A5004220189- Coronary Interventions and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiomyopathy and Myosin Studies
- Lipoproteins and Cardiovascular Health
- Ovarian function and disorders
- Body Contouring and Surgery
- Congenital Heart Disease Studies
- Peroxisome Proliferator-Activated Receptors
- Biosimilars and Bioanalytical Methods
- Oral and gingival health research
- Cardiovascular and Diving-Related Complications
- Advanced Glycation End Products research
- Bone health and treatments
- Cerebrovascular and Carotid Artery Diseases
- Lipid metabolism and disorders
- Cellular transport and secretion
- Mitochondrial Function and Pathology
- Hepatitis B Virus Studies
- Nitric Oxide and Endothelin Effects
Kobe University
1990-2024
Murata (Japan)
2024
We performed this study to clarify natural consequences of abnormal structures (stent malapposition, thrombus, tissue prolapse, and stent edge dissection) after percutaneous coronary intervention (PCI). Thirty-five patients treated with 40 drug-eluting stents underwent serial optical coherence tomography (OCT) imaging immediately PCI at the 8-month follow-up. Among a total 73 929 struts in every frame, 431 (26 stents) showed malapposition PCI. these, 49 remained malapposed follow-up...
Adverse plaque characteristics (APCs) by coronary computed tomography (CT) angiography (CTA) are associated with myocardial ischaemia and future acute syndromes. The overall objective was to determine whether APCs on non-invasive CTA vulnerable features invasive optical coherence (OCT). Sixty-eight plaques in 45 patients were evaluated OCT. were: positive remodelling (PR), index ≥1.10; low attenuation (LAP), any intraplaque voxel <30 Hounsfield units; spotty calcification (SC), ≤3 mm;...
Receptor for advanced glycation end products (RAGE) plays a pivotal role in the genesis of diabetic vascular diseases. To further explore mechanisms underlying atherosclerosis under non-diabetic conditions, we examined effect RAGE deficiency on hyperlipidaemic mice. RAGE−/− mice were crossed with low-density lipoprotein receptor-deficient (LDLr−/−) to generate double knockout (DKO) After feeding high-fat diet 12 weeks, aortic atherosclerotic lesions analysed histologically these Although...
<h3>Objective</h3> The aim of this study was to evaluate detailed vessel response after everolimus-eluting stents (EES) implantation in human de novo coronary lesions by optical coherence tomography (OCT). <h3>Design, setting and patients</h3> Between November 2008 October 2009, 25 patients (14 men, 65.5±8.6 years) with native artery were implanted 30 EES, OCT performed at 8 months post-implantation. <h3>Main outcome measures</h3> Neointimal thickness (NIT) on each strut, strut apposition...
AimsIn addition to their cholesterol-lowering effect, statins increase high-density lipoprotein cholesterol (HDL-C) levels. Endothelial lipase (EL) is a regulator of plasma HDL-C In the present study, effects on EL expression were investigated.
Cardiac resynchronization therapy (CRT) improves the clinical status of patients with congestive heart failure, although left ventricular epicardial pacing may increase transmural dispersion repolarization (TDR). The aim this study was to investigate time-dependent effect CRT on and arrhythmia at mid-term follow-up. group consisted 84 treated CRT. Twelve-lead electrocardiogram digitally recorded Tpeak-to-Tend interval (Tp–e) measured baseline, 1 week, month, 3, 6, 12 months after device...
It remains difficult to detect subtle left ventricular (LV) myocardial dysfunction in chronic aortic regurgitation (AR) patients with the preserved ejection fraction (EF). We studied 36 severe AR undergoing surgical correction EF of 58 ± 6% (all ≥50%). Echocardiography was performed before and 12 8 months after correction. used two-dimensional speckle-tracking strain imaging evaluate global radial inner-half (GRSinner), outer-half (GRSouter), total (GRStotal) layer from mid-LV short-axis...
Study objective – The aim was to clarify the effects of endothelin on coronary vasculature in intact rabbit by angiographic examination. Design By selective angiography bolus injections various amounts (0.01-1 nmol) were given into right artery anaesthetised rabbits. preventive nifedipine induced myocardial ischaemia examined. Subjects Adult male Japanese white rabbits (2.7-3.5 kg, n=29) used for vivo and vitro studies. Measurements main results Intracoronary administration 0.1 nmol led...
The aim of this study was to test the hypothesis that, unlike calculation mitral valve area (MVA) with pressure half-time method (PHT), proximal isovelocity surface (PISA) is not affected by changes in net atrioventricular compliance (C(n)).We studied 51 patients stenosis (MS) from two centres. MVA assessed PISA (MVA(PISA)), PHT (MVA(PHT)), and planimetry (MVA(PLN), serving as gold standard) method. C(n) calculated a previously validated equation using 2D echocardiography. MVA(PISA) closely...
Cardiac resynchronization therapy (CRT) can stop the vicious cycle resulting from dyssynchrony and generates left ventricular (LV) reverse remodelling. Our objective was to assess time course relationship between improvement in LV remodelling after CRT.Sixty-four consecutive patients were evaluated before, immediately after, 3- 6 months CRT. We measured volumes, ejection fraction (EF), sphericity index, assessed using speckle-tracking radial strain. Response defined as a >15% decrease...
Journal Article Palmitoyl-L-carnitine modifies the function of vascular endothelium Get access Nobutaka Inoue, Inoue First Department Internal Medicine, Kobe University School 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Japan: N K Hirata, H Akita, M Yokoyama. Correspondence to Dr Inoue. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ken-ichi Hirata Hozuka Akita Mitsuhiro Yokoyama Cardiovascular Research, Volume 28, Issue 1, January 1994, Pages 129–134,...
Fabry disease (FD) is a rare disorder and one of the causes progressive renal cardiac dysfunction. FD results from an X-linked recessive lysosomal storage caused by defect in gene encoding α-galactosidase A. Although accumulation globotriaosylceramide leads to manifestations, precise mechanisms remain unclear. Coronary microvascular dysfunction may be complications FD. We aimed assess coronary flow reserve (CFR) effect enzyme replacement therapy (ERT) on dysfunction.Four patients who had...
An 84-year-old man with non-ischaemic cardiomyopathy underwent cardiac resynchronization therapy (CRT) based on the presence of drug-refractory heart failure, depressed left ventricular ejection fraction (25%), and wide QRS complex (160 ms). Longitudinal tissue velocity revealed no significant dyssynchrony (23 ms in Yu index 35 opposing wall delay). However, longitudinal Doppler strain unique appearances apical four-chamber long-axis views. The anterior inferior septum at basal mid-levels...
Abstract Background Transthyretin amyloid cardiomyopathy (ATTR-CM) is characterized by the functional and structural consequences of infiltration predominantly within ventricles, causing biventricular wall thickening. Amyloid can be observed in left atrium ATTR-CM, however, association atrial (LA) myocardial function with cardiovascular events changes LA tafamidis administration have not been elucidated. Purpose The aim this study was to identify between baseline reservoir evaluated strain...
A 74-year-old asymptomatic female was referred to our hospital for examination of systolic ejection murmur. Transthoracic echocardiography showed mild aortic stenosis with a mean pressure gradient 18 mmHg and an valve area 1.50 cm2 determined by continuity equation. Two-dimensional real-time three-dimensional transoesophageal clearly bicuspid calcification the leaflet at 6 o'clock position ( Figure 1A B ). The computed tomography scan …