A5024306544- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Parkinson's Disease Mechanisms and Treatments
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Metabolism and Genetic Disorders
- Pelvic floor disorders treatments
- Retinal Development and Disorders
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cytomegalovirus and herpesvirus research
- Caveolin-1 and cellular processes
- Protein Degradation and Inhibitors
- Photoreceptor and optogenetics research
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- Galectins and Cancer Biology
- Folate and B Vitamins Research
- Sirtuins and Resveratrol in Medicine
- Extracellular vesicles in disease
- CRISPR and Genetic Engineering
- Protein Kinase Regulation and GTPase Signaling
- Nutrition and Health in Aging
Nanjing Maternity and Child Health Care Hospital
2019-2024
Nanjing Medical University
2019-2024
Simcere Pharmaceutical (China)
2020
Huashan Hospital
2016-2018
Fudan University
2010-2018
Nanjing University
2014-2017
Nanjing University of Chinese Medicine
2017
State Key Laboratory of Medical Neurobiology
2016
Jiangsu Province Hospital
2014
Nanjing Traditional Chinese Medicine Hospital
2014
Although tumor-infiltrating lymphocytes (TILs) maintain their ability to proliferate, persist, and eradicate tumors, they are frequently dysfunctional in situ. By performing both whole-genome CRISPR metabolic inhibitor screens, we identify that nicotinamide phosphoribosyltransferase (NAMPT) is required for T cell activation. NAMPT low TILs, its expression controlled by the transcriptional factor Tubby (TUB), whose activity depends on receptor-phospholipase C gamma (TCR-PLCγ) signaling axis....
Extracellular vesicles (EVs) have the potential to be utilized as disease-specific biomarkers. Although strategies for on-chip isolation and detection of EVs recently been developed, they need preprocessing clinical samples are not accurate enough disease diagnosis just judging by concentration. Here, we designed an integrated microfluidic device named a plasma separation EV (PS-ED) chip separation, quantification, high-throughput protein analysis directly from whole blood samples. The...
Endometrial cancer (EC) is the most common gynecological malignancy worldwide. However, molecular mechanisms underlying EC progression are still largely unknown, and chemotherapeutic options for patients currently very limited. In this study, we found that histone methyltransferase EZH2 DNA DNMT3B were upregulated in samples from patients, promoted cell proliferation as evidenced by assays of viability, cycle, colony formation. Mechanistically, epigenetically repressing TCF3, a direct...
Abstract Introduction Numerous studies have been carried out to explore the potential association between neurologic deficits and variable clinical manifestations of Parkinson's disease ( PD ). The aim our study was investigate cognitive performance motor dysfunction in Chinese patients with . Methods Data from 96 were obtained patient cohort database Huashan Hospital. All participants underwent a comprehensive neuropsychological evaluation assess status, that included scoring on Mini‐mental...
Ovarian cancer (OC) is the most fatal gynaecological malignancy and has a poor prognosis. Glycosylation, biosynthetic process that depends on specific glycosyltransferases (GTs), recently attracted increasing importance due to vital role it plays in cancer. In this study, we aimed determine whether OC patients could be stratified by glycosyltransferase gene profiles better predict prognosis efficiency of immune checkpoint blockade therapies (ICBs).We retrieved transcriptome data across 420...
Multiple cell death is involved in ischemic brain injury. Necroptosis, a recently reported death, may be the most suitable mechanism subpopulation of neurons under It that small molecule, necrostatin-1 (Nec-1), has potent inhibitory effect on necroptotic vivo and vitro. The aim current study was to investigate role Nec-1 cognitive function chronic stroke mice induced by bilateral common carotid artery stenosis (BCAS). Here, 12-week-old C57BL/6 received intragastric administration with or...
Parkinson's disease is characterized by motor and non-motor symptoms with wide ranging impacts on the health-related quality of life. The 39-item Questionnaire (PDQ-39) most widely used PD-specific quality-of-life questionnaire. short-form 8-item (PDQ-8) was found to produce results similar that PDQ-39 cross-culturally. However, there no evaluation PDQ-8 in mainland China. In this longitudinal study, 283 patients were recruited. PDQ-39, other scales administered. Patients attended clinic...
