A5076459490- Mycobacterium research and diagnosis
- Leprosy Research and Treatment
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Infectious Diseases and Mycology
- Ocular Diseases and Behçet’s Syndrome
- Autoimmune Bullous Skin Diseases
- Radiation Dose and Imaging
- Magnetic and Electromagnetic Effects
- Drug-Induced Adverse Reactions
- Autophagy in Disease and Therapy
- Autoimmune and Inflammatory Disorders
- Cytomegalovirus and herpesvirus research
- Water Quality Monitoring Technologies
- Biosensors and Analytical Detection
- Connexins and lens biology
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Skin Protection and Aging
- Radioactivity and Radon Measurements
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- Advanced Photocatalysis Techniques
- Studies on Chitinases and Chitosanases
- Calcium Carbonate Crystallization and Inhibition
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Chinese Academy of Medical Sciences Dermatology Hospital
2018-2025
Institute of Dermatology
2018-2025
Nanjing Medical University
2019-2025
Chinese Center For Disease Control and Prevention
2022-2024
Zhongyuan University of Technology
2023-2024
Peking Union Medical College Hospital
2022-2024
Southwest University
2022-2023
Center for Disease Control
2023
National Center for AIDS/STD Control and Prevention,China CDC
2019-2022
A cohort study was conducted to investigate the relation between cancer incidence and occupational exposure ionizing radiation. Records containing dose information from 1951 1988 for 191,333 persons were extracted National Dose Registry of Canada. The records linked Canadian Cancer Data Base, with data 1969 1988. Standardized ratios calculated using rates stratified by age, sex, calendar year. Excess relative risks obtained internally based dose-response analyses. following significant...
Previous studies have suggested that a single dose of rifampin has protective effects against leprosy in close contacts patients with the disease. Rifapentine was shown to greater bactericidal activity Mycobacterium leprae than murine models leprosy, but data regarding its effectiveness preventing are lacking. Download PDF Research Summary. We conducted cluster-randomized, controlled trial investigate whether single-dose rifapentine is effective household leprosy. The clusters (counties or...
A cohort mortality study of occupational radiation exposure was conducted using the records National Dose Registry Canada. The consisted 206,620 individuals monitored for between 1951 and 1983 with follow-up through December 31, 1987. total 5,426 deaths were identified by computerized record linkage Canadian Mortality Data Base. standardized ratio all causes death 0.61 both sexes combined. However, trends increasing cumulative to whole body noted in males females. In males, cancer appeared...
Endometrial cancer (EC) is the most common gynecological malignancy worldwide. However, molecular mechanisms underlying EC progression are still largely unknown, and chemotherapeutic options for patients currently very limited. In this study, we found that histone methyltransferase EZH2 DNA DNMT3B were upregulated in samples from patients, promoted cell proliferation as evidenced by assays of viability, cycle, colony formation. Mechanistically, epigenetically repressing TCF3, a direct...
With the prevalence of leprosy dramatically declining, focus control has gradually shifted from implementation multidrug therapy (MDT) to accelerating reduction disease burden and preventing disability. Southwestern China currently bears highest in more than half disability cases reported every year are this region. However, potential risk factors area remain unknown. In study, we evaluated physical disabilities 4578 patients southwest 2010 2020. Clinical epidemiological associated with...
Interferon-induced protein 44-like (IFI44L) gene is a type I interferon-stimulated (ISG) that plays critical role in antiviral activity and constitutes promising diagnostic marker. However, its precise function tuberculosis have not been unveiled. This study showed IFI44L acts as an antimicrobial target positive modulator human macrophages. Knockdown of led to increased Mycobacterium intracellular survival. Moreover, was significantly upregulated, it restricted the survival M. H37Rv strains...
Severe cutaneous adverse drug reactions (SCARs) are a group of serious clinical conditions caused by immune reaction to certain drugs. The allelic variance human leukocyte antigens HLA-B*13:01 has been strongly associated with hypersensitivities induced dapsone (DDS). T-cell receptor mediated activation cytotoxic T lymphocytes (CTLs) also suggested play an essential role in pathogenesis SCARs. However, HLA-B*13:01-DDS-TCR synapse that plays drug-induced hypersensitivity syndrome (DIHS) cells...
The present study analyzed the impact of COVID-19 pandemic on prevalence and incidence new leprosy cases, as well diversity, distribution, temporal transmission Mycobacterium leprae strains at county level in leprae-endemic provinces Southwest China. A total 219 cases during two periods, 2018-2019 2020-2021, were compared. We genetically characterized 83 clinical isolates M. Guizhou using variable number tandem repeats (VNTRs) single nucleotide polymorphisms (SNPs). obtained genetic profiles...
