A5100773094- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Leprosy Research and Treatment
- Infectious Diseases and Tuberculosis
- Infectious Diseases and Mycology
- Advanced Computational Techniques and Applications
- Fungal Infections and Studies
- Natural Language Processing Techniques
- Service-Oriented Architecture and Web Services
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders
- Drug-Induced Adverse Reactions
- Autoimmune Bullous Skin Diseases
- Semantic Web and Ontologies
- Immunodeficiency and Autoimmune Disorders
- Urticaria and Related Conditions
- Pharmacological Effects of Natural Compounds
- Cancer and Skin Lesions
- Ocular Diseases and Behçet’s Syndrome
- Immune Cell Function and Interaction
- Crystallization and Solubility Studies
- T-cell and B-cell Immunology
- Cutaneous lymphoproliferative disorders research
- X-ray Diffraction in Crystallography
- Acute Lymphoblastic Leukemia research
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Institute of Dermatology
2013-2025
Nanjing Medical University
2019-2025
Chinese Academy of Medical Sciences Dermatology Hospital
2013-2025
Tianjin Geothermal Exploration, Development and Design Institute (China)
2025
Donghua University
2024
Institute of Hematology & Blood Diseases Hospital
2024
Qingdao University
2024
Yuhuangding Hospital
2013-2024
Peking Union Medical College Hospital
2013-2024
Previous studies have suggested that a single dose of rifampin has protective effects against leprosy in close contacts patients with the disease. Rifapentine was shown to greater bactericidal activity Mycobacterium leprae than murine models leprosy, but data regarding its effectiveness preventing are lacking. Download PDF Research Summary. We conducted cluster-randomized, controlled trial investigate whether single-dose rifapentine is effective household leprosy. The clusters (counties or...
There is anatomical and functional connectivity between the primary motor cortex (M1) posterior parietal (PPC) that plays a role in sensorimotor integration. In this study, we applied corticocortical paired-associative stimuli to ipsilateral PPC M1 (parietal ccPAS) healthy right-handed subjects test if procedure could modulate excitability PPC-M1 connectivity. One hundred eighty paired transcranial magnetic at an interstimulus interval (ISI) of 8 ms were delivered 0.2 Hz. We found ccPAS left...
Technological advances in passive digital phenotyping present the opportunity to quantify neurological diseases using new approaches that may complement clinical assessments. Here, we studied multiple sclerosis (MS) as a model disease for investigating physiometric and environmental signals. The objective of this study was assess feasibility correlation wearable biosensors with traditional measures disability both clinic free-living MS patients. This is single site observational cohort...
Abstract Cushing’s syndrome is caused by an elevation of endogenous or pharmacologically administered glucocorticoids. Acyl coenzyme A binding protein (ACBP, encoded the gene diazepam inhibitor, Dbi ) stimulates food intake and lipo-anabolic reactions. Here we found that plasma ACBP/DBI concentrations were elevated in patients mice with syndrome. We used several methods for inhibition mice, namely, (1) induction autoantibodies, (2) injection a neutralizing monoclonal antibody, (3) body-wide...
Accurate prediction of PM2.5 (particle pollution from fine particulate) concentration is crucial for environmental protection and public health. Precipitable water vapor (PWV) in the atmosphere an important meteorological element with stratification properties, which plays a role energy transfer, weather dynamics, generation. However, past studies tend to use total PWV as input parameter, neglecting impact variations different altitude layers on concentration. To overcome this limitation,...
With the prevalence of leprosy dramatically declining, focus control has gradually shifted from implementation multidrug therapy (MDT) to accelerating reduction disease burden and preventing disability. Southwestern China currently bears highest in more than half disability cases reported every year are this region. However, potential risk factors area remain unknown. In study, we evaluated physical disabilities 4578 patients southwest 2010 2020. Clinical epidemiological associated with...
To identify the microorganism distribution clinical characteristics and management of cutaneous Mycobacterium tuberculosis nontuberculous mycobacterial infectious diseases in past 10 years we collected analyzed patient records all M. infection cases diagnosed by culture and/or PCR from 2008 to 2017 Hospital Dermatology Chinese Academy Medical Sciences. Among 203 including 89 infections 114 was most common species patients marinum predominated among followed abscessus. Cases especially...
