A5109491599- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Cancer-related gene regulation
- Phytochemistry and Biological Activities
- Caveolin-1 and cellular processes
- Epigenetics and DNA Methylation
- Protein Interaction Studies and Fluorescence Analysis
- Ferroptosis and cancer prognosis
- Drug Transport and Resistance Mechanisms
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Oral Health Pathology and Treatment
- RNA modifications and cancer
- Extracellular vesicles in disease
- Inflammatory mediators and NSAID effects
- Surfactants and Colloidal Systems
- Plant-Derived Bioactive Compounds
- PARP inhibition in cancer therapy
- Glutathione Transferases and Polymorphisms
- Ion Transport and Channel Regulation
- Cerebrovascular and Carotid Artery Diseases
- Regional Development and Environment
- Neurological diseases and metabolism
- Retinoids in leukemia and cellular processes
China Medical University
2013-2024
Liaocheng University
2023
Nanjing Tech University
2023
Air Force Medical University
2018-2022
Xijing Hospital
2018-2022
Dalian Medical University
2022
Beijing University of Chinese Medicine
2017-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2021
Shandong University
2021
Kunming Medical University
2021
Ischemic stroke is a serious public health problem worldwide. Here, we characterized the metabolite features of acute ischemic (AIS) using gas chromatography-mass spectrometry-based metabolomics. Forty AIS patients and 29 sex age-matched controls were recruited. The serum metabolic profiles significantly different between two groups. Compared to controls, had elevated levels lactate, carbonate glutamate (P<0.01), lowered alanine, citrate, glycine, isoleucine, leucine, serine, tyrosine,...
Aerobic glycolysis enables cancer cells to rapidly take up nutrients (e.g., nucleotides, amino acids, and lipids) incorporate them into the biomass needed produce a new cell. In contrast existing chemotherapy/radiotherapy strategies, inhibiting aerobic limit adenosine 5′-triphosphate (ATP) yield is highly efficient approach for suppressing tumor cell proliferation. However, most, if not all, current inhibitors of cause significant adverse effects because their nonspecific delivery...
Abstract The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in play crucial roles metastasis process. Shifting tumor-promoting M2-like TAMs toward M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and secretion inhibitory factors, may be a potential therapeutic strategy cancer treatment. We first cloned NDRG2 (N-myc downstream-regulated gene 2) verified its role multiple solid tumors, including...
Abstract The farnesoid X receptor (FXR) is a key metabolic and homeostatic regulator in the liver. In present work, we identify novel role of FXR antagonizing c-Jun N-terminal kinase (JNK) signaling pathway liver carcinogenesis by activating superoxide dismutase 3 (SOD3) transcription. Compared with wild-type mouse liver, FXR−/− showed elevated JNK phosphorylation. JNK1 deletion suppressed increase diethylnitrosamine-induced tumor number mice. These results suggest that plays...
The flower of Edgeworthia gardneri (Wall.) Meisn is commonly used in beverage products Tibet and has potential health benefits for diabetes. However, the mechanisms underlying anti-insulin resistance (IR) action E. are not fully understood. This study aims to investigate effects water extract (WEE) on IR palmitate (PA)-exposed HepG2 hepatocytes. WEE was characterized by UPLC analysis. PA-treated cells were selected as cell model. viability determined using MTT assay. Moreover, glucose...
Charged multivesicular body protein 3 (CHMP3) is an elemental constituent of the endosomal sorting complex required for transport (ESCRT) III, whose function as a tumor susceptibility gene in development liver cancer remains unclear. CHMP3 was found to be associated with pyroptosis by bioinformatics analysis data from patients hepatocellular carcinoma (HCC) The Cancer Genome Atlas database. It aimed explore role and potential mechanisms cancer. expression at tissue level examined using...
The tea-like beverage Stevia rebaudiana Bertoni (Stevia) is popular in China because it reduces blood glucose and has a sweet taste. In this work, comprehensive quality assessment of led to the discovery five phenylethanoid glycosides, namely steviophethanoside (1), cuchiloside (2), salidroside (3), icariside D (4), tyrosol (5). Of them, compound 1 novel compound. Mass spectrometry NMR spectroscopy were employed confirm absolute configuration. A hydrolytic step with 4 N TFA at 95 °C for h...
