A5030876479- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Allergic Rhinitis and Sensitization
- Skin Protection and Aging
- Facial Rejuvenation and Surgery Techniques
- Ophthalmology and Eye Disorders
- Ocular Infections and Treatments
- Salivary Gland Disorders and Functions
- Intraocular Surgery and Lenses
- Nasolacrimal Duct Obstruction Treatments
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Dermatologic Treatments and Research
- Ergonomics and Musculoskeletal Disorders
- Olfactory and Sensory Function Studies
- Acne and Rosacea Treatments and Effects
- Botulinum Toxin and Related Neurological Disorders
- Ophthalmology and Visual Health Research
- Vestibular and auditory disorders
- Optimism, Hope, and Well-being
- Sympathectomy and Hyperhidrosis Treatments
- Intramuscular injections and effects
- Ocular Disorders and Treatments
Kyoto Prefectural University of Medicine
2013-2024
Ophthalmology Associates (United States)
2021
Kyoto College of Medical Science
2006
Senju Pharmaceutical (Japan)
2000
Gifu University
1996
There are limited reports on the relationship between mucin 5AC (MUC5AC) concentrations in tears, working hours, and frequency of ocular symptoms visual display terminal (VDT) users. This investigation evaluated these relationships among patients with dry eye disease (DED) individuals serving as controls.To determine MUC5AC concentration tears VDT users based diagnosis DED symptoms.An institutional, cross-sectional study was conducted. Participants included 96 young middle-aged Japanese...
Importance Dry eye disease has become an important health problem. A lack of concordance between self-reported symptoms and the outcome dry examinations raised questions about disease. Objective To explore association subjective happiness objective Design The study adopted a cross-sectional design. Setting All employees company in Osaka, Japan. Participants 672 Japanese office workers using Visual Display Terminals (age range: 26–64 years). Methods measurement tools included Schirmer test,...
Purpose: To investigate the association of dry eye disease with sleep quality. Methods: In 2011, a cross-sectional survey was conducted among all employees, mainly young and middle-aged Japanese office workers, who used visual display technology, at company in Osaka, Japan (N=672; age range =26–64 years). The participants were classified according to diagnosis criteria by examination results including Schirmer test, fluorescein lissamine green staining, tear film break-up time, symptom...
The corneal epithelium is essential for maintaining transparency, and efforts have been made to develop improved techniques epithelial transplantation in patients with total limbal failure. We evaluated the suitability of transplanted cultivated human conjunctival (HCjE) as a replacement rabbits deficiency.HCjE cells, on amniotic membrane (AM) confluence exposed an air-liquid interface (air-lifted), were onto denuded rabbit corneas monitored 2 weeks. HCjE sheet engrafted analyzed by...
To determine the feasibility of cultivated conjunctiva as a viable epithelial sheet for transplantation and corneal resurfacing in eyes with limbal stem cell deficiency (LSCD).Human (HCE) human conjunctival (HCjE) cells were on amniotic membrane (AM) to confluence then air lifted allow further stratification differentiation. Denuded AM HCE HCjE transplanted into 18 rabbits induced LSCD. The engrafted epithelia examined by transmission electron microscopy (TEM) immunohistochemistry. Two weeks...
Purpose . To assess the association of dry eye disease (DED) with physical activity and sedentary behavior. Methods The cross-sectional survey conducted included Japanese office workers who use visual display terminals (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">672</mml:mn></mml:math>). DED was assessed according to Dry Eye Diagnostic Criteria, participants were categorized into “definite DED,” “probable or...
Purpose: To report the clinical impact of conjunctivochalasis on ocular surface by evaluating effect a new concept operation resolution patients' symptoms and corneal epithelial damage. Also, association inflammation with is examined. Patients Methods: A total 168 eyes 131 patients (50 eyes) or without (118 dry eye who received newly designed were enrolled. All had prominent at lower tear meniscus their not sufficiently controlled usual eyedrop therapy. Subjective assessed before after...
The ocular surface is covered by two biologically distinct epithelia: corneal and conjunctival. expression of keratin12 (K12) currently considered a hallmark cornea-type differentiation. In the current study, biological features K12-positive cells in human bulbar conjunctival epithelium were examined.Human tissues subjected to investigate conjunctiva immunostaining, situ hybridization, Western blot analysis, reverse transcriptase-polymerase chain reaction (RT-PCR), fluorescence-activated...
Abstract The first aim of this study was to clarify whether cigarette smoking affects tear secretion, goblet cell density, and MUC5AC concentration. second purpose evaluate the correlations conjunctival density with concentration other ocular surface evaluation factors. This cross-sectional included 88 office workers. All subjects were required fill in dry eye questionnaires, addition evaluation. Tear wash fluid collected from inferior fornix, epithelium obtained by impression cytology....
<h3>AIMS/BACKGROUND</h3> The aim of this study was to assess quantitatively the effectiveness hyaluronan on corneal disruption in patients with dry eye. Corneal epithelial barrier function evaluated by measuring fluorescein permeability using a slit-lamp fluorophotometer. <h3>METHODS</h3> 11 eye were assigned study. Hyaluronan ophthalmic solution (0.1% hyaluronic acid) instilled five times day right eye, addition usual artificial tear solutions. left received only pretreatment day, and at 2...
To date, no studies have elucidated the composition of corneal filament in detail. In this study, an immunohistochemical technique was used to clarify exact filamentary keratitis. addition, mechanisms responsible for formation were identified.Filaments obtained from 13 patients with keratitis a background penetrating keratoplasty, aqueous tear deficiency, and severe ocular surface disorders, who receiving treatment at outpatient facility. From those tissues, transverse longitudinal frozen...
We determined whether functional visual acuity (VA) parameters and a dry eyes (DEs) symptoms questionnaire could predict DEs in population of terminal display (VDT) users.This prospective study included 491 VDT users from the Osaka Study. Subjects with definite DE, diagnosed presence DE symptoms, tear abnormality (Schirmer test ≤ 5 mm or breakup time [TBUT] seconds), conjunctivocorneal epithelial damage (total staining score ≥3 points), probable two them, were assigned to group, remainder...
To investigate the long-term effect of a topically applied β-blocker on human corneal epithelium, epithelial barrier function and superficial cell area epithelium were evaluated. Seventeen normal healthy volunteers (without medication), 7 cataract patients (treated with pyrenoxine eyedrops) glaucoma or ocular hypertension 0.5% timolol maleate) assigned to this study. The eyedrops had been used daily basis for at least 3 months. In evaluation function, fluorescein uptake was measured using...
Purpose: Considering that tears play the role of a lubricant, it is speculated in pathophysiology dry eye, increased friction during blinking results corneal and conjunctival damage, which may subsequently affect blink. The purpose this study was to investigate relationship between ocular surface epithelial tear abnormalities, blinks patients with eye. Methods: This involved 45 eyes female eye (mean age: 57.6 years). In all eyes, meniscus radius (mm), spread grade film lipid layer (SG: 1-5:...