A5020320910- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Ocular Surface and Contact Lens
- Contact Dermatitis and Allergies
- Immune Response and Inflammation
- Autoimmune Bullous Skin Diseases
- Mast cells and histamine
- Corneal Surgery and Treatments
- Asthma and respiratory diseases
- NF-κB Signaling Pathways
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Glaucoma and retinal disorders
- Inflammatory mediators and NSAID effects
- Immunodeficiency and Autoimmune Disorders
- Ocular Infections and Treatments
- Corneal surgery and disorders
- Immunotherapy and Immune Responses
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pediatric health and respiratory diseases
- Ocular Diseases and Behçet’s Syndrome
- interferon and immune responses
- Eosinophilic Disorders and Syndromes
Kyoto Prefectural University of Medicine
2016-2025
The University of Tokyo
2015-2017
Doshisha University
2008-2016
Ministry of Education, Culture, Sports, Science and Technology
2012
Ministry of Health Labour and Welfare
2012
National Institute of Health Sciences
2008
Osaka University
2002-2006
Tokyo University of Science
2004
Introduction: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 HLA-B*5801 with carbamazepine- allopurinol-induced reactions were found in Han Chinese patients, respectively, ethnic differences the have been reported. The objective this study is to clarify involvement Japanese SJS/TEN patients. Methods: HLA-B genotyping was performed on 58 patients between July 2006...
Summary Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life‐threatening severe cutaneous adverse reactions. Recently, strong associations of HLA‐B*1502 with carbamazepine‐induced SJS/TEN have been found in Han Chinese patients. These confirmed several Asian populations, excluding Japanese. SJS patients carrying HLA‐B*1508, HLA‐B*1511, or HLA‐B*1521, which members the HLA‐B75 type along HLA‐B*1502, were detected studies India Thailand. In current study, we...
Abstract Epithelial cells are key players in the first line of defense offered by mucosal immune system against invading pathogens. In present study we sought to determine whether human corneal epithelial expressing Toll-like receptors (TLRs) function as pattern-recognition innate and, if so, these TLRs act a ocular immunity. Incubation primary and cell (HCE-T) with peptidoglycan or LPS did not lead activation, at level DNA transcription, NF-κB secretion inflammation-associated molecules...
ABSTRACT Vibrio parahaemolyticus , a gram-negative marine bacterium, is an important pathogen causing food-borne gastroenteritis or septicemia. Recent genome sequencing of the RIMD2210633 strain (a Kanagawa phenomenon-positive clinical isolate serotype O3:K6) revealed that has two sets gene clusters encode type III secretion system (TTSS) apparatus. The first cluster, TTSS1, located on large chromosome, and second, TTSS2, small chromosome. Previously, we reported TTSS1 involved in...
The combination of allograft limbal transplantation (ALT) and amniotic membrane (AMT) has been applied in the treatment severe ocular surface diseases. beneficial effect this thought to result from possible immunosuppressive ability (AM). However, mechanisms any such remain unknown. In study, we investigated whether human AM suppress allo-reactive T cell responses vitro. For mixed lymphocyte reaction (MLR), lymphocytes isolated lymph nodes C57BL/6 mice (Mls1b, Vbeta6+) were cultured with...
<b>Background and aim:</b> Stevens–Johnson syndrome (SJS) toxic epidermal necrolysis (TEN) are acute-onset mucocutaneous diseases induced by infectious agents and/or inciting drugs. Given the association between onset of SJS/TEN infections, possibility that there is an a disordered innate immune response was considered. The first line defence against infection comprised evolutionarily conserved sets molecules, Toll–like receptors (TLRs). TLR3 recognises double-stranded RNA associated with...
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs (NSAIDs) multi-ingredient cold medications reported to be important inciting drugs. We used two sample sets Japanese patients investigate association between HLA genotypes medicine-related SJS/TEN (CM-SJS/TEN), acetaminophen-related (AR-SJS/TEN) with mucosal...
To assess the clinical efficacy of cultivated oral mucosal epithelial transplantation (COMET) for treatment persistent defect (PED).We treated 10 eyes nine patients with PED (Stevens-Johnson syndrome: three eyes; thermal/chemical injury: five ocular cicatricial pemphigoid: two eyes) COMET at Kyoto Prefectural University Medicine, Kyoto, Japan from 2002 to 2008.Preoperatively, existed on over more than 50% corneal surface in seven eyes. Severe inflammation fibrovascular tissue surrounded all...
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs multi-ingredient cold medications reported to be important inciting drugs. Recently, we that medicine related SJS/TEN (CM-SJS/TEN) with mucosal involvement ocular surface complications (SOC) is associated HLA-A*02:06 HLA-B*44:03 in Japanese. In this study,...