A5083197095- Methane Hydrates and Related Phenomena
- Seismic Imaging and Inversion Techniques
- Cardiac Ischemia and Reperfusion
- Microbial Community Ecology and Physiology
- Hydrocarbon exploration and reservoir analysis
- Cardiac electrophysiology and arrhythmias
- Geology and Paleoclimatology Research
- Reservoir Engineering and Simulation Methods
- Geological and Geophysical Studies
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Head and Neck Cancer Studies
- Geophysics and Gravity Measurements
- Atmospheric and Environmental Gas Dynamics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Isotope Analysis in Ecology
- Advanced MRI Techniques and Applications
- Electron Spin Resonance Studies
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Adipose Tissue and Metabolism
- Salivary Gland Tumors Diagnosis and Treatment
- Diabetes and associated disorders
- Nitric Oxide and Endothelin Effects
Geological Survey of Japan
2021-2025
National Institute of Advanced Industrial Science and Technology
2016-2025
Kyoto University
2023
Yokohama City University
2023
Hot Springs Research Institute of Kanagawa Prefecture
2022
Niigata University
2011-2021
Japan Agency for Marine-Earth Science and Technology
2012-2021
Niigata Institute of Technology
2018-2020
JA Toride Medical Center
2020
Kitasato University
2019
<h3>Background:</h3> Mikulicz's disease (MD) has been considered as one manifestation of Sjögren's syndrome (SS). Recently, it also an IgG<sub>4</sub>-related disorder. <h3>Objective:</h3> To determine the differences between disorders including MD and SS. <h3>Methods:</h3> A study was undertaken to investigate patients with registered in Japan set up provisional criteria for new clinical entity IgG<sub>4</sub>-positive multiorgan lymphoproliferative (IgG<sub>4</sub>+MOLPS). The preliminary...
Microbial life inhabits deeply buried marine sediments, but the extent of this vast ecosystem remains poorly constrained. Here we provide evidence for existence microbial communities in ~40° to 60°C sediment associated with lignite coal beds at ~1.5 2.5 km below seafloor Pacific Ocean off Japan. methanogenesis was indicated by isotopic compositions methane and carbon dioxide, biomarkers, cultivation data, gas compositions. Concentrations indigenous cells 1.5 ranged from <10 ~10(4) cm(-3)....
To further characterize diurnal changes in the rhythm adrenal responsiveness to ACTH, we have measured ACTH distribution volume, MCR, and t½. These do not change between morning evening groups of untreated, dexamethasone-pretreated, or hypophysectomized female rats. nature dexamethasone-pretreated rats were infused for 2 h with a variety doses evening. The response an infusion rate that maximally stimulated adrenals (200 pg/100 g BW-min) was same evening, showing capacity does change....
Although oxygen free radicals have been implicated as mediators of cellular injury in myocardial ischemia-reperfusion, the exact nature defects produced by these is not clear. Because sarcolemmal Ca2+-pump involved efflux Ca2+ from cell, this study was undertaken to examine effects on ATP-dependent accumulation and Ca2+-stimulated Mg2+-dependent adenosinetriphosphatase (ATPase) activities well lipid peroxidation membrane phospholipids. Isolated rat heart membranes were incubated with...
Deep, hot, and more alive than we thought Marine sediments represent a massive microbial ecosystem, but still do not fully understand what factors shape limit life underneath the seafloor. Analyzing samples from subduction zone off coast of Japan, Heuer et al. found that life, in particular bacterial vegetative cells, decreases as depth temperature increases down to ∼600 meters below seafloor, corresponding temperatures ∼70°C. Below this limit, endospores are common—a remnant, potential...
Gas hydrates deposited in subseafloor sediments are considered to primarily consist of biogenic methane. However, little evidence for the occurrence living methanogens has been provided. This study investigated viable methanogen diversity, population, physiology and potential activity hydrate-bearing (1-307 m below seafloor) from eastern Nankai Trough. Radiotracer experiments, quantification coenzyme F430 molecular sequencing analysis indicated methanogenic predominance hydrogenotrophic...
Methanogenesis has been widely accepted as an ancient metabolism, but the precise evolutionary trajectory remains hotly debated. Disparate theories exist regarding its emergence time, ancestral form, and relationship with homologous metabolisms. Here, we report phylogenies of anabolism-involved proteins responsible for cofactor biosynthesis, providing new evidence antiquity methanogenesis. Revisiting key catabolism-involved further suggests that last Archaea common ancestor (LACA) was...
To understand the involvement of changes in sulfhydryl groups causing depression sarcolemmal Ca2+-pump activities, this study was undertaken to examine effects oxygen free radicals on rat heart groups, Ca2+-stimulated adenosinetriphosphatase (ATPase), and ATP-dependent Ca2+ accumulation. In addition, reagents such as dithiothreitol, cysteine, N-ethylmaleimide activities were investigated. The inhibition by O2-. (xanthine + xanthine oxidase) H2O2 decreased addition dithiothreitol or cysteine...
A co-culture of a novel thermoacidophilic, obligate symbiotic archaeon, designated as strain MJ1T, with its specific host archaeon Metallosphaera sedula MJ1HA was obtained from terrestrial hot spring in Japan. Strain MJ1T grew the under aerobic conditions. Coccoid cells were 200-500 nm diameter, and attached to co-culture. The ranges optima growth temperature pH 60-75 °C (optimum, 65-70 °C) 1.0-4.0 2.5), respectively. Core lipids dialkyl glycerol tetraethers (GDGT)-3 GDGT-4 highly abundant...
Although it has been suggested that humoral immunity plays a role in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage, there no quantitative assay for cellular immunity. We studied kinetics immune cells space hemorrhage rat. One hundred fourteen Sprague-Dawley rats were used this study. The animals divided into two groups and injected with either autologous blood (0.3 mL) or saline major cistern. They killed at specified time: 10 minutes 1, 2, 3, 5, 7 days hemorrhage. For...
Sex difference in the circadian periodicity of thehypothalamic content corticotropin-releasing factor (CRF) was examined rat. The CRF female hypothalamus higher morning than afternoon. In contrast, male rat under similar experimental conditions, afternoon morning. rat, a peak value found at 8 a.m. and precipitous fall ensued around noon, with concomitant sharp rise plasma cortico-sterone levels. Ovariectomy reduced levels without raising levels, occurring noon. Cervical ganglionectomy did...
Abstract Pirfenidone has been shown to modify some cytokine regulatory actions and inhibit fibroblast biochemical reactions resulting in inhibition of proliferation collagen matrix synthesis by fibroblast. We have investigated the effect pirfenidone on expression cell adhesion molecules. The synovial fibroblasts were treated with IL-1α presence or absence (range 0–1000 μm), assayed for molecules such as ICAM-1 endothelial-leucocyte molecule-1 (E-selectin) ELISA. significantly down-regulated...