A5100763045- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- RNA modifications and cancer
- Animal Nutrition and Physiology
- RNA Research and Splicing
- Gut microbiota and health
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Animal Behavior and Welfare Studies
- Effects of Environmental Stressors on Livestock
- Genetic diversity and population structure
- Meat and Animal Product Quality
- Inflammatory Bowel Disease
- Molecular Biology Techniques and Applications
- Reproductive Biology and Fertility
- Dermatological and Skeletal Disorders
- Reproductive System and Pregnancy
- Aquatic Ecosystems and Phytoplankton Dynamics
- Ginseng Biological Effects and Applications
- Probiotics and Fermented Foods
- Sperm and Testicular Function
- Fish Ecology and Management Studies
- CRISPR and Genetic Engineering
- Protease and Inhibitor Mechanisms
Henan Agricultural University
2016-2025
Zhengzhou Railway Vocational & Technical College
2025
Linyi University
2007-2024
Sun Yat-sen Memorial Hospital
2021-2024
Sun Yat-sen University
2020-2024
Henan Provincial People's Hospital
2016-2024
Henan University
2017-2024
Zhengzhou University
2018-2024
Qingdao University
2023-2024
AstraZeneca (United States)
2024
Modern breeding and artificial selection play critical roles in pig domestication shape the genetic variation of different breeds. China has many indigenous breeds with various characteristics morphology production performance that differ from those foreign commercial However, signatures on genes implying for economic traits between Chinese pigs have been poorly understood.We identified footprints positive at whole genome level, comprising 44,652 SNPs genotyped six breeds, one developed...
Vero cells are considered as the most widely accepted continuous cell line by regulatory authorities (such WHO) for manufacture of viral vaccines human use. The growth is anchorage-dependent. Scale-up and manufacturing in adherent cultures labor intensive complicated. Adaptation to grow suspension will simplify subcultivation process scale-up significantly, therefore reduce production cost. Here we report on a successful adaptation serum-free animal component-free medium (IHM03) developed...
Heavy metal pollution in the environment is mostly manifested as a multi-elemental compound pollution. The effect of long-term exposure to heavy on gut microbes insects has remained unknown. For current work, population Eucriotettix oculatus living mining areas around Diaojiang River with history hundreds years pollution, was selected along similar species non-mining conduct comparative study their microbes. microbial communities were analyzed using 16S rRNA amplicon sequencing. results...
Abstract Microalgal energy storage compounds (carbohydrates, lipids, etc.) can serve as renewable feedstocks for biofuels and biobased chemicals. Traditional methods of inducing the accumulation in microalgae, such abiotic stress (high light intensity, high salinity, nutrient limitation, heavy metals, etc.), affect growth microalgae limit their efficient materials. Plant hormones are a class small molecular substances that act chemical messengers to coordinate plant cell activities regulate...
Twenty 35-wk-old chickens, including 10 Single Comb White Leghorn (SCWL) and Rhode Island Red (RIR) hens, were used to examine the effects of egg yolk weights on antibody (IgY) production in two strains chickens immunized with BSA. The SCWL had a greater (P < 0.01) percentage hen-day than did RIR chickens. However, anti-BSA activities determined by ELISA serum similar > 0.05) between Similarities hens also observed protein total IgY contents (expressed as wet weight yolk) BSA-specific IgY....
Abstract Clinical pregnancies increasingly end in recurrent miscarriage (RM) during the first trimester, with genetic factors shouldering main responsibility. MicroRNAs (miRNAs) regulate gene expression a wide array of important biological processes. We examined potential role dysregulated miRNAs RM pathogenesis and trophoblast development as an approach to elucidate molecular mechanism behind RM. miRNA profiles from clinical specimens induced abortion (IA) were compared, several found be...
To investigate the underlying mechanism of lncRNA TUG1 in pancreatic ductal adenocarcinoma (PDAC).The expression was defined by qRT-PCR. The apoptotic cells were detected flow cytometry assay. cell migration and invasion measured scratch assay Transwell level ERK pathway using Western blot.Compared with normal tissues cells, up-regulated cancer tissue cells. Meanwhile, knockdown could promote PDAC apoptosis inhibit viability, invasion. In addition, overexpression enhanced gemcitabine...
