A5078313362- Amyloidosis: Diagnosis, Treatment, Outcomes
- Dialysis and Renal Disease Management
- Erythropoietin and Anemia Treatment
- Hydrogen's biological and therapeutic effects
- Parathyroid Disorders and Treatments
- Iron Metabolism and Disorders
- Bone and Joint Diseases
- Bipolar Disorder and Treatment
- Aluminum toxicity and tolerance in plants and animals
- Electrochemical sensors and biosensors
- Muscle and Compartmental Disorders
- Dermatological and Skeletal Disorders
- Bone health and treatments
- Neurological and metabolic disorders
- Lymphatic Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Platelet Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Alzheimer's disease research and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Pharmacological Effects and Toxicity Studies
- Trace Elements in Health
Tokatsu Hospital
1996-2025
Mirai Hospital
2017-2023
National Hospital Organization Mito Medical Center
2013-2015
Tokyo Women's Medical University Adachi Medical Center
2012
Nikko Memorial Hospital
2010
Shibaura Institute of Technology
1997
Tokyo National Hospital
1992-1995
Hokko Chemical Industry (Japan)
1988
Background. Chronic inflammation in haemodialysis (HD) patients indicates a poor prognosis. However, therapeutic approaches are limited. Hydrogen gas (H2) ameliorates oxidative and inflammatory injuries to organs animal models. We developed an HD system using dialysis solution with high levels of dissolved H2 examined the clinical effects.
Chronic kidney disease remains a significant global health challenge, with substantial proportion of patients progressing to end-stage renal disease, necessitating replacement therapies (RRT) such as hemodialysis (HD).[1] Despite advancements in dialysis techniques, on long-term HD experience heightened oxidative stress and systemic inflammation, contributing an elevated risk cardiovascular mortality. Malnutrition-inflammation-atherosclerosis syndrome, first described 2000, is pivotal...
Object: To study the effects of intravenous administration methylcobalamin, an analogue vitamin B12, for uremic or uremic-diabetic polyneuropathy in patients who are receiving maintenance hemodiaiysis. An ultra-high dose B12 has been reported to promote peripheral nerve regeneration experimental neuropathy. Methods: Nine received a 500μg methylcobalamin injection 3 times week 6 months. The were evaluated using neuropathic pain grading and conduction study. Results: Serum concentrations...
Abstract Recent studies have revealed unique biological characteristics of molecular hydrogen (H 2 ) as an anti-inflammatory agent. We developed a novel haemodialysis (E-HD) system delivering H (30–80 ppb)-enriched dialysis solution by water electrolysis, and conducted non-randomized, non-blinded, prospective observational study exploring its clinical impact. Prevalent chronic HD patients were allocated to either the E-HD (n = 161) group or conventional (C-HD: n 148) group, received...
Abstract Pirfenidone has been shown to modify some cytokine regulatory actions and inhibit fibroblast biochemical reactions resulting in inhibition of proliferation collagen matrix synthesis by fibroblast. We have investigated the effect pirfenidone on expression cell adhesion molecules. The synovial fibroblasts were treated with IL-1α presence or absence (range 0–1000 μm), assayed for molecules such as ICAM-1 endothelial-leucocyte molecule-1 (E-selectin) ELISA. significantly down-regulated...
Abstract Elevated oxidative stress ( OS ) is associated with severe cardiovascular disease and premature death among patients treated hemodialysis HD ). Oxidative enhanced by contact between blood dialysis membranes during sessions. This study aimed to clarify whether hydrogen H 2 ), which a known antioxidant, capable of suppressing increased induced Eight on regular treatment were studied. Two sessions performed in cross‐over design trial using standard hydrogen‐enriched solutions (mean 50...
Dialysis-related amyloidosis (DRA) is characterized by the presence of beta 2-microglobulin (beta 2-m) in plasma. In order to eliminate 2-m from circulating blood, selective adsorbent for direct hemoperfusion (DHP) was developed. A DHP column (BM-01), containing 350 ml adsorbent, subjected clinical trials. The connected with a PAN (AN69) membrane dialyzer series and used 3 times week 1 (11 patients), 4 weeks (5 6 months (1 patient) 12 (2 patients). percent reduction (%) 16 patients (for or...
Abstract: We investigated the clinical efficacy of direct hemoperfusion with a β 2 ‐microglobulin (β ‐m) adsorption column for treatment patients dialysis‐related amyloidosis. A 2‐year prospective controlled study was performed to compare effects passaging blood through (Lixelle) before it is passaged dialysis polysulfone membrane on severity amyloidosis in these individuals. Patients ( n = 22) whose went Lixelle prior had higher ‐m removal rate compared an equal number controls, and they...
