A5006209686- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Drug-Induced Adverse Reactions
- Skin Protection and Aging
- Contact Dermatitis and Allergies
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Advanced Glycation End Products research
- Ocular Infections and Treatments
- Mast cells and histamine
- Salivary Gland Disorders and Functions
- Retinal Diseases and Treatments
- Ergonomics and Musculoskeletal Disorders
- Immunodeficiency and Autoimmune Disorders
- melanin and skin pigmentation
- Intraocular Surgery and Lenses
- Biochemical effects in animals
- Autoimmune Bullous Skin Diseases
- Cerebral Venous Sinus Thrombosis
- Retinal and Optic Conditions
- Dermatology and Skin Diseases
- Ophthalmology and Visual Impairment Studies
- Ocular Diseases and Behçet’s Syndrome
Universidade Federal de São Paulo
2014-2024
Hospital São Paulo
2024
Carl Zeiss (Germany)
2022
Oculus Optikgeräte (Germany)
2022
Universidade Federal do ABC
2022
Hospital do Servidor Público Estadual
2022
University of Liverpool
2022
Universidade Federal do Espírito Santo
2022
Brazilian Academy of Sciences
2022
Universidade Federal do Rio de Janeiro
2022
We evaluated the levels of lipid oxidative stress markers and inflammatory cells from tears conjunctiva patients with Sjögren syndrome (SS) normal subjects.We examined 31 eyes 16 (16 females) SS 15 10 healthy controls (2 males 8 in this prospective study. All subjects underwent a Schirmer test, measurement tear film break-up time, vital stainings, confocal microscopy conjunctiva, collection for hexanoyl-lysine (HEL), ELISA, conjunctival brush cytology. Brush cytology samples...
Purpose.: To demonstrate the conjunctival alterations in patients with Sjögren's (SSDE) and non-Sjögren's syndrome dry eye (NSSDE) using a new generation confocal microscope (HRTII/ RCM; Heidelberg Engineering, Heidelberg, Germany), prospective controlled study. Methods.: Twenty-eight right eyes of 28 SSDE (28 women; mean age, 58.2 ± 14.3 years), 7 NSSDE (7 66.1 14.4 14 age- sex-matched control subjects were studied. All underwent Schirmer test, tear film breakup time (BUT), vital staining,...
Purpose The purpose of our study was to investigate alterations in the meibomian gland (MG) Cu, Zn-Superoxide Dismutase-1 knockout (Sod1−/−) mouse. Methods Tear function tests [Break up time (BUT) and cotton thread] ocular vital staining test were performed on Sod1−/− male mice (n = 24) aged 10 50 weeks, age sex matched wild–type (+/+) 25). serum samples collected at sacrifice for inflammatory cytokine assays. MG specimens underwent Hematoxylin Eosin staining, Mallory fibrosis, Oil Red O...
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs multi-ingredient cold medications reported to be important inciting drugs. Recently, we that medicine related SJS/TEN (CM-SJS/TEN) with mucosal involvement ocular surface complications (SOC) is associated HLA-A*02:06 HLA-B*44:03 in Japanese. In this study,...
Purpose.: To prospectively evaluate the effect of controlled adverse chamber environment (CACE) exposure on tear function, including osmolarity, in subjects wearing narafilcon A versus those etafilcon soft contact lens (SCL). Methods.: Thirty-one healthy with no history wear (13 women, 18 men; average age, 30.5 ± 6.5 years) were randomly divided into age- and sex-matched groups (15 SCL; 16 SCL) entered a CACE for 20 minutes. All underwent evaporation rate, strip meniscometry, film breakup...
PURPOSETo assess the effectiveness of topical and subconjunctival bevacizumab in suppressing vascularization graft host bed following high-risk corneal transplantation.DESIGNSecondary analysis prospective, randomized, double-blind, placebo-controlled multi-centric clinical trial.PARTICIPANTSThe study includes patients over 18 years old who underwent penetrating keratoplasty, which was defined as 1 or more quadrants excluding limbus.MethodsPatients were randomized to treatment control groups....
Purpose. To investigate the status of oxidative stress and histopathologic alterations in patients with conjunctivochalasis compare findings those healthy control subjects. Methods. Eleven (n = 20 eyes) Yokoi grade 3 11 health subjects 22 were prospectively recruited. ELISA for tear hexanoyl-lysine (HEL) inflammatory cytokines, film break-up time tests, Schirmer test measurements, fluorescein rose bengal vital staining performed. Conjunctival specimens obtained during surgery cataract...
To evaluate the specificity and sensitivity of strip meniscometry (SM) testing in conjunction with tear function tests diagnosis dry eye (DE) disease to investigate effect SM on reflex tearing.One hundred seven left eyes 107 patients definite DE according Japanese diagnostic criteria 68 age- sex-matched control subjects were studied. Tear meniscus height (TMH) measurements, fluorescein film break-up time (FTBUT), (F) rose bengal (RB) staining, Schirmer's test-1 (ST) also performed. The...
Purpose Dry eye is a common, complex, and multifactorial disease of the ocular surface tear film that results in discomfort visual disturbances. Prevalence rates vary largely rely on studies involving older populations. This study sought to evaluate dry among sample young students Brazil. Methods Cross-sectional survey included 2,140 using 2 self-applicable questionnaires symptoms: Ocular Surface Disease Index (OSDI) Women’s Health Study (WHS) questionnaire list risk factors associated with...
Purpose: To evaluate the efficacy and safety of intense pulsed light (IPL) combined with meibomian gland expression (MGX) for treatment dry eye disease dysfunction associated chronic Stevens–Johnson syndrome toxic epidermal necrolysis. Methods: This prospective noncomparative interventional study included 29 patients (58 eyes) who underwent 3 sessions IPL MGX at 2-week intervals. Subjective symptoms (ocular surface index score) objective tests: matrix metalloproteinase 9, tear meniscus...
To investigate the lipid and DNA oxidative stress as well corneal retinal effects after ultraviolet B (UV-B) exposure in mice, with or without silicon hydrogel soft contact lenses (SCL).Twenty-eight C57BL6-strain male mice were divided into four groups: group I, control no SCL (SCL [-]) UV-B (UV-B [-]); II, senofilcon A (senofilcon [+]) [+]); III, lotrafilcon (lotrafilcon IV, [-]), but [+]). All except I received for 5 days a total dose of 2.73 J/cm(2). underwent tear hexanoyl-lysine (HEL)...
To evaluate the changes in functional visual acuity before and after neodymium:YAG (Nd:YAG) laser capsulotomy.Keio University Hospital, Tokyo, Japan.Case series.Eyes that had previous cataract surgery with a clinical diagnosis of central posterior capsule opacity requiring Nd:YAG capsulotomy were evaluated. All patients refractive error corrected distance (CDVA) measurements; slitlamp microscopy examinations, including opacification evaluation; high-contrast measured at 5 m using Landolt...