A5038892166- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Mental Health Research Topics
- Zebrafish Biomedical Research Applications
- Animal Behavior and Reproduction
- Primate Behavior and Ecology
Laboratoire Plasticité du Cerveau
2024
ESPCI Paris
2021-2024
Université Paris Sciences et Lettres
2021-2024
Centre National de la Recherche Scientifique
2019-2024
Université Paris-Seine
2020-2023
Institut de Biologie Paris-Seine
2019-2023
Inserm
2019-2022
Sorbonne Université
2019-2022
Neurosciences Paris-Seine
2019-2022
Abstract Long-term exposure to nicotine alters brain circuits and induces profound changes in decision-making strategies, affecting behaviors both related unrelated drug seeking consumption. Using an intracranial self-stimulation reward-based foraging task, we investigated mice the impact of chronic on midbrain dopamine neuron activity its consequence trade-off between exploitation exploration. Model-based archetypal analysis revealed substantial inter-individual variability with passively...
Abstract Can decisions be made solely by chance? variability intrinsic to the decision-maker or is it inherited from environmental conditions? To investigate these questions, we designed a deterministic setting in which mice are rewarded for non-repetitive choice sequences, and modeled experiment using reinforcement learning. We found that progressively increased their variability. Although an optimal strategy based on sequences learning was theoretically possible would more rewarding,...
The neural mechanisms by which animals initiate goal-directed actions, choose between options, or explore opportunities remain unknown. Here, we develop a spatial gambling task in mice, to obtain intracranial self-stimulation rewards, self-determine the initiation, direction, vigor, and pace of their actions based on knowledge outcomes. Using electrophysiological recordings, pharmacology, optogenetics, identify sequence oscillations firings ventral tegmental area (VTA), orbitofrontal cortex...
Abstract Efficient decision-making requires two key processes: learning values from actions and identifying a set of relevant to learn in given context. While dopamine (DA) is well-known substrate for signaling reward prediction errors (RPEs) selected adjust behavior, the process establishing switching between action representations still poorly understood. To address this gap, we used fiber photometry computational modelling three-armed bandit task where mice learned seek rewards delivered...
Abstract Can our choices just be driven by chance? To investigate this question, we designed a deterministic setting in which mice reinforce non-repetitive choice sequences, and modeled it using reinforcement learning. Mice progressively increased their variability memory-free, pseudo-random selection, rather than learning complex sequences. Our results demonstrate that decision-making process can self-generate randomness even when the rules governing reward delivery are not stochastic.
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Summary Goal-directed choices that are not triggered by external cues arise from internal representations of the outcomes. The use a stimulus to specify when act, which option take, or whether explore, has led consider reward circuit as feedforward set modules carrying independent computations. Here, we develop an uncued task in mice self-determine initiation, direction, vigor and pace their actions based on knowledge Using electrophysiological recordings, pharmacology optogenetics, identify...
Summary Long-term exposure to nicotine alters brain circuits and induces profound changes in decision-making strategies, affecting behaviors both related unrelated drug seeking consumption. Using an intracranial self-stimulation reward-based foraging task, we investigated the impact of chronic on trade-off between exploitation exploration, role ventral tegmental area (VTA) dopamine (DA) neuron activity nicotine-seeking. Model-based archetypal analysis revealed a substantial inter-individual...