A5066977157- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Vibrio bacteria research studies
- T-cell and Retrovirus Studies
- Cardiac electrophysiology and arrhythmias
- Glycosylation and Glycoproteins Research
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Helminth infection and control
- Aquaculture disease management and microbiota
- Multiple Myeloma Research and Treatments
- Transgenic Plants and Applications
- Immune Response and Inflammation
- Toxin Mechanisms and Immunotoxins
- HIV Research and Treatment
- Pharmacological Effects of Natural Compounds
- Spinal Cord Injury Research
- Nematode management and characterization studies
- Ion channel regulation and function
- Lymphoma Diagnosis and Treatment
- Escherichia coli research studies
- Cerebrovascular and Carotid Artery Diseases
- Parasite Biology and Host Interactions
- CAR-T cell therapy research
- Neurological Disease Mechanisms and Treatments
Tongji University
2018-2023
Shanghai Tenth People's Hospital
2018-2023
Shanghai Stomatological Hospital
2023
Berry Oncology (China)
2020-2023
Zhejiang University
2009-2022
Hong Kong Baptist University
2021-2022
Zhejiang Mariculture Research Institute
2021
Qingdao National Laboratory for Marine Science and Technology
2018-2021
Second Affiliated Hospital of Zhejiang University
2013-2021
Chinese Academy of Fishery Sciences
2021
The adjuvant activity of a single highly purified saponin from the soap bark tree Quillaja saponaria was evaluated by using it as component in an experimental vaccine containing rHIV-1 envelope protein (HIV-1 160D) adsorbed to alum. BALB/c mice immunized with formulations QS-21 produced significantly higher titers antibodies than vaccinated only alum-adsorbed HIV-1 160D. Potent amnestic antibody responses viral proteins were also induced. Ag-specific proliferative recombinant and three...
The ability of a saponin adjuvant, QS-21, to induce OVA-specific, class I MHC Ag-restricted CTL was investigated using different forms soluble OVA and adsorbed onto alum as immunogens. C57BL/6 mice were immunized with native or denatured in formulations that contained increasing quantities responses measured EL4 E.G7-OVA cells targets splenic mononuclear effectors. Ag-specific produced but only if the QS-21 adjuvant used. Similar induced alum-adsorbed when mixed not used alone. specific for...
Ischemic stroke is a serious public health problem worldwide. Here, we characterized the metabolite features of acute ischemic (AIS) using gas chromatography-mass spectrometry-based metabolomics. Forty AIS patients and 29 sex age-matched controls were recruited. The serum metabolic profiles significantly different between two groups. Compared to controls, had elevated levels lactate, carbonate glutamate (P<0.01), lowered alanine, citrate, glycine, isoleucine, leucine, serine, tyrosine,...
Abstract Insulin sensitivity progressively declines with age. Currently, the mechanism underlying age-associated insulin resistance remains unknown. Here, we identify membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) as a central regulator of during ageing. Ageing promotes MMP14 activation in insulin-sensitive tissues, which cleaves Receptor to suppress signaling. MT1-MMP inhibition restores expression, improving aged mice. The cleavage by also contributes obesity-induced and...
<h3>Importance</h3> Host immune dysregulation is associated with initiation and development of osteosarcoma. In addition, immunotherapy for osteosarcomas requires some knowledge the state patients. <h3>Objective</h3> To perform an immunogenomic landscape analysis based on The Cancer Genome Atlas (TCGA) project, which provides osteosarcoma samples clinical information. <h3>Design, Setting, Participants</h3> This genetic association study was conducted from July 20, 2020, to September as a...
Marek's disease (MD) has been occurring with increasing frequency in chickens recent years. To our knowledge, however, there no report of the very virulent plus (vv+) MDV field isolate China. Studies have shown that dual infection immunosuppressive viruses such as chicken infectious anemia virus (CIAV) occurs frequently developing MD. In this study, we performed a designed set vivo experiments, which comprised five different groups chickens, including group CVI988/Rispens vaccinated infected...
ABSTRACT Cholera is an acute diarrheal disease that caused by the gram-negative bacterium Vibrio cholerae . The low efficacy of currently available killed-whole-cell vaccines and reactinogenicity coupled with potential reversion live have thus far precluded widespread vaccination for control cholera. Recent studies on molecular nature virulence components contribute to V. pathogenesis provided insights into possible approaches development a defined subunit cholera vaccine. Genetic analysis...
The nematophagous fungus Duddingtonia flagrans has been investigated as a biological agent for the control of gastrointestinal nematodes infecting domestic animals in other countries. However, D. not detected China. In this study 1,135 samples were examined from 2012 to 2014; 4 isolates (SDH 035, SDH 091, SFH 089, SFG 170) obtained feces and dung compost. then characterized morphologically. 035 strain was by sequencing ITS1-5.8S rDNA-ITS2 region. A BLAST search showed that (GenBank KP257593)...
Background: Osteocalcin is related to energy metabolism, memory and the acute stress response, suggesting a relationship between bone brain.The need explore effect of osteocalcin on ischemic stroke therefore urgent.Results: Patients with better outcomes had higher serum levels than those whose NIHSS scores did not improve.Multivariable logistic regression analysis showed acceptable performance (area under curve = 0.766).The promotion neuron survival was confirmed by Cell Counting Kit-8...
Objective To determine if the addition of recombinant (r) human interleukin (IL)-12 enhances in vitro proliferative responses to Mycobacterium avium peripheral blood mononuclear cells (PBMC) from HIV-positive donors with CD4 cell counts < 100 × 106/l. Design and methods PBMC virulent avirulent serovars M. presence absence exogenously added IL-12 were determined 24 11 HIV-negative by 3H-thymidine uptake assay. Changes CD8 populations after treatment stimulation analyzed FACS. Results...
A total of 1502 samples, including feces sheep (793) and cattle (348), pasture soil (118), dung compost (147) barn (96), were examined between October 2012 August 2014 to discover potential strains nematophagous fungi for the biological control livestock‐parasitic nematodes. These samples collected from 87 sites located in 48 counties 20 provinces (autonomous regions/municipalities) China. Fungi identified down a species level. Four hundred seventy‐seven isolates, which distributed 8 genera...
The present study aimed to examine the universal gene expression signature and underlying molecular mechanisms involved in progression of carotid atherosclerotic plaques. dataset, GSE28829, containing 13 early 16 advanced plaques was selected for analysis. differentially expressed genes (DEGs) were identified analyzed using bioinformatics analyses, including cluster analysis, Gene Ontology (GO) pathway enrichment analyses. Finally, a protein‑protein interaction (PPI) constructed analyzed. A...