A5079821787- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Blood Pressure and Hypertension Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Liver Disease Diagnosis and Treatment
- Health Promotion and Cardiovascular Prevention
- Chronic Disease Management Strategies
- Renal Transplantation Outcomes and Treatments
- Parathyroid Disorders and Treatments
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Renal and Vascular Pathologies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Erythropoietin and Anemia Treatment
- Potassium and Related Disorders
- Alcohol Consumption and Health Effects
- Pharmacological Effects and Toxicity Studies
- Autoimmune Bullous Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Nutritional Studies and Diet
- Sarcoidosis and Beryllium Toxicity Research
- Monoclonal and Polyclonal Antibodies Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University of Tsukuba
2016-2025
Hitachi General Hospital
1994-2025
ChemoCentryx (United States)
2023
University of Oxford
2023
University of Tsukuba Hospital
2022
Ministry of Health Labour and Welfare
2014-2021
Fukushima Medical University
2016-2021
Chiba Prefectural University of Health Sciences
2019
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2018
Montavid Thermodynamic Research Group
2018
Abstract Comparative analysis of cytoplasmic organelles in a variety tumors relative to normal tissues generally reveals strong diminution mitochondrial content and oxidative phosphorylation capacity. However, little is known about what triggers these modifications whether or not they are physiologically reversible. We hypothesized that energy substrate availability could play an important role this phenomenon. The physiological effects change were examined on human cancer cell line (HeLa),...
Rationale & ObjectiveEpidemiologic and clinical studies have suggested that urate-lowering therapy may slow the progression of chronic kidney disease (CKD). However, definitive evidence is lacking.Study DesignRandomized, double-blind, placebo-controlled trial.Setting Participants467 patients with stage 3 CKD asymptomatic hyperuricemia at 55 medical institutions in Japan.InterventionParticipants were randomly assigned a 1:1 ratio to receive febuxostat or placebo for 108 weeks.OutcomesThe...
A nationwide statistical survey of 4255 dialysis facilities was conducted at the end 2011. Responses were submitted by 4213 (99.0%). The number new patients started on 38,613 in Although decreased 2009 and 2010, it increased who died each year has been increasing; 30,743 2011, which exceeded 30,000 for first time. undergoing also increasing every year; 304,856 300,000 per million 2011 2385.4. crude death rate 10.2%, 10% time last 20 years. mean age 67.84 years entire patient population 66.55...
A nationwide statistical survey of 4124 dialysis facilities was conducted at the end 2008 and 4081 (99.0%) responded. The number patients undergoing determined to be 283,421, an increase 8179 (3.0%) compared with that 2007. per million 2220. crude death rate from 2007 9.8%. mean age new begun on 67.2 years entire patient population 65.3 years. For primary diseases dialysis, percentages diabetic nephropathy chronic glomerulonephritis were 43.3% 22.8%, respectively. Among measured bacterial...
Abstract A nationwide statistical survey of 4226 dialysis facilities was conducted at the end 2010, and 4166 (98.6%) responded. The number new patients introduced into 37 512 in 2010. This has decreased for two consecutive years since it peaked 2008. who died 2010 28 882, which been increasing every year. undergoing 298 252, is an increase 7591 (2.6%) compared with that 2009. per million 2329.1. crude death rate 9.8%, gradually increasing. mean age 67.8 entire patient population 66.2 years....
In recent years, a concept of renal rehabilitation has become widely known among nephrology specialists, dialysis kidney transplantation nutrition guideline nurses, physiotherapists, and representatives patients. Therefore, in order to make it clear the definition, methods, effectiveness Japan, we launched Renal Rehabilitation Guideline Preparation Committee 2016 as part works Japanese Society Rehabilitation, created accordance "Minds Handbook for Clinical Practice Development 2014". Here,...
Constipation is one of the most prevalent conditions in primary care settings and increases risk cardiovascular disease, potentially through processes mediated by altered gut microbiota. However, little known about association constipation with CKD. In a nationwide cohort 3,504,732 United States veterans an eGFR ≥60 ml/min per 1.73 m 2 , we examined status severity (absent, mild, or moderate/severe), defined using diagnostic codes laxative use, incident CKD, ESRD, change Cox models (for...
The Japan Chronic Kidney Disease Database (J-CKD-DB) is a nationwide clinical database of patients with chronic kidney disease (CKD) based on electronic health records. objective this study was to assess the prevalence anemia and utilization rate erythropoiesis-stimulating agents (ESAs) in Japanese CKD.In total, 31,082 adult outpatients estimated glomerular filtration rates 5-60 ml/min/1.73 m2 seven university hospitals were included analysis. proportions CKD stages G3b, G4, G5 23.5%, 7.6%,...
Randomized controlled trials have shown kidney-protective effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors, and clinical practice databases suggested that these translate to practice. However, long-term efficacy, as well whether the presence or absence proteinuria rate estimated glomerular filtration rates (eGFR) decline prior SGLT2 inhibitor initiation modify treatment efficacy among type diabetes mellitus (T2DM) chronic kidney disease (CKD) patients, is unknown.Using Japan...
Summary To determine the cytokine balance in patients with lupus nephritis (LN), we analysed kidney-infiltrating T cells. Renal biopsy samples from 15 systemic erythematosus (SLE) were used. In accordance classification of International Society Nephrology/Renal Pathology Society, they categorized into Class III, III+V (Class III-predominant group, n = 4), IV, IV+V IV-predominant 7) and V (n 4) groups. The single-cell both glomelular interstitial infiltrating cells captured by...