A5001869606- Medical Imaging Techniques and Applications
- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Frailty in Older Adults
- Dementia and Cognitive Impairment Research
- Nutrition and Health in Aging
- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Atomic and Subatomic Physics Research
- Older Adults Driving Studies
- Optical Imaging and Spectroscopy Techniques
- Advanced MRI Techniques and Applications
- Physical Activity and Health
- Radiopharmaceutical Chemistry and Applications
- Non-Invasive Vital Sign Monitoring
- MRI in cancer diagnosis
- Health disparities and outcomes
- Neuroscience and Neuropharmacology Research
- Cardiac Imaging and Diagnostics
- Musculoskeletal pain and rehabilitation
- Body Composition Measurement Techniques
Tokyo Metropolitan University
2023-2025
Osaka Metropolitan University
2023-2025
Kobe University
2024
National Center for Geriatrics and Gerontology
2012-2023
Toyama Prefectural University
2017-2022
National Cerebral and Cardiovascular Center
2009-2022
Nagoya University
1991-2021
Kyoto University
2007-2021
University of Tsukuba
2018
Kansai University
2018
A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate Report1 from Committee Principal Investigators SUMMARY double-blind intervention was started 1965 to test hypothesis that incidence middle-aged men can be reduced by lowering raised serum cholesterol levels.It carried out 3 European centres-Edinburgh, Budapest, and Prague.Serum lowered drug (ethyl chlorophenoxyisobutyrate) which considered free serious side effects.Studies were on 15 745 males, aged 30...
To examine the effects of a multicomponent exercise program on cognitive function older adults with amnestic mild impairment (aMCI). Design: Twelve months, randomized controlled trial; Setting: Community center in Japan; Participants: Fifty (27 men) aMCI ranging age from 65 to 93 years (mean age, 75 years); Intervention: Subjects were into either (n = 25) or an education control group 25). exercised under supervision physiotherapists for 90 min/d, 2 d/wk, total 80 times over 12 months. The...
To investigate changes in cerebral circulation and oxygen metabolism during aging, regional blood flow (rCBF), extraction fraction (rOEF), metabolic rate of (rCMRO2) volume (rCBV) were measured using the 15O labelled gas inhalation technique a multi-slice positron emission tomograph (PET) 22 healthy volunteers, aged from 26 to 64 years old. The measurements performed with subjects at rest, without sensory deprivation. values rCBF, rOEF, rCMRO2 rCBV more than 40 anatomical structures brain...
This study sought to confirm the test-retest reliability and validity of National Center for Geriatrics Gerontology functional assessment tool (NCGG-FAT), a newly developed multidimensional neurocognitive function using tablet personal computer (PC).This included 20 community-dwelling older adults (9 females, aged 65-81 years). Participants were administered NCGG-FAT twice, separated by approximately 30 days determine reliability. To test measure, participants underwent established...
A system for CBF measurement using an H 2 15 O autoradiographic method and positron emission tomography (PET) has been designed installed as a clinical tool. Following intravenous injection of O, radioactivity accumulation in the brain tissue 60 s continuous record arterial blood were measured by high counting speed PET device beta-ray detector, respectively, was calculated table-lookup procedure. First, this compared with C inhalation steady-state on 17 cerebrovascular disease patients four...
Objective: The clinical relationship between brain-derived neurotrophic factor (BDNF) and cognitive function or mild impairment (MCI) is not well understood. purpose of this study was to identify the serum BDNF MCI, determine whether level might be a useful biomarker for assessing risk MCI in older people.Materials Methods: A total 4463 individuals aged 65 years (mean age 72 years) participating study. We measured performance battery neuropsychological tests; concentration.Results: Eight...
Aim Several operative definitions and screening methods for sarcopenia have been proposed in previous studies; however, the opinions of researchers still differ. We compared prevalence using two different algorithms: (i) E uropean working group on older people ( EWGSOP )‐suggested algorithm gait speed as first step; (ii) muscle mass strength algorithm. Methods A population‐based, cross‐sectional survey adults aged over 65 years was carried out. Data a total 4811 participants were available...
