A5082850455- Trace Elements in Health
- Autism Spectrum Disorder Research
- Heavy Metal Exposure and Toxicity
- Nanoparticle-Based Drug Delivery
- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Child Nutrition and Feeding Issues
- Cellular transport and secretion
- RNA regulation and disease
- Gut microbiota and health
- Graphene and Nanomaterials Applications
- S100 Proteins and Annexins
- Nanoparticles: synthesis and applications
- Pharmacological Effects and Toxicity Studies
- Advanced Drug Delivery Systems
- Genomic variations and chromosomal abnormalities
- Lipid Membrane Structure and Behavior
- Barrier Structure and Function Studies
- Ubiquitin and proteasome pathways
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
University of Limerick
2017-2025
Analog Devices (Ireland)
2022-2024
Universität Ulm
2009-2017
Neurology, Inc
2014-2015
Stanford University
2011-2012
REVIEW article Front. Psychiatry, 18 January 2013Sec. Molecular Psychiatry Volume 3 - 2012 | https://doi.org/10.3389/fpsyt.2012.00118
Mutations in several postsynaptic proteins have recently been implicated the molecular pathogenesis of autism and spectrum disorders (ASDs), including Neuroligins, Neurexins, members ProSAP/Shank family, thereby suggesting that these genetic forms may share common synaptic mechanisms. Initial studies ASD-associated mutations ProSAP2/Shank3 support a role for this protein glutamate receptor function spine morphology, but phenotypes are not universally penetrant, indicating other core facets...
Proteins of the ProSAP/Shank family act as major organizing scaffolding elements within postsynaptic density excitatory synapses. Deletions, mutations or downregulation these molecules has been linked to autism spectrum disorders, related Phelan McDermid Syndrome Alzheimer's disease. proteins are targeted synapses depending on binding zinc, which is a prerequisite for assembly scaffold. To gain insight into whether previously reported through zinc ions provides crossing point between genetic...
Neurodegenerative disorders (NDs) are conditions marked by progressively escalating inflammation that leads to the degeneration of neuronal structure and function. There is an increasing interest in natural compounds, especially those from pharmaceutical plants, with neuroprotective properties as part potential therapeutic interventions. Thus, rich bioactive content perennial herb rosemary (Rosmarinus officinalis) thoroughly reviewed this article, emphasis on its pleiotropic pharmacological...
Because evasion of apoptosis can cause radioresistance glioblastoma, there is a need to design rational strategies that counter resistance. In the present study, we investigated potential targeting antiapoptotic protein XIAP for radiosensitization glioblastoma. Here, report small-molecule inhibitors significantly enhance γ-irradiation-induced loss viability and cooperate with γ-irradiation suppress clonogenic survival glioblastoma cells. Analysis molecular mechanisms reveals act in concert...
Zn is essential for growth and development. The bioavailability of affected by several factors such as other food components. It therefore interest, to understand uptake mechanisms delivering compounds identify ways bypass the inhibitory effects these factors. Here, we studied effect amino acid conjugates (ZnAAs) on bioavailabilty Zn. We used Caco-2 cells enterocytes differentiated from human induced pluripotent stem a control Acrodermatitis enteropathica (AE) patient, performed fluorescence...
Autism spectrum disorders (ASD) are a group of neurodevelopmental characterized by deficits in social interaction and communication, repetitive behaviors. In addition, co-morbidities such as gastro-intestinal problems have frequently been reported. Mutations deletion proteins the SH3 multiple ankyrin repeat domains (SHANK) gene-family were identified patients with ASD, Shank knock-out mouse models display autism-like phenotypes. SHANK3 not only expressed central nervous system (CNS). Here,...
Zinc deficiency has recently been linked to the etiology of autism spectrum disorders (ASD) as environmental risk factor. With an estimated 17% world population being at zinc deficiency, especially during pregnancy might be a common occurrence, also in industrialized nations. On molecular level, shown affect signaling pathway glutamatergic synapses that previously identified through genetic mutations ASD patients, Neurexin-Neuroligin-Shank pathway, via altering binding Shank family members....
Zinc is an essential trace metal for bacteria of the intestinal flora. Approximately 20% dietary zinc - intake used by bacteria. The microbiome has recently been described as important factor healthy brain function via so-called gut-brain interactions. Similarly, deficiency associated with neurological problems such depression, mental lethargy and cognitive impairments in humans animal models. However, underlying pathomechanisms are currently not well understood a link between altered...
Abstract Background Pro-inflammatory processes triggered by the accumulation of extracellular amyloid beta (Aβ) peptides are a well-described pathology in Alzheimer's disease (AD). Activated astrocytes surrounding Aβ plaques contribute to inflammation secreting proinflammatory factors. While may phagocytize and clearance, reactive also increase production. Therefore, identifying factors that can attenuate astrocyte activation neuroinflammation how these influence pro-inflammatory pathways is...