A5075495901- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Cancer, Lipids, and Metabolism
- Cardiac electrophysiology and arrhythmias
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Cardiac Valve Diseases and Treatments
- Cardiac Ischemia and Reperfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Fatty Acid Research and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Hormonal and reproductive studies
- Diet, Metabolism, and Disease
- Atrial Fibrillation Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrest and Resuscitation
- Analytical Methods in Pharmaceuticals
- Thyroid Disorders and Treatments
- Antioxidant Activity and Oxidative Stress
University of Missouri
2024
University of Edinburgh
1961-2011
Cosmetics Europe
2006
Canary Wharf Group (United Kingdom)
2001
Lung Institute
1999
University of Leicester
1999
Glenfield Hospital
1999
University of Aberdeen
1991
Hutt Hospital
1982
MRC Centre for Regenerative Medicine
1982
A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate Report1 from Committee Principal Investigators SUMMARY double-blind intervention was started 1965 to test hypothesis that incidence middle-aged men can be reduced by lowering raised serum cholesterol levels.It carried out 3 European centres-Edinburgh, Budapest, and Prague.Serum lowered drug (ethyl chlorophenoxyisobutyrate) which considered free serious side effects.Studies were on 15 745 males, aged 30...
SUMMARY 1. Certain analogues of thyroxine have been administered to twenty-six hypothyroid patients and 132 euthyroid hypercholesterolaemic men with coronary heart disease. The studied were d -thyroxine, 3:5:3′:5′-tetraiodothyroformic acid, 3:5:3′:5′-tetraiodothyronamine, 3:5:3′-triiodo- l -thyronine, 3:5:3′-triiodothyroacetic 3:5-diiodo- -thyronine 3:5-diiodothyroacetic acid. 2. In both patients, most these reduced the serum cholesterol without necessarily elevating basal metabolic rate (...
Evidence that an excess of plasma free fatty acids (FFA) might lead to primary ventricular fibrillation and sudden cardiac death has hardened over the 36 years since hypothesis was proposed. When sympathetic nervous system is stimulated during onset acute coronary syndrome, catecholamine-induced tissue lipolysis occurs, with a surge FFA. This may overload acutely ischaemic myocardium impair glucose utilization. Myocardial oxygen consumption can increase in regional areas ischaemia, could...
Studies were made in the anaesthetised dog of effects repeated acute occlusions a branch anterior descending coronary artery on ventricular refractory periods adjacent ischaemic and non-ischaemic myocardium. Differences occurred refractoriness between normal areas ventricle. This was greatest 2.5 min after occlusion, release reverted to within 5 min. Spontaneous fibrillation directly significantly related degree dispersion given immediately preceding following occlusion. Infusion...
Glucose metabolism in the healthy heart is stimulated by dichloroacetate (DCA). The possibility has been examined dogs that DCA, increasing glucose utilization, might limit severity of acute myocardial ischaemic injury. Intravenous administration DCA reduced degree epicardial ST-segment elevation induced subsequent coronary occlusion, both under basal conditions and during isoprenaline infusion. A similar result was obtained when given an established occlusion. This effect could not be...
The post-myocardial-infarction syndrome is character- ized by prolonged pericardial friction, persistent chest pain, continuing fever, and, in many instances, and pleural effusion.These features develop during the first few weeks after myocardial infarction.The whole illness may pursue a relapsing course for months.The was described Dressler (1956), 1959 he reported its occurrence 44 patients.He estimated that complicates from 3 to 4% of cases infarction, it therefore remarkable has escaped...
SUMMARY Normal skin of healthy individuals and both lesional uninvolved from patients with psoriasis before after receiving cyclosporin A (CsA; 25 or 5 mg/kg per day) was examined by immunocytochemistry for differences in expression adhesion-relevant epitopes. Normal, all showed staining basal keratinocytes CD29 (the common β chain the βl-integrin family). No other adhesion molecule investigated detected on structural components normal skin. In skin, weak CD54 (intercellular I, ICAM-1) noted...
Journal Article Evaluation of antiplatelet agents in the prevention aorto-coronary bypass occlusion Get access M. VERSTRAETE, VERSTRAETE Prof. Verstraete, Centre for Thrombosis and Vascular Research, University Leuven, Campus Gasthuisberg, Herestraat 49, B-3000 Belgium Search other works by this author on: Oxford Academic PubMed Google Scholar B. G. BROWN, BROWN J. H. CHESEBRO, CHESEBRO S. EKESTRÖM, EKESTRÖM L. A. HARKER, HARKER HENDERSON, HENDERSON D. E. JEWITT, JEWITT F. OLIVER, OLIVER P....
Abnormally high circulating free fatty acid (FFA) levels occur in the early hours of acute myocardial infarction man.Experimentally, reduction plasma FFA has been shown to reduce ischaemic injury.The effect lowering by antilipolytic therapy using a nico- tinic analogue (NAA) studied man within 6 onset symptoms myo- cardial infarction.Myocardial injury was assessed continuous recording and computer analysis ST segment elevations 15 treated untreated patients.High dose NAA treatment 9 patients...
Free fatty acid concentrations in plasma measured after vivo heparinisation are often overestimated because of ex lipolysis variable degrees. A new method has been developed using immediate extraction blood which obviates this and shows that the true rise free concentration heparin ambulant ward patients with acute myocardial infarction is less than previously reported. The small unlikely to have adverse metabolic effects most during infarction.
but it would be interesting to know what brand was used in the study by S.