A5060336002- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Diffusion and Search Dynamics
- Nicotinic Acetylcholine Receptors Study
- stochastic dynamics and bifurcation
- Cellular transport and secretion
- Transcranial Magnetic Stimulation Studies
- Advanced Memory and Neural Computing
- Microtubule and mitosis dynamics
- Cell Image Analysis Techniques
- Genetic Mapping and Diversity in Plants and Animals
- Axon Guidance and Neuronal Signaling
- Hearing, Cochlea, Tinnitus, Genetics
- Neurological disorders and treatments
- Neuroendocrine regulation and behavior
- Mitochondrial Function and Pathology
- Musculoskeletal pain and rehabilitation
- Receptor Mechanisms and Signaling
Centre National de la Recherche Scientifique
2005-2022
Sorbonne Université
2005-2022
Neurosciences Paris-Seine
2017-2022
Inserm
2017-2022
Institut de Biologie Paris-Seine
2017-2022
University of Pennsylvania
2010-2017
Gènes, synapses et cognition
2017
Université Paris Cité
2008
Unit of Functional and Adaptive Biology
2006
An inhibitor causes neuronal excitation Glycine is thought to be primarily an inhibitory neurotransmitter. However, it also acts as a coagonist on excitatory N -methyl-D-aspartate (NMDA) receptors. Otsu et al. examined the function of NMDA receptor subunit combination GluN1/GluN3A in medial habenula (MHb) adult mice. This MHb neurons activated by glycine released from astrocytes. Activation receptors depolarization and increased spiking neurons. Reducing GluN3A levels blocks conditioned...
Initial anatomical and physiological studies suggested that sensory information relayed from the periphery by thalamus is serially processed in primary cortical areas. It thought to propagate layer 4 (L4) up L2/3 down L5, which constitutes main output of cortex. However, more recent experiments point toward existence a direct processing thalamic input L5 neurons. Therefore, role neurons operated now highly debated. Using cell type-specific reversible optogenetic manipulations somatosensory...
Human and experimental studies indicate that molecular genetic changes in GABA(A) receptors may underlie the expression of spike-and-waves discharges (SWDs) occurring during absence seizures. However, full spectrum defects underlying these seizures has only been partially elucidated, functional profiles putative abnormal protein(s) within thalamocortical network are undefined, pathophysiological mechanism(s) by which proteins would lead to paroxysms poorly understood. Here we investigated...
Both human investigations and studies in animal models have suggested that abnormalities GABA(A) receptor function a potential role the pathophysiology of absence seizures. Recently we showed that, prior to seizure onset, IPSCs thalamic reticular (NRT) neurons genetic epilepsy rats from Strasbourg (GAERS) had 25% larger amplitude, 40% faster decay 45% smaller paired-pulse depression than those nonepileptic control (NEC) rats. By means novel mathematical description, properties both GAERS NEC...
A growing number of in vivo experiments shows that high frequency bursts action potentials can be recorded thalamocortical neurons awake animals. The mechanism underlying these bursts, however, remains controversial, because they have been proposed to depend on T-type Ca(2+) channels are inactivated at the depolarized membrane usually associated with state. Here, we show transient potentiation T current amplitude, which is induced by neuronal depolarization, drastically increases probability...
Cortical neurons are organized in columns, distinguishable by their physiological properties and input-output organization. Columns thought to be the fundamental information-processing modules of cortex. The barrel cortex rats mice is an attractive model system for study cortical because each column defined a layer 4 (L4) structure called barrel, which can clearly visualized. A great deal information has been collected regarding connectivity cortex, but nature input given L4 remains unclear....
Cav3.2 T-type calcium channel is a major molecular actor of neuropathic pain in peripheral sensory neurons, but its involvement at the supraspinal level almost unknown. In anterior pretectum (APT), hub connectivity somatosensory system involved perception, we show that channels are expressed subpopulation GABAergic neurons coexpressing parvalbumin (PV). these PV-expressing contribute to high-frequency-bursting activity, which increased spared nerve injury model neuropathy. Specific deletion...
Summary Purpose: Most common forms of human epilepsy result from a complex combination polygenetic and environmental factors. Quantitative trait locus (QTL) mapping is first step toward the nonbiased discovery epilepsy‐related candidate genes. QTL studies susceptibility to induced seizures in mouse strains have consistently converged on distal region chromosome 1 as major phenotypic determinant; however, its influence spontaneous remains unclear. In present study we characterized allelic...
Rodents explore their immediate environment using whiskers. Such exploration leads to micromotions, which contain many high-frequency (50-200 Hz) components. High-frequency whisker motion is represented faithfully in the temporal structure of spike trains trigeminal neurons. However, representation sensory inputs cortex not fully understood. By combining extracellular and intracellular recordings rat somatosensory thalamus, we show that inputs, either sinusoidal or white noise, elicit...
Abstract Cav3.2 T-type calcium channel is a major molecular actor of neuropathic pain in peripheral sensory neurons, but its involvement at the supra-spinal level almost unknown. In Anterior Pretectum (APT), hub connectivity somatosensory system involved perception, we show that channels are expressed sub-population GABAergic neurons co-expressing parvalbumin (PV). these PV-expressing contribute to high frequency bursting activity, which increased spared nerve injury model neuropathy....