A5101985298- Developmental Biology and Gene Regulation
- Balance, Gait, and Falls Prevention
- Genetics, Aging, and Longevity in Model Organisms
- Muscle Physiology and Disorders
- Cellular transport and secretion
- PI3K/AKT/mTOR signaling in cancer
- dental development and anomalies
- Marine and Coastal Research
- RNA Research and Splicing
- Congenital heart defects research
- Bone and Dental Protein Studies
- Structural Integrity and Reliability Analysis
- Cerebral Palsy and Movement Disorders
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Calcium signaling and nucleotide metabolism
- Motor Control and Adaptation
- Fish biology, ecology, and behavior
- Peripheral Nerve Disorders
- FOXO transcription factor regulation
- Circadian rhythm and melatonin
- Biomedical Research and Pathophysiology
- Polyamine Metabolism and Applications
- Veterinary Orthopedics and Neurology
- Musculoskeletal pain and rehabilitation
Kwansei Gakuin University
2020-2024
Rutgers, The State University of New Jersey
2020-2022
Kyoto University
2011-2019
Nagoya University
2011-2019
Yokohama National University
2011-2016
Osaka University
2011-2014
Shibuya (Japan)
2013
Ehime University
2001
The mechanistic target of rapamycin (mTOR) functions as a component two large complexes, mTORC1 and mTORC2, which play crucial roles in regulating cell growth homeostasis. However, the molecular mechanisms by mTOR controls proliferation remain elusive. Here we show that FoxO3a transcription factor is coordinately regulated plays role controlling proliferation. To dissect signaling, was specifically inactivated depleting p18, an essential anchor on lysosomes. inactivation caused marked...
Recently, several studies have reported age-associated increases in muscle coactivation during postural control. A rigid posture induced by strong reduces the degree of freedom to be organized control system. The purpose this study was clarify effect balance training on older adults. Forty-eight subjects were randomized into an intervention (mean age: 81.0 ± 6.9 years) and a group 81.6 6.4 years). did not receive any intervention. Postural ability (postural sway quiet standing, functional...
The lysosomal adaptor protein p18 is an essential anchor of a scaffolding complex for the mTORC1 and MAPK pathways, which play crucial roles in controlling cell growth energy homeostasis. To elucidate vivo function p18-mediated pathway, we conditionally ablated mouse epidermis. Mutant mice were born with severe defects formation stratum corneum died within 12 h after birth due to dehydration caused by loss skin barrier function. epidermal cells can grow differentiate into granular cells, but...
Abstract Limb development starts with the formation of limb buds (LBs), which consist tissues from two different germ layers; lateral plate mesoderm-derived mesenchyme and ectoderm-derived surface epithelium. Here, we report means for induction an LB-like mesenchymal/epithelial complex murine pluripotent stem cells (PSCs) in vitro. The selectively differentiate into forelimb- or hindlimb-type mesenchymes, depending on a concentration retinoic acid. Comparative transcriptome analysis reveals...
In eukaryotes and archaea, tRNA genes frequently contain introns, which are removed during maturation. However, biological roles of introns remain elusive. Here, we constructed a complete set Saccharomyces cerevisiae strains in the were from all synonymous encoding 10 different species. All intronless viable, but tRNAPheGAA tRNATyrGUA displayed slow growth, cold sensitivity defective growth under respiratory conditions, indicating physiological importance certain introns. Northern analyses...
Abstract Odontodes, i.e., teeth and tooth-like structures, consist of a pulp cavity dentin covered by mineralized cap. These structures first appeared on the outer surface vertebrate ancestors were repeatedly lost gained across clades; yet, underlying genetic mechanisms trajectories this recurrent evolution remain long-standing mysteries. Here, we established suckermouth armored catfish ( Ancistrus sp. ; Loricariidae), which have reacquired dermal odontodes (dermal denticles) all over most...
Tropomyosin (TM) is a regulatory protein of actomyosin system. Muscle type-specific expression TM isoforms generated from different genes and by alternative splicing. β-TM in chicken skeletal smooth muscles are encoded single gene transcribed the same promoter. We previously reported muscle cell (SMC) phenotype-dependent change (Kashiwada, K., Nishida, W., Hayashi, Ozawa, Yamanaka, Y., Saga, H., Yamashita, T., Tohyama, M., Shimada, S., Sato, Sobue, K. (1997) J. Biol. Chem. 272, 15396–15404),...
A part of eukaryotic tRNA genes harbor an intron at one nucleotide 3′ to the anticodon, so that removal is essential processing step for maturation. While some introns have important roles in modification certain nucleotides, essentiality eukaryotes has not been tested extensively. This partly because most genomes multiple encoding isoacceptor tRNA. Here, we examined whether tRNA-Trp CCA genes, six copies which are scattered on genome yeast, Saccharomyces cerevisiae , growth or translation...
During development of the Caenorhabditis elegans gonad, gonadal leader cells, called distal tip cells (DTCs), migrate in a U-shaped pattern to form gonad arms. The ADAMTS ( d isintegrin nd m etalloprotease with t hrombo s pondin motifs) family metalloproteases MIG-17 and GON-1 are required for correct DTC migration. Mutations mig-17 result misshapen gonads due misdirected migration, mutations gon-1 shortened swollen premature termination Although phenotypes shown by mutants very different...
ABSTRACT Odontodes, i.e., teeth and tooth-like structures, consist of a pulp cavity dentine covered by mineralized cap. These structures first appeared on the outer surface vertebrate ancestors were repeatedly lost gained across clades; yet, underlying genetic mechanisms trajectories this recurrent evolution remain long-standing mysteries. Here, we established suckermouth armored catfish ( Ancistrus sp. ; Loricariidae), which have uniquely evolved dermal odontodes (dermal denticles) all over...
In the safety management in bottom plate of an oil storage tank, it is important to detect local corrosion accurately because its critical phenomenon for preventing a serious accident. Although discrete measurement based on Fire Services Act carried out, maximum depth would not be detected. Therefore, this study out estimate by using thickness previous inspection data and Bayesian statistics. As result, estimated with proposed method was good agreement actual depth.
Abstract During development of the Caenorhabditis elegans gonad, gonadal leader cells, called distal tip cells (DTCs), migrate in a U-shaped pattern to form gonad arms. The ADAMTS ( d isintegrin nd m etalloprotease with t hrombo s pondin motifs) family metalloproteases MIG-17 and GON-1 are required for correct DTC migration. Mutations mig-17 result misshapen gonads due misdirected migration, mutations gon-1 shortened swollen premature termination Although phenotypes shown by mutants very...