Greater physical activity (PA) is associated with better memory performance and greater hippocampal volume in older adults. However, most studies to date assessed PA via questionnaires thereby lacked objective characterization of (eg, intensity, duration, etc.). Thus, we currently do not have a comprehensive understanding characteristics that are important for neuroprotection, especially among adults mild cognitive impairment (MCI). using triaxial accelerometers, examined the association...
Gait ability and cognitive function are interrelated during both normal walking (NW) dual-task (DTW), gait is thus adversely affected by impairment in situations. However, this association insufficiently understood people with mild (MCI). Here, we conducted a study MCI participants, to examine whether the depends on conditions subtypes. We classified 389 elderly adults into amnestic (n = 191) non-amnestic 198), assessed their functions, administered experiments under NW DTW conditions. was...
Abstract Background The aim of this study was to describe the age‐dependent changes in parameters physical performance and body composition Japanese older adults who are independently dwelling community. We also examined whether differ among parameters. Methods Cross‐sectional data from 10 092 community‐dwelling (mean age 73.6 years; 5296 women) were analyzed. measures included hand‐grip strength, five‐times‐sit‐to‐stand test, walking speed. Body (body weight, fat mass, appendicular skeletal...
Aim Cognitive impairment can negatively affect driving performance and increase the risk of errors, leading to vehicle crashes. We used a population‐based survey identify prevalence cognitive impairments in older drivers. Methods A total 10 073 adults were enrolled N ational C enter for G eriatrics erontology – S tudy eriatric yndromes. characterized general using Mini‐Mental State Examination ( MMSE ). also erontology‐ F unctional ssessment T ool, which includes six tasks assess word list...
Bioelectrical impedance analysis (BIA)-derived phase angle is expected to be an efficient prognostic marker of health adverse events with aging as alternative muscle mass. We aimed examine the predictive ability for incident disability in community-dwelling elderly and determine optimal cut-off values.Community-dwelling aged ≥65 years (n = 4452; mean age 71.8 ± 5.3 years, 48.3% women) without at baseline participated this prospective cohort study. Phase appendicular skeletal mass (ASM) were...
We studied 15 patients clinically suspected to have recurrent brain tumor or radiation injury, using positron emission tomography (PET) with 18F-fluorodeoxyglucose (18FDG) and L-methyl-11C-methionine (11C-Met). PET 11C-Met (Met-PET) clearly delineated the extent of as focal areas increased accumulation 11C-Met, was useful for early detection tumor. 18FDG (FDG-PET) showed 18FDG-hypermetabolism in one patient malignant transformation low grade glioma, demonstrated its usefulness evaluation...
The tracer appearance time relative to the radial artery–sampling site has been evaluated in six brain locations five human subjects using dynamic positron emission tomography (PET) following bolus injection of H 2 15 O. There was a maximum difference ± s from average each location. T o globally adjust timing between measured arterial curve and PET scan, correction method developed based on nonlinear least-squares fitting procedure. This new technique determined global delay with an accuracy...
Recently, several studies have reported age-associated increases in muscle coactivation during postural control. A rigid posture induced by strong reduces the degree of freedom to be organized control system. The purpose this study was clarify effect balance training on older adults. Forty-eight subjects were randomized into an intervention (mean age: 81.0 ± 6.9 years) and a group 81.6 6.4 years). did not receive any intervention. Postural ability (postural sway quiet standing, functional...
To identify appropriate clinical tests for determining the demand personal care in older Japanese people.Cross-sectional observation study.Obu Study of Health Promotion Elderly (Obu, Aichi) and Tsukui Ordered Useful Care (241 day-care centres) cohorts Japan.A total 10 351 individuals aged 65 years or (6791 with 3560 without care) participated study.Physical performance included grip strength, chair stand test, walking speed at a comfortable pace, timed up-and-go test. Personal was defined as...
Aim To examine the association of combination slow gait and mild cognitive impairment ( MCI ) with function falling in community‐dwelling older people. Methods Participants were selected from O bu S tudy H ealth P romotion for E lderly n = 3400), underwent examination a battery neuropsychological examinations, including M ini‐ ental tate xamination N ational C enter G eriatrics erontology F unctional A ssessment T ool (tablet version rail aking est art B , ymbol D igit ubstitution ask,...