A5084627119- Particle accelerators and beam dynamics
- Superconducting Materials and Applications
- Particle Accelerators and Free-Electron Lasers
- Magnetic confinement fusion research
- Metamaterials and Metasurfaces Applications
- Advanced Antenna and Metasurface Technologies
- Plasmonic and Surface Plasmon Research
- Nuclear Physics and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Plasma Diagnostics and Applications
- Antenna Design and Analysis
- Near-Field Optical Microscopy
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Acute Ischemic Stroke Management
- Organic and Molecular Conductors Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Photonic and Optical Devices
- Orbital Angular Momentum in Optics
- Cancer-related Molecular Pathways
- Tea Polyphenols and Effects
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Nuclear reactor physics and engineering
- Atomic and Molecular Physics
China Agricultural University
2021-2025
Wenzhou Medical University
2025
Sichuan University
2023-2025
State Key Laboratory of Hydraulics and Mountain River Engineering
2023-2025
Lishui City People's Hospital
2025
Zhejiang University
2025
Cell Technology (China)
2025
Xi'an Jiaotong University
2002-2024
National University of Singapore
2024
Tianjin University
2024
The D-type cyclin-dependent kinases CDK4 and CDK6 are complexed with many small cellular proteins (p14, p15, p16, p18, p20). We have isolated cDNA sequences corresponding to the MTS2 genomic fragment that encodes CDK4- CDK6-associated p14 protein. By use of a yeast interaction screen search for CDK6-interacting proteins, we also identified an 18-kD human protein, is homolog cyclin D-CDK4 inhibitors p16 (INK4A/MTS1) (MTS2/INK4B). Both in vivo vitro, p18 interacts strongly CDK6, weakly CDK4,...
Abstract Recently, a concept of digital metamaterials has been proposed to manipulate field distribution through proper spatial mixtures metamaterial bits. Here, we present design 2-bit digitally-controlled coding metasurface that can effectively modulate the scattered electromagnetic wave and realize different far-field beams. Each meta-atom this integrates two pin diodes, by tuning their operating states, four phase responses 0, π/2, π, 3π/2, corresponding basic elements “00”, “01”, “10”,...
Abstract Dispersion engineering of metamaterials is critical yet not fully released in applications where broadband and multispectral responses are desirable. Here we propose a strategy to circumvent the bandwidth limitation by implementing two-dimensional dispersion meta-atoms. Lorentzian resonances exploited as building blocks both dimensions dedicatedly designed meta-atoms construct expected dispersion. We validated this designing fabricating an anisotropic metamirror, which can...
Considerable attentions have been focused on the realization of carpet cloaks in past decade. Most current can perform only one electromagnetic (EM) shape for concealing inside objects, and dynamical control arbitrary EM virtual shapes remains a significant challenge. Here, desirable method is proposed to construct reconfigurable cloak using tunable metasurface technology. By controlling active elements loaded metasurface, surface phase distribution be dynamically changed make generate...
Abstract A flexible and transparent microwave–infrared bistealth structure is proposed to avoid composite detection in the microwave infrared bands. By combining intrinsic material properties with proper design, metamaterial can simultaneously achieve high absorption band, low emission optical transparency. The exhibits wide‐angle (40°), broadband (7.7–18 GHz), high‐efficiency (>90%) absorption. Furthermore, by using cover a metallic column, 10 dB reduction radar cross section at 7.5–18...
Highly crystalline films of a silver-based coordination polymer, [Ag5(C6S6)]n (Ag-BHT, BHT = benzenehexathiol), have been prepared. The structure Ag-BHT, solved by combining rotation electron diffraction and powder X-ray techniques, indicates that it has lamellar with alternatively stacked two-dimensional Ag–S networks layers composed one-dimensional metal-dithiolene polymers. In addition, the polycrystalline Ag-BHT film shows high electrical conductivity up to 250 S·cm–1 at 300 K....
