A5022159078- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Olfactory and Sensory Function Studies
- Autism Spectrum Disorder Research
- Primate Behavior and Ecology
- Genetics and Neurodevelopmental Disorders
- Animal Vocal Communication and Behavior
- Infant Health and Development
- Neurobiology and Insect Physiology Research
- Animal testing and alternatives
- Biochemical Analysis and Sensing Techniques
- Memory and Neural Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Animal Behavior and Welfare Studies
- Advanced Sensor and Control Systems
- Psychology of Moral and Emotional Judgment
- Cellular transport and secretion
- Animal Genetics and Reproduction
- Chemical synthesis and alkaloids
- Neurogenesis and neuroplasticity mechanisms
- Gene Regulatory Network Analysis
- Computational Drug Discovery Methods
- Genetic Mapping and Diversity in Plants and Animals
Centre National de la Recherche Scientifique
2012-2024
Neurosciences Paris-Seine
2014-2024
Sorbonne Université
2014-2024
Inserm
2014-2024
Institut de Biologie Paris-Seine
2016-2024
Institut Clinique de la Souris
2023
Institut de génétique et de biologie moléculaire et cellulaire
2023
Université de Strasbourg
2023
Université Paris-Seine
2016
Sorbonne Paris Cité
2012-2013
High level of organisation in sequences ultrasonic vocalisations.• Very limited sex-related variations
Mutations in NLGN4X have been identified individuals with autism spectrum disorders and other neurodevelopmental disorders. A previous study reported that adult male mice lacking neuroligin4 (Nlgn4) displayed social approach deficits the three-chambered test, altered aggressive behaviors reduced ultrasonic vocalizations. To replicate extend these findings, independent comprehensive analyses of autism-relevant behavioral phenotypes were conducted later generations same line Nlgn4 mutant at...
Mice emit ultrasonic vocalizations in different contexts throughout development and adulthood. These vocal signals are now currently used as proxies for modeling the genetic bases of communication deficits. Characterizing behavior mouse models carrying mutations genes associated with neuropsychiatric disorders such autism spectrum will help to understand mechanisms leading social We provide here protocols reliably elicit pups adult mice. This standardization reduce inter-study variability...
Microglia, the innate immune cells of brain, engulf and eliminate cellular debris during brain injury disease. Recent observations have extended their roles to healthy but functional impact activated microglia on neural plasticity has so far been elusive. To explore this issue, we investigated role in function adult olfactory bulb network which both sensory afferents local microcircuits are continuously molded by arrival adult-born neurons. We show here that hosts a large population resident...
Abstract Long-term exposure to nicotine alters brain circuits and induces profound changes in decision-making strategies, affecting behaviors both related unrelated drug seeking consumption. Using an intracranial self-stimulation reward-based foraging task, we investigated mice the impact of chronic on midbrain dopamine neuron activity its consequence trade-off between exploitation exploration. Model-based archetypal analysis revealed substantial inter-individual variability with passively...
Nicotine intake is likely to result from a balance between the rewarding and aversive properties of drug, yet individual differences in neural activity that control aversion nicotine their adaptation during addiction process remain largely unknown. Using two-bottle choice experiment, we observed considerable heterogeneity nicotine-drinking profiles isogenic adult male mice, with about half mice persisting consumption even at high concentrations, whereas other stopped consuming. We found was...
Preclinical studies of psychiatric disorders require the use animal models to investigate impact environmental factors or genetic mutations on complex traits such as decision-making and social interactions. Here, we present a real-time method for behavior analysis mice housed in groups that couples computer vision, machine learning Triggered-RFID identification track monitor animals over several days enriched environments. The system extracts thorough list individual collective behavioral...
This work deals with the design of a "bio-oxidisable prodrug" strategy for development new central selective acetylcholinesterase inhibitors. prodrug approach is expected to reduce peripheral anticholinesterase activity responsible various side effects observed presently marketed AChE The these inhibitors in quinoline series roughly based on cyclic analogues rivastigmine. key activation step involves an oxidation N-alkyl-1,4-dihydroquinoline 1 corresponding quinolinium salt 2 unmasking...
<ns4:p>Ultrasonic vocalisation is a broadly used proxy to evaluate social communication in mouse models of neuropsychiatric disorders. The efficacy and robustness testing these suffer from limited knowledge the structure functions vocalisations as well way analyse data. We created <ns4:italic>mouseTube</ns4:italic>, an open database with web interface, facilitate sharing comparison ultrasonic data metadata attached recording file. Metadata describe 1) acquisition procedure,...
Abstract Alcohol and nicotine are the most widely co-abused drugs. Both modify activity of dopaminergic (DA) neurons Ventral Tegmental Area (VTA) lead to an increase in DA release Nucleus Accumbens, thereby affecting reward system. Evidences support hypothesis that distinct nicotinic acetylcholine receptors (nAChRs), molecular target (ACh) exogenous nicotine, also addition implicated response alcohol. The precise neuronal substrates this interaction however not well understood. Here we used...
Mouse models of autism can be used to study evolutionarily conserved mechanisms underlying behavioral abnormalities in social communication and repetitive behaviors. SHANK genes code for synaptic scaffolding proteins at excitatory synapses mutations all have been associated with autism. Here, we present three aspects the mutant mice deleted exon 16 Shank2. First, treated Shank2 methylphenidate rescue hyperactivity. Our failure do so suggests that hyperactivity displayed by is not related one...
The study of food aversion in humans by the induction illness is ethically unthinkable, and it difficult to propose a type that disgusting for everybody. However, although cheese considered edible most people, can also be perceived as particularly some individuals. As such, perception constitutes good model cerebral processes disgust aversion. In this study, we show higher percentage people are disgusted than other types food. Functional magnetic resonance imaging then reveals internal...
Mice emit ultrasonic vocalizations in different contexts throughout development and adulthood. These vocal signals are now currently used as proxies for modeling the genetic bases of communication deficits. Characterizing behavior mouse models carrying mutations genes associated with neuropsychiatric disorders such autism spectrum will help to understand mechanisms leading social We provide here protocols reliably elicit pups adult mice. This standardization reduce inter-study variability...
Individual animals differ in their traits and preferences, which shape social interactions, survival, susceptibility to disease, including addiction. Nicotine use is highly heterogenous has been linked the expression of personality traits. Although these relationships are well documented, we have limited understanding neurophysiological mechanisms that give rise distinct behavioral profiles connection nicotine susceptibility. To address this question, conducted a study using semi-natural...
Olfaction is determinant for the organization of rodent behavior. In a feeding context, rodents must quickly discriminate whether nutrient can be ingested or it represents potential danger to them. To understand learning processes that support food choice, aversive olfactory and flavor appetitive have been extensively studied. contrast, little currently known about its mechanisms. We designed new paradigm study conditioned preference in rats. After 8 days exposure pair odors (one paired with...
Summary Individuality is a ubiquitous and well-conserved feature among animal species. The behavioral patterns of individual animals affect their respective role in the ecosystem prospects for survival. Even though some factors shaping individuality have been identified, mechanisms underlying individuation are poorly understood generally considered to be genetics-based. Here we devised large environment where mice live continuously, observed that individuality, measured by both social...
Abstract Nicotine intake is likely to result from a balance between the rewarding and aversive properties of drug, yet individual differences in neural activity that control aversion nicotine their adaptation during addiction process remain largely unknown. Using two-bottle choice experiment, we observed high heterogeneity nicotine-drinking profiles isogenic adult male mice, with about half mice persisting consuming even at concentrations, whereas other stopped consuming. We found was...