A5105927384- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
- Vitamin D Research Studies
- Lysosomal Storage Disorders Research
- Cardiovascular Function and Risk Factors
- Magnesium in Health and Disease
- Fibroblast Growth Factor Research
- Potassium and Related Disorders
- Trypanosoma species research and implications
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Aortic aneurysm repair treatments
- Advanced Glycation End Products research
- Bone health and osteoporosis research
- Biomedical Research and Pathophysiology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal cell carcinoma treatment
- Renal Diseases and Glomerulopathies
- Diabetes Treatment and Management
- Renal and Vascular Pathologies
- Thyroid and Parathyroid Surgery
- Heart Failure Treatment and Management
- Renal Transplantation Outcomes and Treatments
Kobe University
2015-2024
University of Oxford
2023
Tohoku University
2019
Bridge University
2017
KU Leuven
2017
Medical University of Silesia
2012
In recent years, a concept of renal rehabilitation has become widely known among nephrology specialists, dialysis kidney transplantation nutrition guideline nurses, physiotherapists, and representatives patients. Therefore, in order to make it clear the definition, methods, effectiveness Japan, we launched Renal Rehabilitation Guideline Preparation Committee 2016 as part works Japanese Society Rehabilitation, created accordance "Minds Handbook for Clinical Practice Development 2014". Here,...
<i>Background:</i> The role of nitric oxide (NO) is controversial in diabetes nephropathy progression and the mechanisms remain unknown, especially non-obese type 2 diabetes. To examine diabetes, we used spontaneously diabetic Torii (SDT) rats, a newly established model <i>Methods:</i> Fourteen male Sprague-Dawley rats were as control (20 weeks, n = 6; 30 8), 20-week-old SDT divided into groups: (DM, 8) DM + insulin (n groups. Twenty- 36-week-old sacrificed, blood,...
<b><i>Background/Aims:</i></b> Vascular disease is one of the critical complications diabetes. A growing body evidence suggests that oxidative stress plays a key role for vascular progression. Recent studies have demonstrated strong link between vitamin D and cardiovascular disease. <b><i>Methods:</i></b> We investigated anti-oxidative effects analog, 22-oxacalcitriol (maxacalcitol), on lesions in type 2 diabetic rats. used Spontaneously...
Serum phosphate control is crucial for the progression of vascular and valvular calcifications. Strict recently suggested; however, there a lack convincing evidence. Therefore, we explored effects strict on calcifications in incident patients undergoing hemodialysis.A total 64 hemodialysis from our previous randomized controlled trial were included this study. Coronary artery calcification score (CACS) cardiac (CVCS) evaluated using computed tomography ultrasound cardiography at baseline 18...
Cardiovascular disease (CVD) is a leading cause of death in chronic kidney (CKD) patients. One the proposed mechanisms assumes that accumulated uremic toxins play an important role progression CVD CKD. Recently, it has been reported AST-120 may attenuate through absorption toxins. In this study, we examined association between use and cardiac abnormalities CKD patients.This was cross-sectional study predialysis patients hospitalized our institution April 2008 October 2009. We divided 107...
Background and Purpose Chronic kidney disease (CKD) is a crucial risk factor for cardiovascular (CVD), combined CKD CVD further increases morbidity mortality. Here, we investigated effects of AST‐120 on oxidative stress injury using model myocardial infarction (MI) in rats. Experimental Approach At 10 weeks, male spontaneously hypertensive rats (SHR) were divided into three groups: SHR ( n = 6), MI 8) + 8). administration was started at 11 weeks after MI. 18 the killed, blood urine, mRNA...
<i>Background:</i> Fabry disease (FD) is a rare and one of the causes progressive renal dysfunction. It results from an X-linked deficiency α-galactosidase A activity. has been reported that its prevalence much higher in hemodialysis patients than general population. However, Japanese cardiovascular manifestations remain unclear. <i>Methods:</i> We screened activity 1,024 using dried blood spot test. Patients with low were assessed clinically, genetic study gene was...
We investigated whether certainty and uncertainty of impending aversive visceral sensation differently modulate regional brain activity, both during anticipation in irritable bowel syndrome (IBS) patients compared with healthy controls.Twenty-six IBS (14 women) 29 controls (15 were enrolled a functional magnetic resonance imaging study. Participants received rectal distention at an individually titrated severe discomfort level that was preceded by visual cues to induce certain (100% chance...
Abstract Vascular calcification (VC) is a common complication in patients with chronic kidney disease (CKD). Particularly, CKD diabetes mellitus (DM) develop severe VC. Specific mechanisms of VC remain unclear; this study aimed to investigate them the context coexisting and DM, mainly regarding oxidative stress. Sprague Dawley rats were randomly divided into six groups as follows: control (Control), 5/6 nephrectomized (CKD), streptozotocin-injected (DM), (CKD + DM), DM treated insulin INS),...
Astragalus root is a commonly used herb in traditional Chinese medicine. Although renoprotective effects have been reported some clinical and experimental studies, the details remain unknown.We 5/6 nephrectomized rats as chronic kidney disease (CKD) models. At 10 weeks, they were divided into four groups, namely, CKD, low-dose astragalus (AR400), high-dose (AR800), sham groups. 14 sacrificed for evaluation of blood, urine, mRNA expression kidney, renal histopathology.Kidney dysfunction was...
Most dialysis patients have coronary artery disease at the initiation of therapy and these also marked vascular calcification. Virtual histology-intravascular ultrasound (VH-IVUS) provides tissue maps that are color coded by four major plaque components facilitate characterization composition in vivo. The aim this study was to identify characteristics using VH-IVUS. Twenty-three with were included study. Of these, 12 had normal renal function or mild insufficiency (control group) 11...
<b><i>Background/Aims:</i></b> The purpose of our study was to elucidate the relationship between asymmetric dimethylarginine (ADMA) and intrarenal lesions determine effect renin-angiotensin system inhibitors (RAS-Is) on serum ADMA levels, nitric oxide (NO) synthesis oxidative stress in normotensive patients with chronic kidney disease (CKD). <b><i>Methods:</i></b> This included 23 glomerulonephritis normal or mildly impaired renal function who...
Hypertension (HT) is a common complication in patients with chronic kidney disease (CKD). However, the relationship between circadian rhythm disorder of blood pressure (BP) and intra-renal damage remains unclear.Ninety glomerular (CGD) were included present study. On basis clinic BP (CBP) 24 h-ambulatory (ABP) measurements, divided into following groups; normotension (NT), white coat HT (WHT), masked (MHT), sustained (SHT). For renal histopathological assessment, we evaluated each biopsy...
Abstract The nociceptive and autonomic nervous systems (ANS) are significantly intertwined. Decoupling of these may occur in pathological pain conditions, including irritable bowel syndrome (IBS). We investigated ANS activity its association with visceral perception brain during rectal distention 27 patients non-constipated IBS 33 controls by assessing heart rate variability (HRV) using electrocardiography at rest, before, colorectal distention. Brain responses to were measured functional...