In this communication, we propose a method to achieve high-efficiency transmission and wideband scattering reduction at two distinctive frequency bands by combining frequency-selective surface (FSS) electromagnetic bandgap (EBG) surface. Such FSS-EBG is composed of two-layered metallic patterns. The bottom FSS layer works as filter for allowing in-band signal pass reflecting out-of-band signal, while the top EBG adopts 0 π reflection phase cells with chessboard distribution reduce backward...
Recently, considerable attention has been focused on orbital angular momentum (OAM) vortex wave, owing to its prospect of increasing communication capacity. Here, a single-layer metasurface is proposed realize beams with different OAM modes and polarizations carried at two distinctive bands. Both the resonant geometric (Pancharatnam-Berry) phase cells are adopted construct this for generating desired profile, each type modulation cell can independently control beam frequencies. When...
Due to the rapid growth of web conferences, remote screen sharing, and online games, content has become an important type internet media information over 90% interactions are based. Meanwhile, as main component in content, textual averagely takes up 40% whole image on various commonly used datasets. However, it is difficult compress by using traditional coding schemes HEVC, which assumes strong spatial temporal correlations within image/video. State-of-the-art (SCC) standard HEVC-SCC still...
Abstract Cascaded metasurfaces can exhibit powerful dynamic light manipulation by mechanically tuning the far‐field interactions in layers. However, most current designs, are separated gaps smaller than a wavelength to form total phase profile, representing direct accumulation of profiles each layer. Such small gap sizes may not only conflict with conditions but also pose great difficulties for practical implementations. To overcome this limitation, design paradigm taking advantage...
NADPH oxidase 4 (NOX4) may play a critical role for inducing oxidative stress and inflammation after spontaneous intracerebral hemorrhage (sICH). This study was performed to assess associations of serum NOX4 levels with sICH severity, early neurological deterioration (END) outcomes. In this prospective cohort study, 161 patients controls were collected quantifying levels. END defined as decrease ≥2 points in Glasgow coma scale (GCS) score within 24 hours admission. Poor outcome referred...
Abstract Ultrathin metasurfaces pave an encouraging way for invisibility carpet cloaks on account of their excellent electromagnetic wavefront manipulation. However, the current metasurface‐based operate at only one wavelength and are limited by narrow bandwidth. Here, a dual‐wavelength cloak using two‐layer metasurface microwave frequencies is proposed. By individual design phase compensation each layer metasurface, proposed can restore scattering behaviors flat conducting plane different...
In this article, a dual-band wide-angle metamaterial perfect absorber is proposed to achieve absorption at the wavelength where laser radar operates. It composed of gold ring array and Helmholtz resonance cavity spaced by Si dielectric layer. Numerical simulation results reveal that designed displays two peaks target 10.6 μm 1.064 with large frequency ratio near-unity absorptivity under normal incidence. The absorbing property polarization-insensitive feature are also demonstrated. Localized...
As the most abundant marine carotenoid extracted from seaweeds, fucoxanthin (FUC) is considered to have excellent neuroprotective activity. However, target of FUC for its properties remains largely unclear. Oxidative stress one initiating factors causing neuronal cell loss and necrosis, it also an important inducement Parkinson’s disease (PD). In present study, effect was assessed using a 6‐hydroxydopamine‐ (6‐OHDA‐) induced neurotoxicity model. suppressed 6‐OHDA‐induced accumulation...
Abstract Insulin sensitivity progressively declines with age. Currently, the mechanism underlying age-associated insulin resistance remains unknown. Here, we identify membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) as a central regulator of during ageing. Ageing promotes MMP14 activation in insulin-sensitive tissues, which cleaves Receptor to suppress signaling. MT1-MMP inhibition restores expression, improving aged mice. The cleavage by also contributes obesity-induced and...