Interferon-induced protein 44-like (IFI44L) gene is a type I interferon-stimulated (ISG) that plays critical role in antiviral activity and constitutes promising diagnostic marker. However, its precise function tuberculosis have not been unveiled. This study showed IFI44L acts as an antimicrobial target positive modulator human macrophages. Knockdown of led to increased Mycobacterium intracellular survival. Moreover, was significantly upregulated, it restricted the survival M. H37Rv strains...
Severe cutaneous adverse drug reactions (SCARs) are a group of serious clinical conditions caused by immune reaction to certain drugs. The allelic variance human leukocyte antigens HLA-B*13:01 has been strongly associated with hypersensitivities induced dapsone (DDS). T-cell receptor mediated activation cytotoxic T lymphocytes (CTLs) also suggested play an essential role in pathogenesis SCARs. However, HLA-B*13:01-DDS-TCR synapse that plays drug-induced hypersensitivity syndrome (DIHS) cells...
The present study analyzed the impact of COVID-19 pandemic on prevalence and incidence new leprosy cases, as well diversity, distribution, temporal transmission Mycobacterium leprae strains at county level in leprae-endemic provinces Southwest China. A total 219 cases during two periods, 2018-2019 2020-2021, were compared. We genetically characterized 83 clinical isolates M. Guizhou using variable number tandem repeats (VNTRs) single nucleotide polymorphisms (SNPs). obtained genetic profiles...
Background. Psoriasis, a systemic disorder mediated by the immune system, can appear on skin, joints, or both. Individuals with cutaneous psoriasis (PsC) have an elevated risk of developing psoriatic arthritis (PsA) during their lifetime. Despite this known association, cellular and molecular mechanisms underlying progression remain unclear. Methods. We performed high-dimensional, in-depth immunophenotyping peripheral blood mononuclear cells (PBMCs) in patients PsA vulgaris (PsV) mass...
Abstract More than 100 counties, mainly in southwest China, report incidence rates of leprosy >1/100,000. The current study analysed the epidemiology China to improve our understanding transmission pattern and control programs. 207 counties were selected China. Leprosy patients their household contacts recruited. data from medical interview serological antileprosy antibody analysed. A total 2,353 new cases interviewed. distribution was partly associated with local natural economic...
Cutaneous tuberculosis with various manifestations can be divided into several clinical types according to the host's immune status and infective route. However, etiological factors of this disease remain unclear. The objective study is investigate pathogens associated occurrence different cutaneous tuberculosis. 58 Mycobacterium strains isolated from over last 20 years were sequenced analyzed for genomic characteristics including lineage distribution, drug-resistance mutations, mutations...
Leprosy is a contagious and chronic systemic granulomatous disease caused by Mycobacterium leprae. In the pathogenesis of leprosy, granulomas play key role, however, mechanisms formation maintenance M. leprae are still not clearly understood.To better understand molecular physiology interaction between bacilli human host cells, we developed an in vitro model granulomas, which mimicked vivo leprosy. Macrophages were differentiated from monocytes, infected with leprae, then cultured autologous...
Abstract Background Despite many efforts to control leprosy worldwide, it is still a significant public health problem in low- and middle-income regions. It has been endemic China for thousands of years, southwest the highest burden country. Methods This observational study was conducted with all newly detected cases from 2010 2020. Data were extracted Leprosy Management Information System (LEPMIS) database China. The Joinpoint model used determine time trends area. Spatial autocorrelation...
Reports on antimicrobial resistance (AMR) of Mycobacterium leprae, relationship with bacteriological index (BI), and transmission in China are limited. We investigated the emergence AMR mutations, between BI complete, moderate lack decline cases, molecular epidemiological features cases by enrolling 290 leprosy from four endemic provinces. Seven (2.41%), one (0.34%), five (1.72%), (0.34%) strains had single mutations folP1, rpoC, gyrA, gyrB, 23S rRNA, respectively. Double folP1 rpoB gyrA...