A5112256310- Extracellular vesicles in disease
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- HER2/EGFR in Cancer Research
- Protein Hydrolysis and Bioactive Peptides
- Cognitive Abilities and Testing
- Dementia and Cognitive Impairment Research
- Nanoparticles: synthesis and applications
- Trace Elements in Health
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Reproductive Biology and Fertility
- Hormonal and reproductive studies
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Sexual function and dysfunction studies
- Mechanisms of cancer metastasis
- Ovarian function and disorders
- Liver Disease Diagnosis and Treatment
- Reproductive System and Pregnancy
Southern Medical University
2025
Henan University of Science and Technology
2024
Second Military Medical University
2020-2022
Chinese People's Liberation Army
2020
Guangdong Pharmaceutical University
2020
South China University of Technology
2020
Air Force Medical University
2013-2017
Xijing Hospital
2014
Abstract Metallic nanoparticles (NPs) have potential applications in industry and medicine, but they also the to cause many chronic pulmonary diseases. Mechanisms for their cytotoxicity, glucose energy metabolism responses need be fully explained lung epithelial cells after treatment with metallic nanoparticles. In our study, two different (Fe 2 O 3 ZnO) cell‐based assays (BEAS‐2B A549 cell lines) were used. Our findings demonstrate that ZnO nanoparticles, not Fe induce cycle arrest,...
Tamoxifen, an endocrine therapy drug used to treat breast cancer, is designed interrupt estrogen signaling by blocking the receptor (ER). However, many ER-positive patients are low reactive or resistant tamoxifen. Metformin a widely anti-diabetic with noteworthy anti-cancer effects. We investigated whether metformin has additive effects tamoxifen in cancer therapy. The efficacy of alone and combination against was analyzed cell survival, DNA replication activity, plate colony formation,...
Abstract Docetaxel is commonly used as an effective chemotherapeutic agent in breast cancer treatment, but the underlying mechanisms of drug resistance are not fully understood. The purpose this study was to investigate possible role miR-129-3p cell docetaxel. MiR-129 and inhibitor were transfected into cells their effects on chemoresistance function evaluated by apoptosis, proliferation cycle assays. We found that up-regulated MDA-MB-231/Doc cells, concurrent with CP110 down-regulation,...
ABSTRACT HER2‐overexpressing breast cancers often show hyperactivation of the HER2/AKT/mTOR signaling pathway. Lapatinib is an oral dual tyrosine kinase inhibitor (TKI) that targets both EGFR and HER2 to inhibit proliferation cancer cells. However, it obscure whether how lapatinib could induce autophagy in cells, important cell response with drug treatment. In this study, we investigated apoptosis cells BT474 AU565 treated lapatinib, further examined their relationship. inhibited rate DNA...
Abstract Our previous study revealed that red kidney bean polysaccharides (RKB) exhibit a pronounced hypoglycemic effect on type 2 diabetic rats, while simultaneously exerting significant ameliorative impact hepatic damage in these animals. However, the precise mechanism underlying effects of RKB diabetes and liver metabolism remains unproven. In this study, we utilized mouse model induced by high‐fat diet combined with streptozotocin to investigate RKB. We administered intervention...
The analysis of cognitive trajectories is relatively underexplored in China. Furthermore, most previous studies examining the association between function and mortality have been limited to cross-sectional perspectives. This study aims identify distinct corresponding influencing factors investigate impact these on all-cause Chinese older adults. A total 6232 subjects aged 65 years above were drawn from Longitudinal Healthy Longevity Survey. Growth mixture models utilized different...
This study intends to conquer the mystery of microRNA-16-5p/erythropoietin-producing hepatocellular A1/nuclear factor-κB signaling (miR-16-5p/EPHA1/NF-κB signaling) in breast cancer.Expression miR-16-5p, EPHA1 and NF-κB signaling-related proteins were detected. Gene overexpression or silencing was used examine biological roles bone marrow mesenchymal stem cells (BMSCs)-derived exo-miR-16-5p cancer. The effect on tumorigenesis cancer confirmed by xenograft nude mouse model.Low miR-16-5p high...
Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an important pathway in cancers. Long non-coding RNAs (lncRNAs) are key regulators breast cancer development. Nevertheless, few studies reporting the effect lncRNAs necroptosis processes and role necroptosis-related (NRLs). The present study aimed to construct prognostic model based on NRLs cancer. were identified by combining expression profiling data from Cancer Genome Atlas (TCGA) with genes....
Chemo-resistance presents a difficult challenge for the treatment of breast cancer. Our previous study showed that N-Myc downstream-regulated gene 2 (NDRG2) is involved in p53-mediated apoptosis induced by chemotherapy, through mechanism has so far remained obscure. Here, we explored role NDRG2 chemo-resistance with focus on Adriamycin (ADR) and found expression decreased ADR resistance cancer cells. Interestingly, can promote sensitivity inhibiting proliferation, enhancing cellular damage...