Activation of the mitogen-activated protein kinase cascade is a critical event in mitogenic growth factor signal transduction. Mitogen-activated directly activated by dual specific kinase, MEK, which itself serine phosphorylation. The c-Raf has been implicated mediating transduction from receptors to MEK activation. Recently, B-Raf was shown be capable phosphorylating and activating as result stimulation. In this report, we used yeast two-hybrid screening isolate interacting proteins. All...
Cyclin-dependent kinases 4 and 6 are complexed with many small cellular proteins in vivo. We have isolated cDNA sequences, INK4d, encoding a 19-kDa protein that is associated CDK6 several hematopoietic cell lines. p19 shares equal similarity common ancestor other identified inhibitors of the p16/INK4 family. interacts inhibits activity both CDK4 exhibits no detectable interaction known CDKs. present nuclei cytoplasm. The gene has been mapped to chromosome 19p13.2, level its mRNA expression...
Demyelination is a critical neurological disease, and there still lack of effective treatment methods. In the past two decades, stem cells have emerged as novel therapeutic effector for neural regeneration. However, owing to existence blood-brain barrier (BBB) complex microenvironment, targeted therapy faces multiple challenges. Targeted exosome carriers drug delivery may be considered promising method. Exosomes were isolated from mice cells. To develop targeting exosomes, we generated...
Germline or somatic loss-of-function mutations of fumarate hydratase (FH) predispose patients to an aggressive form renal cell carcinoma (RCC). Since other than tumor resection, there is no effective therapy for metastatic FH-deficient RCC, accurate method early diagnosis needed. Although MRI CT scans are offered, they cannot differentiate tumors from RCCs. Therefore, finding noninvasive plasma biomarkers suitable rapid diagnosis, screening and surveillance would improve clinical outcomes....
Tuberculosis is a severe contagious disease caused by Mycobacterium tuberculosis (Mtb). To develop new vaccines and medicine against TB, there an urgent need to provide insights into the mechanisms which Mtb induces tuberculosis. In this study, we found that secreted virulence factor MptpB significantly enhanced survival of H37Rv in macrophages. suppressed production iNOS, expression inflammatory factors IL-1β IL-6, as well apoptosis macrophage infected RAW264.7 cells. Mechanism...
Due to the strong capability control electromagnetic (EM) wave, metasurfaces have garnered considerable interest and brought in many intriguing EM functional devices. However, most of such devices can only work either transmitted or reflected mode, it is still very challenging achieve a simultaneous reflection transmission one device. Here, we present cascaded metasurface which integrates resonant geometrical phase cells, manipulate wave independently. By specific design distribution,...
3D well-crystallized metal-organic frameworks (MOFs), M-THBQ (M=Fe, Co, Mn, THBQ=tetrahydroxybenzoquinone), are synthesized and characterized. Their structures determined as cubic cell in the group of Pm 3‾ from powder X-ray diffraction data, their properties electronic, magnetic spectroscopic also investigated. They all semiconductors, Fe-THBQ exhibits air-stable n-type thermoelectric characteristic its Seebeck coefficient reaches -130 μV K-1 , electrical conductivity is 2.7×10-4 S cm-1 at...
Conductive coordination polymers (CPs) have potential in a wide range of applications because their inherent structural and functional diversity. Three electrically conductive CPs (Cux C6 S6 , x=3, 4 or 5.5) derived from the same organic linker (benzenehexathiol) metal node (copper(I)) were synthesized studied. Cux materials are organic-inorganic hybrid copper sulfides comprising π-π stacking structure cooper sulfur networks. Charge-transport pathways within network facilitate conductivity...
The lack of targeted and high-efficiency drug delivery to the central nervous system (CNS) nidus is main problem in treatment demyelinating disease. Extracellular vesicles (EVs) possess great promise as a vector given their advanced features. However, clinical applications are limited because inadequate targeting ability "dilution effects" after systemic administration. Neural stem cells (NSCs) supply plentiful source EVs on account extraordinary capacity for self-renewal. Here, we have...