Tyrosine phosphorylation, orchestrated by tyrosine kinases and phosphatases, modulates a multi-layered signaling network in time- space-dependent manner. Dysregulation of this post-translational modification is inevitably associated with pathological diseases. Our previous work has demonstrated that non-receptor kinase FER upregulated ovarian cancer, knocking down which attenuates metastatic phenotypes. However, due to the limited number known substrates cancer context, molecular basis for...
Stereotactic radiosurgery (SRS), such as body gamma knife, was reported to achieve excellent rates of local disease control with limited toxicity in many cases primary or secondary pulmonary tumor, except osteosarcoma. To confirm the value SRS metastases from osteosarcoma, we reviewed experience our institution (Department Oncology, Affiliated Sixth People's Hospital, Shanghai) and compared efficiency that surgical resection. From January 2005 December 2012, carried out a retrospective...
Cervical cancer (CC) is one of the most common malignant tumors in women, and its treatment often accompanied by high recurrence. We aimed to identify long non-coding RNAs (lncRNAs) associated with CC recurrence.We downloaded lncRNAs expression data patients from The Cancer Genome Atlas (TCGA) dataset used Cox regression models analyze relationship significantly were utilized construct a recurrence risk score (RRS) model. Bioinformatics analyses assess potential role critical effect on...
Aberrant overexpression of nonreceptor tyrosine kinase FER (Fps/Fes Related) has been reported in various ovarian carcinoma–derived tumor cells and is a poor prognosis factor for patient survival. It plays an essential role cell migration invasion, acting concurrently both kinase-dependent -independent manners, which not easily suppressed by conventional enzymatic inhibitors. Nevertheless, the PROteolysis-TArgeting Chimera (PROTAC) technology offers superior efficacy over traditional...
Abstract Background Olfactory identification was reported to be better among PD (Parkinson disease) patients with Parkin mutations, but previous studies didn't eliminate the interference of other related genes on olfaction, and whether olfaction mutations in Chinese population still unknown. Objective To assess function population. Materials Methods A total 226 a positive family history or an early‐onset age (<50 years) were enrolled for genetic testing by target sequencing multiple...
Perrault syndrome is a rare multisystem disorder that manifests with sensorineural hearing loss in both sexes, primary ovarian insufficiency females and neurological features. The heterogeneous genetically phenotypically. We reported consanguineous family (two affected sisters) syndrome. proband had the characteristics of syndrome: dysgenesis, bilateral obvious signs. Target genetic sequencing triplet repeat primed PCR (TP-PCR) plus capillary electrophoresis was conducted to detect causative...
The aim of the present study was to investigate imaging characteristics ovarian fibrothecoma. cases 25 female patients with pathologically confirmed fibrothecomas were retrospectively reviewed. Tumor location, size, density, signal intensity, cystic degeneration, calcification, enhancement pattern and ascites assessed by computed tomography (CT) (n=20) magnetic resonance (MRI) (n=5). Clinical histological features also evaluated. results revealed that 23 (92.0%) postmenopausal, a mean age ±...
// Jing Han 1, 2 , Zhou 3 Hua Yuan 4 Longbiao Zhu Hongxia Ma Dong Hang Dake Li 5 1 Department of Epidemiology and Biostatistics, School Public Health, Nanjing Medical University, 211166, China Epidemiology, University Affiliated Cancer Institute Jiangsu Province, State Key Laboratory Reproductive Medicine, Jangsu Oral Disease, 210029, Gynaecology, Provincial Hospital TCM, 210005, Correspondence to: Hang, email: hangdong@njmu.edu.cn Li, lidake2002@163.com Keywords: ovarian cancer, Chinese...
Abstract Background Although high‐risk human papillomavirus (HR‐HPV) infection is recognized as the main cause of cervical cancer, only a minority HPV‐infected women develop this malignancy. Increasing evidence suggests that alterations telomere length might be implicated in carcinogenesis. However, association between cancer and remains unknown. Methods This case‐control study included 591 patients 373 cancer‐free controls, all whom were infected with HR‐HPV. Relative (RTL) exfoliated cells...