A5054646745- Renal Diseases and Glomerulopathies
- Genetic and Kidney Cyst Diseases
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Parathyroid Disorders and Treatments
- Renal and related cancers
- Pediatric Urology and Nephrology Studies
- IgG4-Related and Inflammatory Diseases
- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- Diabetes Treatment and Management
- Genetic Syndromes and Imprinting
- Renal cell carcinoma treatment
- Complement system in diseases
- Bone health and treatments
- Sarcoidosis and Beryllium Toxicity Research
- Biomedical Research and Pathophysiology
- Systemic Sclerosis and Related Diseases
- Viral-associated cancers and disorders
- Rheumatoid Arthritis Research and Therapies
- Liver Disease Diagnosis and Treatment
- Cystic Fibrosis Research Advances
Toranomon Hospital
2016-2025
Kanazawa University
2018-2023
Kanazawa Medical University
2023
Joslin Diabetes Center
2015-2018
Harvard University
2015-2018
Hospital Clínic de Barcelona
2017
Ospedale Annunziata di Cosenza
2017
Kyorin University
2014
Okinaka Memorial Institute for Medical Research
2013
In recent years, a concept of renal rehabilitation has become widely known among nephrology specialists, dialysis kidney transplantation nutrition guideline nurses, physiotherapists, and representatives patients. Therefore, in order to make it clear the definition, methods, effectiveness Japan, we launched Renal Rehabilitation Guideline Preparation Committee 2016 as part works Japanese Society Rehabilitation, created accordance "Minds Handbook for Clinical Practice Development 2014". Here,...
Some biomarkers of renal tubular injury are reported to be useful for predicting prognosis in the early stage diabetic nephropathy (DN). Our study compared predictions by such and histologic tubulointerstitial damage.Among 210 patients with type 2 diabetes biopsy-proven DN managed from 1985 2011, 149 urinary N-acetyl-β-d-glucosaminidase (NAG) β2-microglobulin (β2-MG) data at time biopsy were enrolled. The primary outcome was a decline eGFR ≥50% baseline or commencement dialysis ESRD.The...
OBJECTIVE Clinicopathological characteristics, renal prognosis, and mortality in patients with type 2 diabetes reduced function without overt proteinuria are scarce. RESEARCH DESIGN AND METHODS We retrospectively assessed 526 (estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m2), who underwent clinical biopsy had follow-up data, from Japan’s nationwide multicenter registry. For comparative analyses, we derived one-to-two cohorts of those versus using propensity...
BackgroundA new classification of diabetic nephropathy was reported by Tervaert et al., but the association between pathological findings and clinical outcomes remains unclear.
The effect of clinical and pathological parameters on the estimated glomerular filtration rate (eGFR) decline has not been investigated in patients with type 2 diabetes overt proteinuric biopsy-proven diabetic nephropathy.Among 198 who underwent renal biopsy were confirmed to have pure nephropathy according recent classification, 128 proteinuria enrolled. Receiver operating characteristic, net reclassification improvement (NRI) integrated discrimination (IDI) analyses performed using models...
Abstract Evidence for the efficacy of denosumab in HD patients is limited. Accordingly, here we report a study on safety and these patients. We prospectively followed 324 (121 203 non-HD patients) receiving between June 2013 May 2018, assessing changes bone mineral density (BMD) metabolic markers, noting side-effects. Annual BMD at lumbar spine from baseline were, respectively, 6.7 ± 11.1% 7.5 10.2% ( p = 0.60), those femoral neck were 4.3 7.9% 3.1 9.5% 0.32), distal radius −0.5 6.4% 0.2...
Abstract Objectives To evaluate the efficacy and safety of first-line targeted synthetic disease-modifying anti-rheumatic drugs (tsDMARDs) in patients with rheumatoid arthritis (RA) chronic kidney disease (CKD). Methods This retrospective cohort study included 216 RA prescribed their first tsDMARDs at two hospitals between 2013 2022. Dose reduction contraindication guidelines for according to function were followed. The categorised by tsDMARD modality. primary outcome was 24-month drug...
A 75-year-old man with a fever, shoulder pain, and lower leg edema was diagnosed polymyalgia rheumatica started on glucocorticoid therapy. Eighteen months later, he admitted rapidly progressive renal failure. Glucocorticoid therapy had been discontinued one month prior to admission. Serum anti-glomerular basement membrane antibodies were elevated, kidney biopsy revealed fibrinoid necrosis of the medium-sized arteries, tubulointerstitial nephritis, collapsed glomeruli. An immunofluorescence...
We describe the case of a 25-year-old male with Duchenne muscular dystrophy and acute kidney injury who was receiving mechanical ventilation. The patient's estimated glomerular filtration rate (eGFR) assessed using formulas based on creatinine, cystatin C, inulin levels over time during recovery his renal function. creatinine-based eGFR extremely high throughout study period. Cystatin C-based also higher than clearance. These findings suggest that may exceed clearance in patients an reduced...
To evaluate the pathological and clinical course differences between bucillamine‑induced membranous nephropathy (BCL-MN) primary (p-MN). This retrospective cohort study included 29 BCL-MN patients 98 p-MN at two hospitals from 2000 to 2019. We compared kidney biopsy findings groups, focusing on differences, proteinuria relapse rates, 30% or greater decrease in eGFR. While function levels were similar, histopathological observed. group showed less spike formation LM more stage I cases. IgG1...
The quality of life (QOL) patients with autosomal dominant polycystic kidney disease (ADPKD) has not been investigated well. This study was performed to clarify the QOL ADPKD and identify factors that affected their QOL. present cross-sectional is part a prospective observational on patients. Patients who were referred Toranomon Hospital between March 2010 November 2012 enrolled. short form-36 (SF-36) questionnaire our original 12-item used evaluate We analyzed results survey then...
<b><i>Background:</i></b> With the association between diabetic nephropathy (DN) and renal outcome being increasingly clear, we aimed at creating a new DN pathological scoring system that could predict outcome. <b><i>Methods:</i></b> We studied 205 patients with confirmed by biopsy, sometime March 1985 January 2010, who met inclusion criteria. Renal biopsy included clinical parameters Tervaert classifications. Hazard ratios (HRs) for...