A5045753951- Nicotinic Acetylcholine Receptors Study
- Smoking Behavior and Cessation
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Biochemical Analysis and Sensing Techniques
- Photoreceptor and optogenetics research
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Advanced Fluorescence Microscopy Techniques
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Zebrafish Biomedical Research Applications
- Neurobiology and Insect Physiology Research
- Stress Responses and Cortisol
- Nerve injury and regeneration
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
Université de Bordeaux
2009-2024
Neurocentre Magendie
2017-2024
Inserm
2009-2024
Corticosterone, the main glucorticoid hormone in rodents, facilitates behavioral responses to cocaine. Corticosterone is proposed modulate cocaine intravenous self-administration (SA) and cocaine-induced locomotion through distinct receptors, glucocorticoid receptor (GR) mineralocorticoid (MR), respectively. However, this remains debatable. On one hand, modulation of both by GR was tested different experimental conditions, i.e. light versus dark nycthemeral phase naïve cocaine-experienced...
Abstract The significant heterogeneity in smoking behavior among smokers, coupled with the inconsistent efficacy of approved cessation therapies, supports presence individual variations mechanisms underlying smoking. This emphasizes need to shift from standardized personalized therapies. However, informed precision medicine demands fundamental research. Tobacco is influenced and sustained by diverse psychopharmacological interactions between nicotine environmental stimuli. In classical...
Nicotine is acknowledged as the key addictive compound of tobacco. Varenicline (Champix® or Chantix®), mainly acting a partial agonist at α4β2 nicotinic receptor, an approved smoking cessation pharmacotherapy, although with efficacy limited to portion smokers. Smokers differ in motives that drive their drug seeking and might be more efficient some groups than others. Studies rodents revealed nicotine-seeking strongly supported by complex interactions between nicotine environmental cues,...
Despite the popularity of fiber photometry (FP), its integration with operant behavior paradigms is progressing slowly. This can be attributed to complex protocols in - resulting a combination diverse non-predictable behavioral responses and scheduled events, thereby complicating data analysis. To overcome this, we developed Pyfiber, an open-source python library which facilitates merge FP by relating changes fluorescent signals within neuronal population events. Pyfiber helps 1. Extract...
ABSTRACT Background Advances in vivo fluorescent imaging have exploded with the recent developments of genetically encoded calcium indicators (GECIs) and biosensors. Their use a bulk technique such as fiber photometry (FP) can be highly beneficial identifying neuronal signatures behavioral neuroscience experiments. Popularity FP has grown rapidly. Initially applied to classical conditioning, its integration into operant behavior paradigms is progressing. However, behavior, protocols complex...
Abstract The significant heterogeneity in smoking behavior among smokers, coupled with the inconsistent efficacy of approved cessation therapies, supports presence individual variations mechanisms underlying smoking. This emphasizes need to shift from standardized personalized therapies. However, informed precision medicine demands fundamental research. Tobacco is influenced and sustained by diverse psychopharmacological interactions between nicotine environmental stimuli. In classical...
A bstract Background Smokers vary in their motives for tobacco seeking, suggesting that they could benefit from personalized treatments. However, these variations have received little attention animal models the study of dependence. In most classically used model, ie. intravenous self-administration nicotine rat, seeking behaviour is reinforced by combination with a discrete stimulus (eg. cue light). both human and animals, two types psychopharmacological interactions between environmental...