Abstract More than 100 counties, mainly in southwest China, report incidence rates of leprosy >1/100,000. The current study analysed the epidemiology China to improve our understanding transmission pattern and control programs. 207 counties were selected China. Leprosy patients their household contacts recruited. data from medical interview serological antileprosy antibody analysed. A total 2,353 new cases interviewed. distribution was partly associated with local natural economic...
Cutaneous tuberculosis with various manifestations can be divided into several clinical types according to the host's immune status and infective route. However, etiological factors of this disease remain unclear. The objective study is investigate pathogens associated occurrence different cutaneous tuberculosis. 58 Mycobacterium strains isolated from over last 20 years were sequenced analyzed for genomic characteristics including lineage distribution, drug-resistance mutations, mutations...
Abstract Background Despite many efforts to control leprosy worldwide, it is still a significant public health problem in low- and middle-income regions. It has been endemic China for thousands of years, southwest the highest burden country. Methods This observational study was conducted with all newly detected cases from 2010 2020. Data were extracted Leprosy Management Information System (LEPMIS) database China. The Joinpoint model used determine time trends area. Spatial autocorrelation...
In this study, a circulating water experimental system was constructed to investigate the scale inhibition, removal, corrosion and disinfection effects of industrial under combined action electromagnetic electrochemical fields. The influence these on quality parameters their inhibition hanging plate experiments were examined. Qualitative quantitative analyses samples conducted using XRD (X-ray diffraction) SEM (scanning electron microscopy), along with evaluation changes in (such as...
Reports on antimicrobial resistance (AMR) of Mycobacterium leprae, relationship with bacteriological index (BI), and transmission in China are limited. We investigated the emergence AMR mutations, between BI complete, moderate lack decline cases, molecular epidemiological features cases by enrolling 290 leprosy from four endemic provinces. Seven (2.41%), one (0.34%), five (1.72%), (0.34%) strains had single mutations folP1, rpoC, gyrA, gyrB, 23S rRNA, respectively. Double folP1 rpoB gyrA...
Culture of Mycobacterium marinum is very time-consuming, taking several weeks to produce positive results. Seeking rapid and sensitive diagnostic methods for diagnosis can greatly improve patient treatment. Our study aimed compare the abilities polymerase chain reaction (PCR), nested PCR loop mediated isothermal amplification (LAMP) detecting M. in skin samples from patients with infection.A total 6 strains definite infection were included study. We optimized LAMP performance detection...
Skin and soft tissue infections caused by rapidly growing non-tuberculous mycobacteria (RG-NTM) have become a clinical concern over the past decades. These RG-NTM are ubiquitous environmental organisms most resistant to traditional antituberculous agents. In this report, we describe 3 cutaneous RG-NTM, namely, Mycobacterium abscessus, M. chelonae, conceptionense, present laboratory characteristics of these infections.
Understanding the nature of Mycobacterium leprae transmission is vital to implement better control strategies for leprosy elimination. The present study expands knowledge county-level strain diversity, distribution, and patterns in endemic provinces China.We genetically characterized 290 clinical isolates M. from four using variable number tandem repeats (VNTR) single nucleotide polymorphisms (SNPs). Attained genetic profiles cluster consequences were contrasted with geographical migration...
The diagnosis of paucibacillary (PB) leprosy often possesses a diagnostic challenge, especially for pure neuritic and lesser skin lesions with the zero bacillary load, requiring sensitive accurate tool. We have included 300 clinically diagnosed new cases (comprising 98 PB cases) analyzed sensitivity specificity by nested PCR folP , gyrA rpoB RLEP 16SrRNA Enzyme-linked Immunospot Assay test (ELISPOT) MMPII, NDO-BSA, LID-1 antigens detecting interferon gamma (IFN-γ) release. overall positivity...
Trichloroethylene (TCE)-induced hypersensitivity syndrome (THS) has been a concern for many researchers in the field of environmental and occupational health. Currently, there is no specific treatment THS, leaving patients to contend with severe infections arising from extensive skin lesions, consequently leading serious adverse effects. However, pathogenesis damage THS remains unclear. This study aims investigate danger signals mechanisms underlying through vivo vitro experiments. We...
Electrochemical descaling devices have been widely used in the industrial field due to their broad applicability, convenience of operation, and cost-effectiveness. However, there are many factors that affect performance electrochemical devices, such as selection electrode materials, shape layout anode cathode, voltage current equipment, flow rate, temperature, mineral content. Existing research has primarily focused on influence materials density efficiency, while neglecting external water...