishing causal relationships between particular microbiota and multiple myeloma (MM) remains challenging due to limited sample sizes. Methods Gut data from a GWAS with 18,340 participants MM summary statistics 456,348 individuals. inverse variance-weighted (IVW) method was used as the main bidirectional Mendelian...
Abstract Increasing lines of evidence indicate the role long non-coding RNAs (LncRNAs) in gene regulation and tumor development. Hence, it is important to elucidate mechanisms LncRNAs underlying proliferation, metastasis, invasion lung adenocarcinoma (LUAD). We employed microarrays screen LUAD tissues with without lymph node metastasis revealed their effects on LUAD. Among them, Linc00426 was selected for further exploration its expression, biological significance, molecular mechanisms....
Schematic diagram of the miR-4732-5p/XPR1 axis regulatory mechanism in LUAD.
The present study is aimed at exploring the specific expression of miR-193a-3p and mechanism underlying miR-193a-3p-mediated mesenchymal transition (MT), invasion, migration in glioma.The gene profile datasets GSE39486 GSE25676 were downloaded from National Center for Biotechnology (NCBI). Data regarding survival curves derived Chinese Glioma Genome Atlas (CGGA). Online websites including miRWalk, DIANA, starbase employed to predict target genes miR-193a-3p. Gene Ontology (GO) Kyoto...
In the pathogenesis of myeloproliferative neoplasms (MPN), inflammation plays an important role. However, it is unclear whether there a causal link between and MPNs. We used bidirectional, two-sample Mendelian randomization (MR) approach to investigate relationship systemic inflammatory cytokines neoplasms.
Ferroptosis is associated with the development of many cancers; molecular features colorectal carcinoma (CRC) based on ferroptosis-related genes (FRGs) remain unknown. Herein, we aimed to identify ferroptosis-associated subtypes CRC expression profiles FRGs.To explore CRC, gene data and clinical information 682 patients were extracted from The Cancer Genome Atlas Gene Expression Omnibus databases. We performed consensus clustering robust clusters patients. Then distribution in terms...
The aim of our study was to identify key biomarkers glomeruli in focal glomerulosclerosis (FSGS) and analyze their relationship with the infiltration immune cells.The expression profiles (GSE108109 GSE200828) were obtained from GEO database. differentially expressed genes (DEGs) filtered analyzed by gene set enrichment analysis (GSEA). MCODE module constructed. Weighted coexpression network (WGCNA) performed obtain core modules. Least absolute shrinkage selection operator (LASSO) regression...
Abstract Gastric cancer (GC) is a highly heterogeneous malignancy, characterized by high mortality and poor prognosis. Ferroptosis newly defined nonapoptotic programmed cell death mechanism that has been implicated in the development of various pathological conditions. We aimed to identify ferroptosis‐related long noncoding RNA (lncRNAs) might be used predict GC The data were obtained from Cancer Genome Atlas (TCGA) Gene Expression Omnibus database. Two subtypes, C1 C2, identified, which had...
Genomic profiling of cerebrospinal fluid (CSF) can be used to detect actionable mutations and guide clinical treatment non-small cell lung cancer (NSCLC) patients with central nervous system (CNS) metastases. Examining the performance CSF samples in real-world settings confirm potential genotyping for guiding therapy practice. We included 1,396 from 970 NSCLC CNS metastases settings. All underwent targeted next-generation sequencing 1,021 cancer-relevant genes. In total, 100 77 who had...
Long non-coding RNAs (LncRNAs) has been confirmed to play a crucial role in the development and progression of various cancer types. Here we evaluated expression profiles LncRNAs Lung adenocarcinoma (LUAD) tissues identified novel LncRNA, termed LncRNA-AC009948.5. However, potential molecular mechanisms this LncRNA LUAD carcinogenesis is unknown. Regarding public databases based on integrating bioinformatics analyses, determined whether LncRNA-AC009948.5 exerts its oncogenic functions via...
The introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has transformed the outcome acute promyelocytic leukemia (APL) from a uniformly fatal disease to one most curable human malignancies in recent decades. However, early mortality caused by coagulopathy, infection, multi-organ failure, differentiation syndrome (DS) during onset induction treatment remains major issue APL, especially elderly patients who may suffer higher treatment-related due vulnerability toxicities....
To investigate the antitumor effect of SGI-1776 on human ovarian cancer HO-8910 cells and its molecular mechanism.HO-8910 were cultured in vitro, proliferation inhibitory effects SGI- 1776 determined by MTT assay colony formation assay. The distribution cell cycle phase was observed flow cytometry with propidium iodide (PI) staining. inhibition rate migration invasion valued transwell Multiple techniques, such as ELISA, Western blot, siRNA cDNA transfection used to explore mechanism.SGI-1776...
Zygotic epigenetic reprogramming is the major initial event in embryo development to acquire a totipotent potential. However, patterns of modifications bovine zygote were not well clarified, especially first cell cycle somatic nuclear transfer (SCNT) embryos. This study was conducted examine DNA methylation (5-methylcytosine [5mc] and 5-hydroxymethylcytosine [5hmc]) histone H3 lysine 9 (H3K9m2 H3K9m3) vitro fertilization (IVF) SCNT In zygotic development, 5mc paternal pronucleus (pPN)...
Multiple myeloma (MM) is one of the most common tumors hematological system and remains incurable. Recent studies have shown that long noncoding RNA NORAD a potential oncogene in variety tumors. However, general biological role clinical value MM unknown. In this study, we measured expression bone marrow 60 newly diagnosed MM, 30 post treatment 17 healthy donors by real-time quantitative polymerase chain reaction (qPCR). The gene was knockdown lentiviral transfection cell lines, effects on...
Cumulative studies have suggested that dysregulation of m6A regulators and immunity is highly linked to the prognosis patients with cancer. However, potential contribution modification patterns tumor microenvironment (TME) therapeutic efficacy immunotherapy for colorectal cancer (CRC) remain elusive. A comprehensive analysis profiles 458 CRC was performed by clustering 21 genes encoding methylation linking pattern TME characteristics. Using principal component (PCA), a risk model constructed...
To investigate the effect of miR-204 on invasion and metastasis breast cancer by targeted regulation HNRNPA2B1.The bioinformatics database was used to obtain data expressions in patients survival rate patients. RT-qPCR detect expression cell lines. The vector GV369-miR-204 overexpress MDA-MB-231 cells. Transwell assay performed migration ability key genes (hub genes) were determined method. A dual luciferase analyze targeting relationship between HNRNPA2B1. HNRNPA2B1 cells after...
To investigate the effects of miR-300 and PTTG1 on osteosarcoma invasion metastasis explore molecular mechanism metastasis.Western blot was used to detect expression in human osteoblasts hFOB1.19 cell MG63 transfection efficiency cells transfected with PTTG1-knockdown plasmid; Transwell assay CCK8 detected knockdown overexpression proliferation MG63. On-line prediction screening microRNAs (miRNAs) complementary binding conducted. qRT-PCR performed examine cells, Western blotting after a miR-...