A5068021274- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Sleep and Wakefulness Research
- Infant Health and Development
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
- Sleep and related disorders
- EEG and Brain-Computer Interfaces
- Zebrafish Biomedical Research Applications
- Genetics and Neurodevelopmental Disorders
- Anesthesia and Neurotoxicity Research
- Sport Psychology and Performance
- Autism Spectrum Disorder Research
- Action Observation and Synchronization
- Bat Biology and Ecology Studies
- Gambling Behavior and Treatments
- Animal Vocal Communication and Behavior
- Circadian rhythm and melatonin
- Insect and Pesticide Research
Université Paris-Saclay
2009-2024
Institut des Neurosciences Paris-Saclay
2016-2024
Centre National de la Recherche Scientifique
2015-2024
Université Paris-Sud
2010-2023
CEA Paris-Saclay
2020-2022
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2020-2022
Laboratoire de Psychologie et NeuroCognition
2017
Université Paris Cité
2013
Decision Research
2011-2012
Institut Pasteur
1998-2010
The role in spatial divided and sustained attention of D1 D2-like dopamine (DA) receptors the rat prelimbic medial prefrontal cortex (mPFC) was investigated a five-choice serial reaction time task. Rats were trained to detect brief flashes light (0.5–0.25 sec) presented randomly array five apertures. When performance stabilized, animals received bilateral microinfusions either DA receptor antagonist SCH 23390, agonist SKF 38393, or D2 sulpiride into mPFC. two groups, with low (<75%...
Autism spectrum conditions (ASCs) are heritable characterized by impaired reciprocal social interactions, deficits in language acquisition, and repetitive restricted behaviors interests. In addition to more complex genetic susceptibilities, even mutation of a single gene can lead ASC. Several such monogenic ASC forms caused loss-of-function mutations genes encoding regulators synapse function neurons, including NLGN4. We report that mice with the murine NLGN4 ortholog Nlgn4, which encodes...
This study examined the effects of lesions prelimbic area rat prefrontal cortex on acquisition and retention nonmatching (NMTS) matching-to-sample (MTS) tasks. Both tasks involved a reference working memory component, but only was impaired by lesions. A comparison 2 revealed quantitatively similar deficits in postoperatively trained rats. In preoperatively rats, however, were more important MTS task than NMTS task. addition, an effect interference between successive trials observed not...
Social interactions in mice are frequently analysed genetically modified strains order to get insight of disorders affecting social such as autism spectrum disorders. Different types have been described, mostly between females and pups, adult males females. However, we recently showed that could also encompass cognitive motivational features. During interactions, rodents emit ultrasonic vocalizations (USVs), but it remains unknown if call differently used depending the context they...
Nicotine enhances several cognitive and psychomotor behaviors, nicotinic antagonists cause impairments in tasks requiring effort. To explore the contribution of receptors to complex functions, we developed an automated method investigate sequential locomotor behavior mouse analysis social behavior. We show that, β2 -/- mutant, high-order spatiotemporal organization behavior, together with conflict resolution interaction, is selectively dissociated from low-level, more automatic motor...
ABSTRACT: The monoaminergic and cholinergic systems are implicated in different forms of behavioral arousal that can be dissected terms their forebrain targets the nature processes they modulate distinct regions. Thus, evidence rats with selective neurochemical manipulations tested behaviorally using an analog attentional task developed for human subjects indicates coeruleo‐cortical noradrenergic system is divided attention, basal stimulus detection, mesostriatal mesolimbic dopaminergic...
Rats with medial prefrontal cortical lesions were tested in a modified water maze navigation task. In Stage 1, the rats trained to locate hidden platform from single start location. They then subjected series of trials during which second position was used (Stage 2). 3, had navigate new goal location 2 experienced positions. 4 required same as starting distinct Finally, probe trial no conducted. impaired only 4. This deficit specific positions newly introduced this stage, suggesting...
Chronic nicotine exposure results in long-term homeostatic regulation of nicotinic acetylcholine receptors (nAChRs) that play a key role the adaptative cellular processes leading to addiction. However, relative contribution different nAChR subunits this process is unclear. Using genetically modified mice and pharmacological manipulations, we provide behavioral, electrophysiological, evidence for mechanism by which chronic triggers opposing differentially mediated β2*- vs. α7*nAChRs. These...
Social behavior is a defining mammalian feature that integrates emotional and motivational processes with external rewarding stimuli. It thus an appropriate readout for complex behaviors, yet its neuronal molecular bases remain poorly understood. In this study, we investigated the role of mouse prefrontal area, particularly involvement β2-subunit nicotinic receptors (β2∗-nAChRs) in paradigm social concurrent motivations. We previously observed mice lacking β2∗-nAChRs (β2-/-) display...
Acetylcholine (ACh) is a known modulator of the activity dopaminergic (DAergic) neurons through stimulation nicotinic ACh receptors (nAChRs). Yet, subunit composition and specific location nAChRs involved in DA-mediated locomotion remain to be established vivo . Mice lacking β2 (β2KO) display striking hyperactivity open field, which suggests an imbalance DA neurotransmission. Here, we performed selective gene rescue functional β2*-nAChRs either substantia nigra pars compacta (SNpc) or...
Abstract Solving challenging (‘effortful’) problems is known to involve the dorsal and dorsolateral prefrontal cortex in normal volunteers, although there considerable individual variation. In this functional magnetic resonance imaging study, we show that healthy subjects with different levels of performance Tower London planning task exhibit patterns brain activation. All exhibited significant bilateral activation cortex, anterior posterior cingulate areas parietal cortex. However,...