A5083411884- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Rare-earth and actinide compounds
- Nuclear Materials and Properties
- Paleontology and Stratigraphy of Fossils
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Primate Behavior and Ecology
- Fusion materials and technologies
- High-pressure geophysics and materials
- stochastic dynamics and bifurcation
- Geology and Paleoclimatology Research
- Geological and Geophysical Studies Worldwide
- Geological formations and processes
- Ultrasound Imaging and Elastography
- Photochromic and Fluorescence Chemistry
- Zebrafish Biomedical Research Applications
- Neurobiology and Insect Physiology Research
- Plant and Biological Electrophysiology Studies
- Ultrasound and Hyperthermia Applications
Centre National de la Recherche Scientifique
2016-2025
ESPCI Paris
2021-2025
Université Paris Sciences et Lettres
2021-2025
Laboratoire Plasticité du Cerveau
2021-2025
Inserm
2015-2024
Sorbonne Université
2015-2024
Neurosciences Paris-Seine
2015-2024
Institut de Biologie Paris-Seine
2016-2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
1994-2024
CEA Valduc
1998-2024
Summary The formation of biofilm results in a major lifestyle switch that is thought to affect the expression multiple genes and operons. We used DNA arrays study global effect on gene mature Escherichia coli K‐12 biofilm. show that, when compared with exponential growth phase, 1.9% showed consistent up‐ or downregulation by factor greater than two, 10% E. genome significantly differentially expressed. functions induced these conditions correspond stress response as well energy production,...
Repeated traumatic events induce long-lasting behavioral changes that are key to organism adaptation and affect cognitive, emotional, social behaviors. Rodents subjected repeated instances of aggression develop enduring aversion increased anxiety. Such aggressions trigger a stress response, resulting in glucocorticoid release activation the ascending dopamine (DA) system. We bred mice with selective inactivation gene encoding receptor (GR) along DA pathway, exposed them aggressions. GR...
Nicotine is the primary psychoactive component of tobacco. Its reinforcing and addictive properties depend on nicotinic acetylcholine receptors (nAChRs) located within mesolimbic axis originating in ventral tegmental area (VTA). The roles oligomeric assembly subunit α4- α6-containing nAChRs dopaminergic (DAergic) neurons are much debated. Using subunit-specific knockout mice targeted lentiviral re-expression, we have determined dependence intracranial nicotine self-administration (ICSA) into...
High level of organisation in sequences ultrasonic vocalisations.• Very limited sex-related variations
Nicotine enhances several cognitive and psychomotor behaviors, nicotinic antagonists cause impairments in tasks requiring effort. To explore the contribution of receptors to complex functions, we developed an automated method investigate sequential locomotor behavior mouse analysis social behavior. We show that, β2 -/- mutant, high-order spatiotemporal organization behavior, together with conflict resolution interaction, is selectively dissociated from low-level, more automatic motor...
The study of the neural basis olfaction is important both for understanding sense smell and mechanisms computation. In olfactory bulb (OB), spatial patterning sensory inputs synaptic interactions crucial processing odor information, although this alone not sufficient. Recent studies have suggested that representations may already be distributed dynamic in first relay. growing evidence demonstrating a functional role temporal structure bulbar neuronal activity supports assumption. However,...
Chronic nicotine exposure results in long-term homeostatic regulation of nicotinic acetylcholine receptors (nAChRs) that play a key role the adaptative cellular processes leading to addiction. However, relative contribution different nAChR subunits this process is unclear. Using genetically modified mice and pharmacological manipulations, we provide behavioral, electrophysiological, evidence for mechanism by which chronic triggers opposing differentially mediated β2*- vs. α7*nAChRs. These...
Mutations in NLGN4X have been identified individuals with autism spectrum disorders and other neurodevelopmental disorders. A previous study reported that adult male mice lacking neuroligin4 (Nlgn4) displayed social approach deficits the three-chambered test, altered aggressive behaviors reduced ultrasonic vocalizations. To replicate extend these findings, independent comprehensive analyses of autism-relevant behavioral phenotypes were conducted later generations same line Nlgn4 mutant at...
Mice emit ultrasonic vocalizations in different contexts throughout development and adulthood. These vocal signals are now currently used as proxies for modeling the genetic bases of communication deficits. Characterizing behavior mouse models carrying mutations genes associated with neuropsychiatric disorders such autism spectrum will help to understand mechanisms leading social We provide here protocols reliably elicit pups adult mice. This standardization reduce inter-study variability...
Epidemiological studies report strong association between mood disorders and tobacco addiction. This high comorbidity requires adequate treatment but the underlying mechanisms are unknown. We demonstrate that nicotine exposure, independent of drug withdrawal effects, increases stress sensitivity, a major risk factor in disorders. Nicotine concur to induce long-lasting cellular adaptations within dopamine (DA) system. interplay is underpinned by marked remodeling nicotinic systems, causing...
Acetylcholine (ACh) is a known modulator of the activity dopaminergic (DAergic) neurons through stimulation nicotinic ACh receptors (nAChRs). Yet, subunit composition and specific location nAChRs involved in DA-mediated locomotion remain to be established vivo . Mice lacking β2 (β2KO) display striking hyperactivity open field, which suggests an imbalance DA neurotransmission. Here, we performed selective gene rescue functional β2*-nAChRs either substantia nigra pars compacta (SNpc) or...
Stressful life events are primary environmental factors that markedly contribute to depression by triggering brain cellular maladaptations. Dysregulation of ventral tegmental area (VTA) dopamine neurons has been causally linked the appearance social withdrawal and anhedonia, two classical manifestations depression. However, relevant inputs shape these signals remain largely unknown. We demonstrate chronic defeat (CSD) stress, a preclinical paradigm depression, causes marked hyperactivity...