The Yi River, the second longest river in Shandong Province, China, flows through Linyi City and is fed by three tributary rivers, Beng Liuqing Su River northeastern part of city. In this study, we determined concentrations five heavy metals (Cr, Ni, Cu, Zn, Pb) water, sediment, aquatic macrophyte samples collected from junction four rivers evaluated potential ecological risk metal pollution. Most water were low with quality index (WQI) below 1, suggesting sediments showed concentrations, a...
A method based on a QuEChERS (quick, easy, cheap, effective, rugged, safe) sample preparation and gas chromatography with mass spectrometric detection by selected ion monitoring (GC/MS-SIM) was developed for simultaneous determination of 77 pesticide residues in wine. An extraction 10 ml acetonitrile followed liquid-liquid partition formed the addition 4 g MgSO(4) 3 NaCl applied preparation. The clean-up carried out applying dispersive solid-phase 150 mg as well 50 primary secondary amine...
Summary Growth‐related traits are important economic in the pig industry that directly influence pork production efficiency. To detect quantitative trait loci and candidate genes affecting growth traits, genome‐wide association studies were performed for backfat thickness (BF) loin muscle depth (LMD) 370 Chuying‐black pigs using Illumina PorcineSNP50 BeadChip array. We totally identified 14 BF‐associated SNPs, which included 11 SNPs ( P < 1.39E‐06) 3 chromosome‐wide suggestive 2.79E‐05)...
Abstract Cytokinin (CTK) has an important regulatory effect on plant morphology, physiology, and yield, is one of the main factors regulating nitrogen absorption, transport, metabolism. This paper reviews research progress in transport metabolism, cytokinin synthesis, signal transduction, etc., focusing physiological mechanisms by which CTK collaborate to regulate root–shoot relationship its impact agronomic traits crops. The synthesis trans‐zeatin ( t Z) riboside ZR) generally regulated...
In the realm of industrial quality control, visual inspection plays a pivotal role in ensuring product precision and consistency. Moreover, it enables non-contact inspection, preventing products from potential damage, timely monitoring capabilities facilitate quick decision making. However, traditional methods, such as manual using feeler gauges, are time-consuming, labor-intensive, prone to human error. To address these limitations, this study proposes deep learning-based system for...
To study the key genes that influence body size of local pig breeds in China. Genome-wide SNP chip data from a total 129 pigs eight breeds, consisting four large (MZ, HT, ST, RC) and small (XI, BX, WZ, DN) were analyzed. Principal Component Analysis (PCA) was employed to assess genetic clustering breeds. Fst XP-CLR used detect selective signals between ans groups. The PCA results indicated clear dispersion distribution among identified 142 overlapping regions within 500 kb up & down stream...
Matrix metalloproteinases (MMPs) and monocyte chemoattractant protein-1 (MCP-1, CCL2) are known to be upregulated in many tumors. Their roles tumor invasion metastasis being uncovered. How they related each other involved progression remains determined. Earlier it was reported that I-BOP-initiated activation of thromboxane A2 receptor (TP) induced the release MMP-1, MMP-3, MMP-9 from lung cancer A549 cells overexpressing TPα (A549-TPα). Herein found but not MMP-3 or MMP-9, expression MCP-1...
Litter size has increased and farrowing duration also prolonged in recent years. The aim of this study was to analyze the effect litter parity on (FAR) estimate possibility selecting a short duration. We recorded 32,200 parturitions 8420 Landrace × Yorkshire sows, determined duration, size, parity, gestation length. Results showed that total number born (TNB) obeyed cubic (p = 0.0004, p 0.004) relationship while alive (NBA) dead (NBD) linear 0.0239, 0.0035) with FAR. Gestation length 0.02)...
Mesenchymal stem cells (MSCs) possess powerful immunomodulatory ability. This study aimed to assess the efficacy and safety of human umbilical cord-derived mesenchymal (UMSCs) in patients with ulcerative colitis (UC) explore potential mechanisms. prospective, self-controlled clinical was conducted at Henan Provincial People's Hospital. Patients moderate-to-severe active UC, unresponsive traditional drugs were continuously enrolled from September 2018 March 2023. UMSCs administered...