A5079486783- Cancer Genomics and Diagnostics
- Shoulder Injury and Treatment
- Coronary Interventions and Diagnostics
- Shoulder and Clavicle Injuries
- Epigenetics and DNA Methylation
- Nerve Injury and Rehabilitation
- Genetic Syndromes and Imprinting
- Cerebrovascular and Carotid Artery Diseases
- Prenatal Screening and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Orthopedic Surgery and Rehabilitation
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Bioinformatics and Genomic Networks
- Genomics and Chromatin Dynamics
- Evolution and Genetic Dynamics
- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- RNA modifications and cancer
- Optical Coherence Tomography Applications
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
Asahikawa Medical University
2013-2024
Daiichi-Sankyo (Japan)
2017-2023
Tokushima University
2022
Tokyo University of Science
1991-2020
Asahikawa Medical College Hospital
2011-2014
Kobe University
2008-2012
Hyogo Brain and Heart Center
2011
The University of Tokyo
1982-2010
Miyoshi Kasei (Japan)
2009
Wellcome/Cancer Research UK Gurdon Institute
2005-2006
The paternal duplication of mouse distal chromosome 12 leads to late embryonal/neonatal lethality and growth promotion, whereas maternal embryonal retardation. Human or uniparental disomies 14q that are syntenic have also been reported show some imprinting effects on growth, mental activity musculoskeletal morphology. For the isolation imprinted genes in this region, a systematic screen maternally expressed (Megs) was carried out by our subtraction-hybridization method using androgenetic...
To evaluate the feasibility of combined use virtual histology (VH)-intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for detecting in vivo thin-cap fibroatheroma (TCFA). In 56 patients with angina, 126 plaques identified by IVUS findings were analysed using both VH-IVUS OCT. IVUS-derived TCFA was defined as an abundant necrotic core (>10% cross-sectional area) contact lumen (NCCL) %plaque-volume >40%. OCT-derived a fibrous cap thickness <65 µm overlying low-intensity...
The mouse Peg1/Mest gene is an imprinted that expressed particularly in mesodermal tissues early embryonic stages. It was the most abundant among eight paternally genes (Peg 1–8) isolated by a subtraction-hybridization method from embryonal cDNA library. has been mapped to proximal chromosome 6, maternal duplication of which causes lethality. human chromosomal region shares syntenic homology with this 7q21-qter, and uniparental disomy 7 (UPD 7) apparent growth deficiency slight morphological...
In a systematic screen for maternally expressed imprinted genes using subtraction hybridization with androgenetic and normal fertilized mouse embryos, seven candidate ( Megs ) have been isolated, including the H19 p57 Kip2 that are known to be expressed. Herein, we demonstrate an gene, Meg1 , is apparently identical Grb10 (growth factor receptor-bound protein 10), which located on proximal chromosome 11. was reported bind insulin receptor and/or insulin-like growth (IGF) I via its src...
Peg3 encodes a C2H2 type zinc finger protein that is implicated in novel physiological pathway regulating core body temperature, feeding behavior, and obesity mice. Peg3+/- mutant mice develop an excess of abdominal, subcutaneous, intra-scapular fat, despite lifetime lower food intake than wild-type animals. However, they start life with reduced fat reserves are slower to enter puberty. These maintain fail respond cold challenge, have metabolic activity as measured by oxygen consumption....
In cardiac myocytes, regulation of mitochondrial Ca2+ is important for cellular signaling and contraction. entry into the mitochondria mediated by a highly selective channel called calcium uniporter, which consists pore-forming subunit MCU regulatory subunits such as MICU1. Although pharmacological influx promising approach to controlling functions, cell-permeable specific inhibitor uniporter has not yet been developed. Here, we identify novel high-throughput screening 120 000 small-molecule...
Genomic imprinting significantly influences development, growth and behaviour in mammals. Systematic screening of imprinted genes has been extensively carried out to identify the responsible for phenotypes elucidate biological significance this phenomenon. In study, we applied DNA chip technology isolating paternally expressed ( Pegs ). We compared resulting expression profiles parthenogenetic fertilized control embryos novel genes. A mouse gene, Peg9/Dlk1 , was identified. Consistent with...
Background: Sirolimus-eluting stents (SES) have incomplete neointimal coverage at 6-month follow up as determined with optical coherence tomography (OCT). The long-term detailed changes of neointima in SES remains to be clarified. Methods and Results: Serial from 6 months 12 using OCT were examined. Of 21 13 patients, was used visualize 2,321 stent struts 2,285 months. frequency without decreased (from 10.4 5.7%). malapposed 1.7 0.2%). average thickness the increased 112 ±123 120 ±130 μm)....
<h3>Objective</h3> The aim of this study was to evaluate detailed vessel response after everolimus-eluting stents (EES) implantation in human de novo coronary lesions by optical coherence tomography (OCT). <h3>Design, setting and patients</h3> Between November 2008 October 2009, 25 patients (14 men, 65.5±8.6 years) with native artery were implanted 30 EES, OCT performed at 8 months post-implantation. <h3>Main outcome measures</h3> Neointimal thickness (NIT) on each strut, strut apposition...
Background: Differences between paclitaxel-eluting stents (PES) and sirolimus-eluting stent (SES) in neointimal proliferation under strictly matched conditions remain to be clarified by optical coherence tomography (OCT). Methods Results: Between May December 2007, 27 patients were implanted with a PES SES, randomized either the proximal or distal site single coronary artery, underwent follow-up angiography OCT examination at 6 months. The frequency of vessel wall apposition neointima was...
Factors influencing measurements and accurate evaluation of stent apposition by optical coherence tomography (OCT) are not established.Phantom models known luminal sizes lengths were evaluated OCT under various conditions compared with actual values. Stents implanted into phantom examined to validate the measurement point on strut surface for apposition. Strut thickness was measured at 3 points (midpoint, inner outer surfaces shadow). The precision lumen diameter area satisfactory when image...
Background Pioglitazone has a preventive effect on cardiovascular disease, but its ability to stabilize coronary plaque is unknown. Methods and Results A prospective, randomized trial was conducted in 54 patients with type 2 diabetes stable angina pectoris, randomly assigned either pioglitazone group or control group. Non-culprit, angiographically mild-to-moderate obstructive lesions were examined virtual histology intravascular ultrasound (VH-IVUS) at intervention 6 months later. In total,...
We hypothesized that the tissue components of in-stent restenosis (ISR) might differ between drug-eluting stents (DES) and bare-metal (BMS) these differences could be distinguished by qualitative quantitative optical coherence tomography (OCT) analyses.One-hundred twenty-two initial ISR lesions (sirolimus-eluting stents: n=28; paclitaxel-eluting n=51; BMS: n=43) were evaluated with OCT. Based on their OCT appearance, classified as homogeneous, layered or heterogeneous. The properties...
Abstract The International Cancer Genome Consortium (ICGC)’s Pan-Cancer Analysis of Whole Genomes (PCAWG) project aimed to categorize somatic and germline variations in both coding non-coding regions over 2,800 cancer patients. To provide this dataset the research working groups for downstream analysis, PCAWG Technical Working Group marshalled ~800TB sequencing data from distributed geographical locations; developed portable software uniform alignment, variant calling, artifact filtering...
Humeral stem loosening has gained attention as it been identified a cause of revision surgery in reverse shoulder arthroplasty (RSA). In RSA, humeral is very difficult if there bone loss because stress shielding. Some studies resorption after anatomic have published, but are few detailed reports RSA. This study aimed to investigate the prevalence RSA procedures and evaluate risk factors for resorption.This included 48 shoulders that underwent with an uncemented from July 2014 May 2017 were...