A5045481396- Nicotinic Acetylcholine Receptors Study
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Philosophy, Sociology, Political Theory
- Psychotherapy Techniques and Applications
- Psychoanalysis and Psychopathology Research
Université Paris Cité
2015-2019
Délégation Paris 5
2019
Centre National de la Recherche Scientifique
2011-2017
Institut de Biologie Paris-Seine
2017
Neurosciences Paris-Seine
2015-2017
Sorbonne Université
2011-2017
Inserm
2015
Nicotine is the primary psychoactive component of tobacco. Its reinforcing and addictive properties depend on nicotinic acetylcholine receptors (nAChRs) located within mesolimbic axis originating in ventral tegmental area (VTA). The roles oligomeric assembly subunit α4- α6-containing nAChRs dopaminergic (DAergic) neurons are much debated. Using subunit-specific knockout mice targeted lentiviral re-expression, we have determined dependence intracranial nicotine self-administration (ICSA) into...
Addiction is a maladaptive pattern of behavior following repeated use reinforcing drugs in predisposed individuals, leading to lifelong changes. Common among these changes are alterations neurons releasing dopamine the ventral and dorsal territories striatum. The serotonin 5-HT 2B receptor has been involved various behaviors, including impulsivity, response antidepressants, psychostimulants, pointing toward putative interactions with system. Despite findings, it remains unknown whether...
Abstract Midbrain dopamine (DA) neurons are key players in motivation and reward processing. Increased DA release is thought to be central the initiation of drug addiction. Whereas generally considered activated by drugs such as nicotine, we report here that nicotine not only induces excitation ventral tegmental area (VTA) cells but also inhibition a subset VTA anatomically segregated medial part VTA. These opposite responses do correlate with induced noxious stimuli. We show this requires...