Cardiomyocyte apoptosis is a characteristic of variety cardiac diseases, including myocardial infarction (MI). Krüppel-like factor 15 (KLF15) transcription Krüppel family that plays an important part in cardiovascular diseases. However, the function and underlying mechanism KLF15 MI remain unknown. The expression was downregulated both ischemic myocardium mice model hypoxia-treated neonatal rat ventricular myocytes (NRVCs). overexpression mediated by adeno-associated virus significantly...
Abstract Background and Aims The secretion of bile salts transported by the salt export pump (BSEP) is primary driving force for generation flow; thus, it closely related to formation cholesterol stones. Caveolin‐1 (Cav‐1), an essential player in cell signalling endocytosis, known co‐localize with cholesterol‐rich membrane domains. This study illustrates role Cav‐1 BSEP stone formation. Methods Adult male C57BL/6 mice were used as animal model. HepG2 cells cultured under different...
N6-methyladenosine (m6A) modification is the most common mRNA that considered a new layer of epigenetic regulation. Demethylase fat mass and obesity-associated protein (FTO) are important in dynamic regulation m6A, but their role gastric cancer (GC) not fully understood. This study revealed FTO CDKAL1 were up-regulated GC cells tissue. downstream target FTO-mediated m6A modification, with promoting cell proliferation through inducing mitochondrial fusion, eventually causing chemoresistance....
Autophagy disorders are linked to human cancer, and the details of their mechanisms remain unclear.To investigate regulatory role PRMT5 in autophagy breast cancer cells.Human adenocarcinoma cell lines (MDA-MB-231, MCF7) were cultured. Plasmids overexpression down-regulation transfected into MDA-MB-231 MCF7 cells. The MTT assay was used determine proliferation A western blotting verify expression autophagy-associated molecules. Immunofluorescence applied observe GFP-LC3.The decreased...
Xiao Qing Long Tang (literally "Minor blue dragon decoction" in Chinese), a traditional Chinese formula, is prescribed to treat respiratory diseases. However, only few studies have been reported on its anti-inflammatory mechanisms. In this study, we investigated the inhibitory effects of essential oil inflammatory mediators and explored mechanisms action XQEO lipopolysaccharide (LPS)-stimulated RAW264.7 cells. was prepared via steam distillation characterized by GC-MS analysis. MTT Griess...
Cervical cancer is one of the most common types gynecological tumor, and thus identifying complementary or substitute treatment methods to treat cervical important. The present study aimed evaluate effect arsenic trioxide (ATO), a traditional Chinese medicine, on cells its underlying mechanism. MTT, colony formation Transwell assays were performed investigate effects different concentrations ATO cell proliferation invasion, respectively. Western blotting reverse transcription-quantitative...
Background: The association of opioid binding protein cell adhesion molecule-like (OPCML) gene methylation with ovarian cancer risk remains unclear. Methods: We identified eligible studies by searching the PubMed, Web Science, ScienceDirect, and Wanfang databases. Odds ratios (ORs) 95% confidence intervals (95% CIs) were used to determine OPCML risk. Meta-regression subgroup analysis assess sources heterogeneity. Additionally, we analyzed Gene Expression Omnibus (GEO) Cancer Genome Atlas...
A 65-year-old male presented with recurrent palpitation and fatigue over one year. Lab tests revealed him hyperinsulinaemic hypoglycemia. Insulin autoimmune antibody was repeatedly negative. Imaging of the pancreas seemed to be normal. Insulin-insulin complexes were detected by polyethylene glycol precipitation gel filtration chromatography, thus diagnosis insulin syndrome suggested. By adjusting diet administration acarbose, all symptoms evidently relieved. (Chin J Endocrinol Metab, 2017,...
Objective: To investigate the anti-inflammatory effects of total flavonoids from Saussurea involucrata on lipopolysaccharides (LPS)-stimulated murine RAW264.7 macrophages and explore its underlying mechanism action. Methods: Total were extracted using chromatographic column method. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. The production nitric oxide detected Griess assay release cytokines (IL-10 TNF-α) chemokines (MCP-1, MIP-1a,...