A5039524197- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Botulinum Toxin and Related Neurological Disorders
- Animal Ecology and Behavior Studies
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Primate Behavior and Ecology
- Pain Management and Treatment
- Musculoskeletal pain and rehabilitation
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Olfactory and Sensory Function Studies
Centre National de la Recherche Scientifique
2022-2025
ESPCI Paris
2023-2025
Laboratoire Plasticité du Cerveau
2022-2025
Université Paris Sciences et Lettres
2024-2025
Institut de Biologie Paris-Seine
2018-2024
Sorbonne Université
2022-2024
Inserm
2022-2024
Neurosciences Paris-Seine
2022-2024
Initial anatomical and physiological studies suggested that sensory information relayed from the periphery by thalamus is serially processed in primary cortical areas. It thought to propagate layer 4 (L4) up L2/3 down L5, which constitutes main output of cortex. However, more recent experiments point toward existence a direct processing thalamic input L5 neurons. Therefore, role neurons operated now highly debated. Using cell type-specific reversible optogenetic manipulations somatosensory...
Summary Social organization and division of labor are fundamental to animal societies, but how do these structures emerge from individual interactions, what role does neuromodulation play in shaping them? Using behavioral tracking a semi-natural environment, neural recordings, computational models integrating reinforcement social learning, we show that groups three isogenic mice spontaneously develop specialized roles while solving foraging task requiring decisions under constraints....
Cav3.2 T-type calcium channel is a major molecular actor of neuropathic pain in peripheral sensory neurons, but its involvement at the supraspinal level almost unknown. In anterior pretectum (APT), hub connectivity somatosensory system involved perception, we show that channels are expressed subpopulation GABAergic neurons coexpressing parvalbumin (PV). these PV-expressing contribute to high-frequency-bursting activity, which increased spared nerve injury model neuropathy. Specific deletion...
Individual animals differ in their traits and preferences, which shape social interactions, survival, susceptibility to disease, including addiction. Nicotine use is highly heterogenous has been linked the expression of personality traits. Although these relationships are well documented, we have limited understanding neurophysiological mechanisms that give rise distinct behavioral profiles connection nicotine susceptibility. To address this question, conducted a study using semi-natural...
How nicotine acts on developing neurocircuitry in adolescence to promote later addiction vulnerability remains largely unknown, but may hold the key for informing more effective intervention efforts. We found transient exposure early adolescent (PND 21-28) male mice was sufficient produce a marked adulthood 60 + ), associated with disrupted functional connectivity dopaminergic circuits. These showed persistent adolescent-like behavioral and physiological responses nicotine, suggesting that...
Abstract Nicotine use during adolescence is largely associated with negative long-term outcomes, including addiction to nicotine in adulthood. How acts on developing neurocircuitry remains unknown, but may hold the key for informing more effective intervention efforts. We found transient exposure early was sufficient adult mice show a marked vulnerability nicotine. Brain-wide activity mapping showed that these had an enhanced response acute injection and widespread disruption of functional...
Abstract Cav3.2 T-type calcium channel is a major molecular actor of neuropathic pain in peripheral sensory neurons, but its involvement at the supra-spinal level almost unknown. In Anterior Pretectum (APT), hub connectivity somatosensory system involved perception, we show that channels are expressed sub-population GABAergic neurons co-expressing parvalbumin (PV). these PV-expressing contribute to high frequency bursting activity, which increased spared nerve injury model neuropathy....