A5026444570- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Estrogen and related hormone effects
- Botulinum Toxin and Related Neurological Disorders
- Musculoskeletal pain and rehabilitation
- Receptor Mechanisms and Signaling
- Inflammatory mediators and NSAID effects
- Computational Drug Discovery Methods
- Hormonal Regulation and Hypertension
Inserm
2022-2023
Université Clermont Auvergne
2022-2023
Clermont Université
2023
Abstract The synthetic peptide ERα17p (sequence: PLMIKRSKKNSLALSLT), which corresponds to the 295–311 region of human estrogen receptor α (ERα), induces apoptosis in breast cancer cells. In mice and at low doses, it promotes not only decrease size xenografted triple-negative tumors, but also anti-inflammatory anti-nociceptive effects. Recently, we have shown that these effects were due its interaction with seven-transmembrane G protein-coupled GPER. Following modeling studies, C-terminus...
Cav3.2 T-type calcium channel is a major molecular actor of neuropathic pain in peripheral sensory neurons, but its involvement at the supraspinal level almost unknown. In anterior pretectum (APT), hub connectivity somatosensory system involved perception, we show that channels are expressed subpopulation GABAergic neurons coexpressing parvalbumin (PV). these PV-expressing contribute to high-frequency-bursting activity, which increased spared nerve injury model neuropathy. Specific deletion...
Abstract Cav3.2 T-type calcium channel is a major molecular actor of neuropathic pain in peripheral sensory neurons, but its involvement at the supra-spinal level almost unknown. In Anterior Pretectum (APT), hub connectivity somatosensory system involved perception, we show that channels are expressed sub-population GABAergic neurons co-expressing parvalbumin (PV). these PV-expressing contribute to high frequency bursting activity, which increased spared nerve injury model neuropathy....