A5010568751- Personality Disorders and Psychopathology
- Psychotherapy Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Mental Health and Psychiatry
- Attention Deficit Hyperactivity Disorder
- Personality Traits and Psychology
- Mental Health Research Topics
- Autism Spectrum Disorder Research
- Neural and Behavioral Psychology Studies
- Action Observation and Synchronization
- Visual perception and processing mechanisms
- Multisensory perception and integration
- Motor Control and Adaptation
- Suicide and Self-Harm Studies
- Animal Genetics and Reproduction
- Color perception and design
- Digital Mental Health Interventions
- Behavioral Health and Interventions
- Bipolar Disorder and Treatment
- Olfactory and Sensory Function Studies
- Virology and Viral Diseases
- Education, Achievement, and Giftedness
- Genomics and Chromatin Dynamics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Genetics and Neurodevelopmental Disorders
University of Koblenz and Landau
2018-2024
Universität Koblenz
2018-2021
Heidelberg University
2013-2019
Central Institute of Mental Health
2012-2019
University Hospital Heidelberg
2013-2019
Western University
2018
Klinik für Psychosomatik
2015
University of Göttingen
2010-2012
Max Planck Institute of Experimental Medicine
2008-2009
Max Planck Society
2009
Autism spectrum conditions (ASCs) are heritable characterized by impaired reciprocal social interactions, deficits in language acquisition, and repetitive restricted behaviors interests. In addition to more complex genetic susceptibilities, even mutation of a single gene can lead ASC. Several such monogenic ASC forms caused loss-of-function mutations genes encoding regulators synapse function neurons, including NLGN4. We report that mice with the murine NLGN4 ortholog Nlgn4, which encodes...
Autism spectrum disorder (ASD) is a frequent neurodevelopmental characterized by variable clinical severity. Core symptoms are qualitatively impaired communication and social behavior, highly restricted interests repetitive behaviors. Although recent work on genetic mutations in ASD has shed light the pathophysiology of disease, classifying it essentially as synaptopathy, no treatments available to date. To develop test novel treatment approaches, validated informative animal models...
Patients with posttraumatic stress disorder (PTSD) are prone to dissociation, which in theory should interfere successful treatment. However, most empirical studies do not substantiate this assumption.The primary objective was test whether state dissociation predicts the success of an adaptation dialectical behavior therapy designed for treatment patients PTSD after childhood sexual abuse (CSA) (DBT-PTSD). We further explored operationalization as versus trait made a difference respect...
Previous research has suggested that patients meeting criteria for borderline personality disorder (BPD) display altered self-related information processing. However, experimental studies on dysfunctional self-referential processing in BPD are rare. In this study, (N = 30) and healthy control participants judged positive, neutral, negative words terms of emotional valence. Referential was manipulated by a preceding pronoun, an other-referential or no referential context. Subsequently,...
Borderline Personality Disorder (BPD) is characterized by affective instability, but self-injurious behavior appears to have an emotion-regulating effect. We investigated whether pain-mediated affect regulation can be altered at the neural level residential Dialectical Behavior Therapy (DBT), providing adaptive emotion techniques. Likewise, we pain thresholds or appraisal of change after psychotherapy. 28 patients with BPD undergoing DBT (self-referral), 15 treatment as usual and 23 healthy...
Affective hyper-reactivity and impaired cognitive control of emotional material are core features borderline personality disorder (BPD). A high percentage individuals with BPD experience stress-related dissociation, including numbing memory disruptions. So far little is known about how dissociation influences the neural processing in context a working task BPD. We aimed to investigate whole-brain activity amygdala functional connectivity (FC) during an Emotional Working Memory Task (EWMT)...
Abstract Introduction Individualized treatment prediction is crucial for the development and selection of personalized psychiatric interventions. Here, we use random forest classification via pretreatment clinical demographical (CD), functional, structural magnetic resonance imaging (MRI) data from patients with borderline personality disorder (BPD) to predict individual response. Methods Before dialectical behavior therapy (DBT), 31 female underwent functional (three different emotion...
There is increasing evidence that psychotherapy can alter the function of brain patients with borderline personality disorder (BPD). However, it not known whether also modify structure BPD.
Abstract Our objective is to implement a single-case experimental design (SCED) infrastructure in combination with experience-sampling methods (ESM) into the standard diagnostic procedure of German outpatient research and training clinic. Building on idea routine outcome monitoring, SCED introduces intensive longitudinal data collection, individual effectiveness measures, opportunity for systematic manipulation push personalization efforts further. It aims empower psychotherapists patients...
Patients with Borderline Personality Disorder (BPD) expect and perceive social rejection stronger than healthy individuals. Shifting ones attention from oneself to others has been suggested as a mechanism deal the experience of rejection. Here, we investigated whether BPD participants avoid increased self-awareness this is done intentionally.Thirty patients 30 control participants, all naïve study's purpose, were asked choose either seat facing mirror (self-awareness) or not (avoidance...
Implicit change detection demonstrates how the visual system can benefit from stored information that is not immediately available to conscious awareness. We investigated role of motor action in this context. In first two experiments, using a one-shot implicit change-detection paradigm, participants responded unperceived changes either with an (jabbing screen at guessed location change) or words (verbal report), and sat 60 cm 300 (with laser pointer) away display. Our observers locations...
In grapheme-color synesthesia, observers perceive colors that are associated with letters and numbers. We tested the dynamic limits of this phenomenon by exposing two synesthetes to characters rotate smoothly, morph into other characters, disappear abruptly, or have either consistent inconsistent corresponding synesthetic color. Rotating changed their abruptly as letter identification failed. Morphing also color together a change in identification. Abrupt disappearance black character on...
62 parents of gifted children completed the 16 Personality Factor Questionnaire. In comparison to general male population, fathers tended be more intelligent, independent, aloof, assertive, and tense. The mothers also intelligent independent but were conscientious, persistent, took a calculated controlled approach life than female population. As combined group, found likely stand by their own ideas, self-controlled, persistent