Abstract Dialysis‐related amyloidosis is a serious complication of long‐term hemodialysis. Its pathogenic mechanism involves accumulation β2‐microglobulin in the blood, which then forms amyloid fibrils and deposited tissues, leading to inflammation activation osteoclasts. Lixelle, direct hemoperfusion column for adsorption β2‐microglobulin, has been available since 1996 treat dialysis‐related Japan. However, previous studies showing therapeutic efficacy Lixelle were conducted small numbers...
The occurrence of various arthropathies including carpal-tunnel syndrome (CTS) in dialysis-associated amyloidosis, a condition caused by the deposition β2 microglobulin (β2MG), has been emphasized for several years. We attempted to analyse pathogenesis CTS haemodialysis-associated amyloidosis (HA). expression cell adhesion molecules and inflammatory cytokines tenosynovial tissues was determined using both reverse-transcriptase polymerase chain reaction (RT-PCR) immunostaining. There marked...
Abstract: The clinical efficacy and safety of a β 2 –microglobulin (β M) adsorbent column, BM–01, on the treatment dialysis‐related amyloidosis were investigated in 7 hemodialysis patients for more than 6 months. percent reduction serum M was 60–70%, level at end each session less 10 mg/L almost all patients. amount removed calculated as 200–300 mg/session. results demonstrated that BM–01 performed very well removing M, capable maintaining 25 time average concentration (TAC) improved...
Summary Background and objectives A 1-year multicenter prospective randomized controlled study was conducted on the effects of vitamin E-bonded polysulfone dialyzers erythropoiesis-stimulating agent response in hemodialysis patients. Design, setting, participants, & measurements Major inclusion criteria were use high-flux with 50–70 ml/min β 2 -microglobulin clearance over 3 months, transferrin saturation 20%, same for hemoglobin at 10–12 g/dl. Hemodialysis patients placed four...
Abstract: Low‐density lipoprotein (LDL) apheresis has been applied to patients with familial hypercholesterolemia (FH) coronary artery disease (CAD). To examine the efficacy and safety of a new type LDL adsorption column (KLD01, Kaneka, Osaka, Japan), which deals whole blood without separating plasma, system was evaluated in multicenter trial. The present study included 33 FH CAD (24 males, 9 females, 57 ± 13 years) who were treated five times mean interval 2.12 0.60 weeks between...
Background and aim It is supposed that enhanced oxidative stress inflammation are involved with the poor clinical outcomes in patients on chronic dialysis treatment. Recent studies have shown molecular hydrogen (H2) biologically active as an anti-inflammatory agent. Thus, we developed a novel hemodialysis (E-HD) system which delivers H2 (30 to 80 ppb)-enriched solution, conduct prospective observational study (UMIN000004857) order compare long-term between E-HD conventional-HD (C-HD) Japan....
The effect of the prostaglandin I2 analog, beraprost sodium (BPS), on hemodialysis (HD) patients with peripheral arterial disease (PAD) has not been fully elucidated. BPS was compared to that PAD drugs in HD a multicenter randomized prospective interventional pilot study (J-PADD). Seventy-two were entered and randomly divided into two groups; is, group (Group A: n = 35) drug (cilostazol or sarpogrelate) B: 37). Primary endpoint changes skin perfusion pressure (SPP). Kidney Disease Quality...
Dialysis membranes are generally considered to be impermeable for bacterial endotoxin (lipopolysaccharide, LPS) contaminated in dialysates used hemodialysis therapy, since LPS molecular size aqueous media has been reported more than 10(6). However, there few reports concerning its dialysates. We have already presented a newly developed polyacrylamide gel electrophoresis with sodium deoxycholate (DOC-PAGE) which proves the size. Using this method, therefore, we attempted clarify of...
Oral ferric citrate hydrate (FCH) is effective for iron deficiency in hemodialysis patients.; however, it remains unclear how balance the body affects absorption from intestinal tract. This prospective, observational study (Riona-Oral Iron Absorption Trial, R-OIAT, UMIN 000031406), conducted at 42 centers Japan, wherein 268 patients without inflammation were enrolled and treated with a fixed amount of FCH 6 months. We assessed predictive value hepcidin-25 shift between ferritin (FTN) red...
Oral ferric citrate hydrate (FCH) is effective for iron deficiencies in hemodialysis patients; however, how balance the body affects absorption intestinal tract remains unclear. This prospective observational study (Riona-Oral Iron Absorption Trial, R-OIAT, UMIN 000031406) was conducted at 42 centers Japan, wherein 268 patients without inflammation were enrolled and treated with a fixed amount of FCH 6 months. We assessed predictive value hepcidin-25 shift between ferritin (FTN) red blood...