A5076720573- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Hormonal Regulation and Hypertension
- Attention Deficit Hyperactivity Disorder
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Cannabis and Cannabinoid Research
- Adipose Tissue and Metabolism
- Gut microbiota and health
- Alcohol Consumption and Health Effects
- Cholesterol and Lipid Metabolism
- Religion, Spirituality, and Psychology
- Insect and Pesticide Research
- Digital Mental Health Interventions
- Forensic Toxicology and Drug Analysis
- Cognitive Functions and Memory
- Neural and Behavioral Psychology Studies
- Cellular transport and secretion
Institut de Neurosciences Cognitives et Intégratives d’Aquitaine
2011-2024
Centre National de la Recherche Scientifique
2006-2024
Université de Bordeaux
2006-2024
University of Coimbra
2024
University of Lausanne
2024
University of Bergen
2024
École Pratique des Hautes Études
2023-2024
Fraunhofer Institute for Interfacial Engineering and Biotechnology
2010
Institut de génétique et de biologie moléculaire et cellulaire
2010
Centre Léon Bérard
2010
Nicotine is the primary psychoactive component of tobacco. Its reinforcing and addictive properties depend on nicotinic acetylcholine receptors (nAChRs) located within mesolimbic axis originating in ventral tegmental area (VTA). The roles oligomeric assembly subunit α4- α6-containing nAChRs dopaminergic (DAergic) neurons are much debated. Using subunit-specific knockout mice targeted lentiviral re-expression, we have determined dependence intracranial nicotine self-administration (ICSA) into...
Chronic nicotine exposure results in long-term homeostatic regulation of nicotinic acetylcholine receptors (nAChRs) that play a key role the adaptative cellular processes leading to addiction. However, relative contribution different nAChR subunits this process is unclear. Using genetically modified mice and pharmacological manipulations, we provide behavioral, electrophysiological, evidence for mechanism by which chronic triggers opposing differentially mediated β2*- vs. α7*nAChRs. These...
The present study was aimed at determining the relative contribution of dorsal (DH) and ventral (VH) hippocampus in stress-induced memory retrieval impairments. Thus, we studied temporal involvement corticosterone its receptors, i.e. mineralocorticoid (MR) glucocorticoid (GR) DH VH, relation with time-course evolution In a first experiment, double microdialysis allowed showing on same animal that an acute stress (electric footshocks) induced earlier rise (15-60 min post-stress) then VH...
Exposure to prolonged, unpredictable stress leads glucocorticoids-mediated long-lasting neuroendocrine abnormalities associated with emotional and cognitive impairments. Excessive levels of serum glucocorticoids (cortisol in humans, corticosterone rodents) contribute notably deficits working memory (WM), a task which heavily relies on functional interactions between the medial prefrontal cortex (PFC) dorsal hippocampus (dHPC). However, it is unknown whether stress-induced increases plasma...
Abstract This study intends to determine whether long‐lasting glucocorticoids (GCs) dysregulation in the prefrontal cortex (PFC) or dorsal hippocampus (dHPC) play a causal role maintenance of working memory (WM) deficits observed after alcohol withdrawal. Here, we report that C57/BL6 male mice submitted 6 months consumption (12 percent v/v) followed by 1 (1W) weeks (6W) withdrawal periods exhibit WM spatial alternation task and an exaggerated corticosterone rise during testing PFC but not...
The multiple memory systems hypothesis posits that different neural circuits function in parallel and may compete for information processing storage. For example, instrumental conditioning would depend on the striatum, whereas spatial be mediated by a circuit centered hippocampus. However, nature of task itself is not sufficient to select durably one system over other. In this study, we investigated effects natural pharmacological rewards selection particular during learning. We compared...
A link between gut dysbiosis and the pathogenesis of brain disorders has been identified. role for bacteria in drug reward addiction suggested but very few studies have investigated their impact on behavioral responses to addictive drugs so far. In particular, influence nicotine's addiction-like processes remains unknown. addition, evidence shows that glial cells shape neuronal activity mesolimbic system regulation, within this system, by microbiome is not established. We demonstrate a lack...
Nicotine addiction, through smoking, is the principal cause of preventable mortality worldwide. Human genome-wide association studies have linked polymorphisms in CHRNA5-CHRNA3-CHRNB4 gene cluster, coding for α 5 , 3 and β4 nicotinic acetylcholine receptor (nAChR) subunits, to nicotine addiction. β4*nAChRs been implicated withdrawal, aversion, reinforcement. Here we show that also are involved non-nicotine-mediated responses may predispose addiction-related behaviors. knock-out (KO) male...
Abstract In order to study the functional role of trans‐synaptic neuronal interaction between glutamatergic afferents and mesolimbic dopaminergic neurons in internal reward processes, BALB/c male mice were unilaterally implanted with a guide‐cannula, tip which was positioned 1.5 mm above ventral tegmental area (VTA). On each day following experimental period, stainless steel injection cannula inserted into VTA eventual self‐administration behaviour either competitive N ‐methyl‐ d ‐aspartate...