A5000405522- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Allergic Rhinitis and Sensitization
- Retinal Development and Disorders
- Salivary Gland Disorders and Functions
- Ocular Infections and Treatments
- Retinal Imaging and Analysis
- Olfactory and Sensory Function Studies
- Retinal and Optic Conditions
- Skin Protection and Aging
- Circadian rhythm and melatonin
- Connexins and lens biology
- Advanced Glycation End Products research
- Retinal and Macular Surgery
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Photoreceptor and optogenetics research
- Ocular Disorders and Treatments
- Nasolacrimal Duct Obstruction Treatments
- Ocular Oncology and Treatments
Keio University
2016-2025
Keio University Hospital
2015-2024
Santen (Japan)
2013-2024
Alcon (Japan)
2024
Rohto Pharmaceutical (United Kingdom)
2024
Tokyo Dental College Ichikawa General Hospital
2011-2023
Keio University Shonan Fujisawa
2011-2023
Ministry of Education, Culture, Sports, Science and Technology
2012-2023
Osaka Gas (Japan)
2023
Oduduwa University
2023
IgG4-related disease (IgG4RD) is a novel clinical entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration IgG4-positive plasma cells. IgG4RD may be present in certain proportion of patients with wide variety diseases, including Mikulicz's disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm, pseudotumor. Although...
<h3>Background:</h3> Mikulicz's disease (MD) has been considered as one manifestation of Sjögren's syndrome (SS). Recently, it also an IgG<sub>4</sub>-related disorder. <h3>Objective:</h3> To determine the differences between disorders including MD and SS. <h3>Methods:</h3> A study was undertaken to investigate patients with registered in Japan set up provisional criteria for new clinical entity IgG<sub>4</sub>-positive multiorgan lymphoproliferative (IgG<sub>4</sub>+MOLPS). The preliminary...
To evaluate the efficacy of autologous serum application for treatment dry eye in Sjögren's syndrome.The stability essential components (EGF, vitamin A, and TGF-beta) preserved were examined following preservation at 4 degrees C -20 C. In a primary clinical trial, 12 patients with syndrome treated (diluted to 20% sterile saline) weeks, vital staining ocular surface was compared before after treatment. The effects on mucin (MUC-1) expression observed cultured conjunctival epithelial cells...
Conditions that destroy the limbal area of peripheral cornea, such as Stevens–Johnson syndrome, ocular pemphigoid, and chemical thermal injuries, can deplete stem cells corneal epithelium. The result is scarring opacification normally clear cornea. Standard transplantation cannot treat this form functional blindness.
Oxidative stress has long been linked to the pathogenesis of neurodegenerative diseases; however, whether it is a cause or merely consequence degenerative process still unknown. We show that mice deficient in Cu, Zn-superoxide dismutase (SOD1) have features typical age-related macular degeneration humans. Investigations senescent Sod1(-/-) different ages showed older animals had drusen, thickened Bruch's membrane, and choroidal neovascularization. The number drusen increased with age,...
The demographic structure of a country changes dramatically with increasing trends toward general population aging and declining birth rates. In Japan, the percentage elderly (aged ≥65 years) reached 25% in 2013; it is expected to exceed 30% 2025 reach 39.9% 2060. national total has been decreasing steadily since its peak 2008, fall order 80 million Of population, those aged ≥75 years accounted for 12.3% as 2013, this 26.9% As changes, disease therefore medical care demand changes. To...
Diabetic retinopathy is a progressive neurodegenerative disease, but the underlying mechanism still obscure. Here, we focused on oxidative stress in retina, and analysed its influence retinal neurodegeneration, using an antioxidant, lutein.C57BL/6 mice with streptozotocin-induced diabetes were constantly fed either lutein-supplemented diet or control from onset of diabetes, their metabolic data recorded. In 1-month-diabetic mice, reactive oxygen species (ROS) retina measured dihydroethidium...
Salivary gland hypofunction, also known as xerostomia, occurs a result of radiation therapy for head cancer, Sjögren's syndrome or aging, and can cause variety critical oral health issues, including dental decay, bacterial infection, mastication dysfunction, swallowing dysfunction reduced quality life. Here we demonstrate the full functional regeneration salivary that reproduces morphogenesis induced by reciprocal epithelial mesenchymal interactions through orthotopic transplantation...